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Tbio
ARHGAP35
Rho GTPase-activating protein 35

Protein Summary
Description
Rho GTPase-activating protein (GAP) (PubMed:19673492, PubMed:28894085). Binds several acidic phospholipids which inhibits the Rho GAP activity to promote the Rac GAP activity (PubMed:19673492). This binding is inhibited by phosphorylation by PRKCA (PubMed:19673492). Involved in cell differentiation as well as cell adhesion and migration, plays an important role in retinal tissue morphogenesis, neural tube fusion, midline fusion of the cerebral hemispheres and mammary gland branching morphogenesis (By similarity). Transduces signals from p21-ras to the nucleus, acting via the ras GTPase-activating protein (GAP) (By similarity). Transduces SRC-dependent signals from cell-surface adhesion molecules, such as laminin, to promote neurite outgrowth. Regulates axon outgrowth, guidance and fasciculation (By similarity). Modulates Rho GTPase-dependent F-actin polymerization, organization and assembly, is involved in polarized cell migration and in the positive regulation of ciliogenesis and cili ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000404338
  • ENSP00000385720
  • ENSG00000160007
  • ENST00000614079
  • ENSP00000483730

Symbol
  • GRF1
  • GRLF1
  • KIAA1722
  • P190A
  • p190ARHOGAP
  • GRF-1
  • GRLF1
  • P190A
  • P190-A
  • p190RhoGAP
  • p190ARhoGAP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
biological process
0.9
transcription factor perturbation
0.88
kinase
0.8
interacting protein
0.77


Related Tools
GENEVA
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 90.51   (req: < 5)
Gene RIFs: 30   (req: <= 3)
Antibodies: 243   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 90.51   (req: >= 5)
Gene RIFs: 30   (req: > 3)
Antibodies: 243   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 33
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Rho GTPase activating protein 35
VGNC:2106
456157
Macaque
Rho GTPase activating protein 35
716936
Mouse
MGI:1929494
232906
Rat
RGD:1308738
306400
Dog
Rho GTPase activating protein 35
VGNC:38060
403543
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Rho GTPase activating protein 35
Macaque
Rho GTPase activating protein 35
Mouse
Rat
Dog
Rho GTPase activating protein 35
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9NRY4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (24)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
Reactome
Rho GTPase cycle
Reactome
Sema4D in semaphorin signaling
Name
Explore in Pharos
Explore in Source
Axon guidance
Developmental Biology
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
Rho GTPase cycle
Sema4D in semaphorin signaling
Gene Ontology Terms (38)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (110)
1 – 10 of 110
SERPINB2
Tbio
Novelty: 0.00204345
p_int: 0.996436519
p_ni: 6.84e-7
p_wrong: 0.003562797
Score: 0.224
Data Source: BioPlex,STRINGDB
RHOA
Tbio
Family: Enzyme
Novelty: 0.00022204
Score: 0.998
Data Source: Reactome,STRINGDB
RHOC
Tbio
Family: Enzyme
Novelty: 0.00262213
Score: 0.993
Data Source: STRINGDB
SRC
Tclin
Family: Kinase
Novelty: 0.00008479
Score: 0.99
Data Source: STRINGDB
RASA1
Tbio
Family: Enzyme
Novelty: 0.00425286
Score: 0.989
Data Source: Reactome,STRINGDB
CDC42
Tchem
Family: Enzyme
Novelty: 0.00032619
Score: 0.988
Data Source: STRINGDB
RHOB
Tbio
Family: Enzyme
Novelty: 0.0019205
Score: 0.987
Data Source: STRINGDB
RND1
Tbio
Family: Enzyme
Novelty: 0.00834946
Score: 0.981
Data Source: Reactome,STRINGDB
RAC1
Tbio
Family: Enzyme
Novelty: 0.00365325
Score: 0.98
Data Source: STRINGDB
FYN
Tclin
Family: Kinase
Novelty: 0.00072167
Score: 0.976
Data Source: STRINGDB
Publication Statistics
PubMed Score  90.51

PubMed score by year
PubTator Score  74.12

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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