Tbio PNO1 RNA-binding protein PNO1

Protein Summary

Description

Positively regulates dimethylation of two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA (PubMed:25851604).

Uniprot Accession IDs

• Q9NRX1
• A8K6Q0
• Q53G13
• Q8WVB8

Gene Name

• PNO1

Ensembl ID

• ENST00000263657
• ENSP00000263657
• ENSG00000115946

Symbol

• RRP20
• KHRBP1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.93
kinase perturbation	0.93
protein complex	0.92
histone modification site profile	0.9
transcription factor perturbation	0.88

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.03   (req: < 5)

Gene RIFs: 12   (req: <= 3)

Antibodies: 76   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.03   (req: >= 5)

Gene RIFs: 12   (req: > 3)

Antibodies: 76   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0