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Tdark
FAM114A2
Protein FAM114A2

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000351797
  • ENSP00000341597
  • ENSG00000055147
  • ENST00000520667
  • ENSP00000430384
  • ENST00000522858
  • ENSP00000430489

Symbol
  • C5orf3
  • 133K02
  • C5orf3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.96
histone modification site profile
0.85
transcription factor binding site profile
0.78
kinase perturbation
0.76
tissue
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.61   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 59   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.61   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 59   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (104)
1 – 10 of 104
KIR2DL1
Tbio
Novelty:  0.00523657
p_int:  0.999999972
p_ni:  2.8e-8
Data Source:  BioPlex
KIR3DL2
Tbio
Novelty:  0.00321353
p_int:  0.99999216
p_ni:  0.00000784
Score:  0.181
Data Source:  BioPlex,STRINGDB
TMEM51
Tdark
Novelty:  0.54147214
p_int:  0.999987788
p_ni:  0.000012212
Score:  0.175
Data Source:  BioPlex,STRINGDB
EPHA1
Tchem
Family:  Kinase
Novelty:  0.00136672
p_int:  0.999981741
p_ni:  0.00001824
p_wrong:  1.9e-8
Data Source:  BioPlex
IFT20
Tbio
Novelty:  0.03005088
p_int:  0.999757769
p_ni:  0.000242206
p_wrong:  2.6e-8
Data Source:  BioPlex
CLEC2B
Tbio
Novelty:  0.06581244
p_int:  0.999714735
p_ni:  0.000284695
p_wrong:  5.69e-7
Data Source:  BioPlex
LRRC4
Tbio
Novelty:  0.03600857
p_int:  0.999065625
p_ni:  0.000928367
p_wrong:  0.000006008
Score:  0.189
Data Source:  BioPlex,STRINGDB
SCN2B
Tbio
Family:  IC
Novelty:  0.03773629
p_int:  0.998969095
p_ni:  0.001030834
p_wrong:  7.1e-8
Data Source:  BioPlex
PIK3IP1
Tbio
Family:  Enzyme
Novelty:  0.07364653
p_int:  0.997912969
p_ni:  0.002080088
p_wrong:  0.000006944
Data Source:  BioPlex
GPSM3
Tbio
Novelty:  0.01632501
p_int:  0.997424875
p_ni:  0.002450575
p_wrong:  0.00012455
Data Source:  BioPlex
Pathways (4)
Disease (R-HSA-1643685)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Disease
Reactome
Diseases of signal transduction
Reactome
Oncogenic MAPK signaling
Reactome
Signaling by BRAF and RAF fusions
Name
Explore in Pharos
Explore in Source
Disease
Diseases of signal transduction
Oncogenic MAPK signaling
Signaling by BRAF and RAF fusions
Gene Ontology Terms (1)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Non-traceable Author Statement (NAS)
UniProtKB
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
3
2
3
88
body mass index
2
1
2
54.4
smoking status measurement
1
1
1
27.3
mathematical ability
1
1
1
21.5
self reported educational attainment
1
1
1
17.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
3
88
body mass index
2
54.4
smoking status measurement
1
27.3
mathematical ability
1
21.5
self reported educational attainment
1
17.8
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
family with sequence similarity 114 member A2
VGNC:3983
462204
Macaque
family with sequence similarity 114 member A2
713205
Mouse
MGI:1917629
67726
Rat
Dog
family with sequence similarity 114 member A2
VGNC:40581
489167
Species
Name
OMA
EggNOG
Inparanoid
Chimp
family with sequence similarity 114 member A2
Macaque
family with sequence similarity 114 member A2
Mouse
Rat
Dog
family with sequence similarity 114 member A2
Publication Statistics
PubMed Score 3.61
PubMed score by year
PubTator Score 1.00
PubTator score by year