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Tdark
MRPL17
39S ribosomal protein L17, mitochondrial

Protein Summary
Description
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000288937
  • ENSP00000288937
  • ENSG00000158042

Symbol
  • LIP2
  • LIP2
  • L17mt
  • RPL17L
  • RPML26
  • MRP-L17
  • MRP-L26
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.97
kinase perturbation
0.84
transcription factor binding site profile
0.81
virus perturbation
0.76
cellular component
0.7


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.62   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 43   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.62   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 43   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
mitochondrial ribosomal protein L17
697086
Mouse
MGI:1351608
27397
Rat
RGD:70943
171061
Dog
mitochondrial ribosomal protein L17
VGNC:43381
610200
Horse
mitochondrial ribosomal protein L17
VGNC:20328
100055298
Species
Name
OMA
EggNOG
Inparanoid
Macaque
mitochondrial ribosomal protein L17
Mouse
Rat
Dog
mitochondrial ribosomal protein L17
Horse
mitochondrial ribosomal protein L17
Protein Structure (5 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9NRX2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (7)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Mitochondrial translation
Reactome
Mitochondrial translation elongation
Reactome
Mitochondrial translation initiation
Reactome
Mitochondrial translation termination
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Mitochondrial translation
Mitochondrial translation elongation
Mitochondrial translation initiation
Mitochondrial translation termination
Gene Ontology Terms (7)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (260)
1 – 10 of 260
MRPS30
Tbio
Novelty: 0.08115544
p_int: 0.99973737
p_ni: 0.00026263
Score: 0.996
Data Source: BioPlex,STRINGDB
MRPL18
Tbio
Novelty: 0.73438796
p_int: 0.99962725
p_ni: 0.00037275
Score: 0.998
Data Source: BioPlex,STRINGDB
MRPL13
Tbio
Novelty: 0.04173503
p_int: 0.999186559
p_ni: 0.000813441
Score: 0.999
Data Source: BioPlex,STRINGDB
MRPL50
Tdark
Novelty: 0.88879319
p_int: 0.998819742
p_ni: 0.001180258
Score: 0.994
Data Source: BioPlex,STRINGDB
MRPL10
Tbio
Novelty: 0.27087019
p_int: 0.998495169
p_ni: 0.001504831
Score: 0.989
Data Source: BioPlex,STRINGDB
MRPL47
Tbio
Novelty: 0.05648009
p_int: 0.996934157
p_ni: 0.003065843
Score: 0.999
Data Source: BioPlex,STRINGDB
MRPL4
Tdark
Novelty: 0.27290276
p_int: 0.995951334
p_ni: 0.004048666
Score: 0.999
Data Source: BioPlex,STRINGDB
MRPL30
Tdark
Novelty: 1.03623556
p_int: 0.989762791
p_ni: 0.010237209
Score: 0.984
Data Source: BioPlex,STRINGDB
MRPL53
Tdark
Novelty: 1.0076471
p_int: 0.986531499
p_ni: 0.013468501
Score: 0.986
Data Source: BioPlex,STRINGDB
MRPL39
Tbio
Novelty: 0.14346457
p_int: 0.984788967
p_ni: 0.015211033
Score: 0.988
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  0.62

PubMed score by year
PubTator Score  0.17

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer