PLSCR3
Phospholipid scramblase 3
Protein Summary
May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system. Seems to play a role in apoptosis, through translocation of cardiolipin from the inner to the outer mitochondrial membrane which promotes BID recruitment and enhances tBid-induced mitochondrial damages.
- ENST00000324822
- ENSP00000316021
- ENSG00000187838
- ENST00000535512
- ENSP00000438547
- ENST00000574401
- ENSP00000459019
- ENST00000576201
- ENSP00000459419
- ENST00000639780
- ENSP00000492083
- ENSG00000284009
- ENST00000640053
- ENSP00000491350
- ENST00000640375
- ENSP00000491393
- ENST00000640848
- ENSP00000492348
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
metabolite | 0.98 | ||
kinase perturbation | 0.91 | ||
transcription factor perturbation | 0.88 | ||
tissue sample | 0.73 | ||
transcription factor | 0.66 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 14.04 (req: < 5)
Gene RIFs: 9 (req: <= 3)
Antibodies: 149 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 14.04 (req: >= 5)
Gene RIFs: 9 (req: > 3)
Antibodies: 149 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 9
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0