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Tbio
PLSCR3
Phospholipid scramblase 3

Protein Summary
Description
May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system. Seems to play a role in apoptosis, through translocation of cardiolipin from the inner to the outer mitochondrial membrane which promotes BID recruitment and enhances tBid-induced mitochondrial damages.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000324822
  • ENSP00000316021
  • ENSG00000187838
  • ENST00000535512
  • ENSP00000438547
  • ENST00000574401
  • ENSP00000459019
  • ENST00000576201
  • ENSP00000459419
  • ENST00000639780
  • ENSP00000492083
  • ENSG00000284009
  • ENST00000640053
  • ENSP00000491350
  • ENST00000640375
  • ENSP00000491393
  • ENST00000640848
  • ENSP00000492348
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
metabolite
0.98
kinase perturbation
0.91
transcription factor perturbation
0.88
tissue sample
0.73
transcription factor
0.66


Related Tools
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.24   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 149   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.24   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 149   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
phospholipid scramblase 3
VGNC:51726
750610
Macaque
phospholipid scramblase 3
721831
Mouse
MGI:1917560
70310
Rat
RGD:1307016
360549
Dog
phospholipid scramblase 3
489471
Species
Name
OMA
EggNOG
Inparanoid
Chimp
phospholipid scramblase 3
Macaque
phospholipid scramblase 3
Mouse
Rat
Dog
phospholipid scramblase 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9NRY6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Protein-Protein Interactions (33)
1 – 10 of 33
PRKCD
Tclin
Family: Kinase
Novelty: 0.0009758
Score: 0.674
Data Source: STRINGDB
PLS3
Tbio
Novelty: 0.00650492
Score: 0.654
Data Source: STRINGDB
PDCD6
Tbio
Novelty: 0.0139857
Score: 0.637
Data Source: STRINGDB
ATP8A2
Tbio
Family: Transporter
Novelty: 0.03876526
Score: 0.623
Data Source: STRINGDB
MUC4
Tbio
Novelty: 0.00193208
Score: 0.622
Data Source: STRINGDB
ANO6
Tbio
Family: IC
Novelty: 0.01288434
Score: 0.617
Data Source: STRINGDB
CHERP
Tbio
Novelty: 0.06955626
Score: 0.559
Data Source: STRINGDB
XKR8
Tbio
Novelty: 0.08472323
Score: 0.556
Data Source: STRINGDB
SHISA4
Tdark
Novelty: 1.61444286
Score: 0.555
Data Source: STRINGDB
SHISA5
Tbio
Novelty: 0.18952761
Score: 0.515
Data Source: STRINGDB
Publication Statistics
PubMed Score  13.24

PubMed score by year
PubTator Score  13.82

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer