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Tclin
NDUFA4L2
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2

Protein Classes
Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000393825
  • ENSP00000377411
  • ENSG00000185633
  • ENST00000554503
  • ENSP00000450664

Symbol
  • NUOMS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.68
PubMedID
0.65
histone modification site profile
0.63
transcription factor binding site profile
0.62
tissue sample
0.61


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.27   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 103   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.27   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 103   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
metformin
Rendered image for metformin
GWAS Traits (26)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
2
5
5
96.3
apolipoprotein A 1 measurement
1
3
3
90.2
high density lipoprotein cholesterol measurement
1
3
3
88.6
triglyceride measurement
2
2
2
85.2
sex hormone-binding globulin measurement
2
1
2
79.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
5
96.3
apolipoprotein A 1 measurement
3
90.2
high density lipoprotein cholesterol measurement
3
88.6
triglyceride measurement
2
85.2
sex hormone-binding globulin measurement
2
79.4
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
NDUFA4, mitochondrial complex associated like 2
714483
Mouse
MGI:3039567
407790
Rat
RGD:2324558
100362331
Dog
NDUFA4, mitochondrial complex associated like 2
VGNC:43688
607407
Horse
NDUFA4, mitochondrial complex associated like 2
VGNC:20625
100052985
Species
Name
OMA
EggNOG
Inparanoid
Macaque
NDUFA4, mitochondrial complex associated like 2
Mouse
Rat
Dog
NDUFA4, mitochondrial complex associated like 2
Horse
NDUFA4, mitochondrial complex associated like 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9NRX3-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (30)
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Retrograde endocannabinoid signaling
KEGG
Non-alcoholic fatty liver disease (NAFLD)
KEGG
Alzheimer disease
KEGG
Huntington disease
KEGG
Thermogenesis
Name
Explore in Pharos
Explore in Source
Retrograde endocannabinoid signaling
Non-alcoholic fatty liver disease (NAFLD)
Alzheimer disease
Huntington disease
Thermogenesis
Gene Ontology Terms (3)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (64)
1 – 10 of 64
POTEI
Tdark
Novelty:  0.41311202
p_int:  0.999988978
p_ni:  0.00001102
p_wrong:  2e-9
Score:  0.189
Data Source:  BioPlex,STRINGDB
HSP90AA4P
Tdark
p_int:  0.985580358
p_ni:  0.0144196
p_wrong:  4.2e-8
Data Source:  BioPlex
ACTBL2
Tbio
Novelty:  0.18080702
p_int:  0.926046281
p_ni:  0.073953709
p_wrong:  9e-9
Data Source:  BioPlex
ACTC1
Tbio
Novelty:  0.00188036
p_int:  0.750102572
p_ni:  0.249897428
Score:  0.285
Data Source:  BioPlex,STRINGDB
NDUFA4
Tclin
Family:  Enzyme
Novelty:  0.03103013
Score:  0.805
Data Source:  STRINGDB
COX4I2
Tbio
Family:  Enzyme
Novelty:  0.00965049
Score:  0.803
Data Source:  STRINGDB
UQCR10
Tbio
Novelty:  0.04536078
Score:  0.796
Data Source:  STRINGDB
COX4I1
Tbio
Family:  Enzyme
Novelty:  0.00208873
Score:  0.719
Data Source:  STRINGDB
UQCRFS1
Tbio
Novelty:  0.00341256
Score:  0.71
Data Source:  STRINGDB
UQCRC1
Tbio
Family:  Enzyme
Novelty:  0.01746759
Score:  0.688
Data Source:  STRINGDB
Publication Statistics
PubMed Score  16.27

PubMed score by year
PubTator Score  7.51

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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