Tbio DUSP22 Dual specificity protein phosphatase 22

Protein Summary

Description

Activates the Jnk signaling pathway. Dephosphorylates and deactivates p38 and stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) (By similarity).

Uniprot Accession IDs

• Q9NRW4
• B4DK56
• Q59GW2
• Q5VWR2
• Q96AR1

Gene Name

• DUSP22

Ensembl ID

• ENST00000344450
• ENSP00000345281
• ENSG00000112679
• ENST00000419235
• ENSP00000397459

Symbol

• JSP1
• LMWDSP2
• MKPX
• VHX
• JKAP
• JSP1
• MKPX
• JSP-1
• MKP-x
• LMWDSP2
• LMW-DSP2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.91
biological process	0.87
protein domain	0.85
kinase perturbation	0.84
transcription factor	0.69

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 108.52   (req: < 5)

Gene RIFs: 35   (req: <= 3)

Antibodies: 290   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 108.52   (req: >= 5)

Gene RIFs: 35   (req: > 3)

Antibodies: 290   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0