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Tbio
APOBEC3C
DNA dC->dU-editing enzyme APOBEC-3C

Protein Summary
Description
DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single-or double-stranded RNA. Exhibits antiviral activity against simian immunodeficiency virus (SIV), hepatitis B virus (HBV), herpes simplex virus 1 (HHV-1) and Epstein-Barr virus (EBV) and may inhibit the mob ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361441
  • ENSP00000355340
  • ENSG00000244509

Symbol
  • APOBEC1L
  • PBI
  • A3C
  • PBI
  • ARP5
  • ARDC2
  • ARDC4
  • APOBEC1L
  • bK150C2.3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.75
histone modification site profile
0.69
biological process
0.68
cell type or tissue
0.67
tissue sample
0.67


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 107.77   (req: < 5)
Gene RIFs: 38   (req: <= 3)
Antibodies: 232   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 107.77   (req: >= 5)
Gene RIFs: 38   (req: > 3)
Antibodies: 232   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
1
1
1
76.1
red blood cell distribution width
2
2
3
61.4
2
1
0
1.2
10.1
platelet count
1
1
1
5
leukocyte count
1
1
1
4.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
1
76.1
red blood cell distribution width
3
61.4
0
1.2
10.1
platelet count
1
5
leukocyte count
1
4.1
Orthologs (1)
1 – 1 of 1
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
DNA dC->dU-editing enzyme APOBEC-3F [Source:RefSeq peptide;Acc:NP_001035832]
Species
Name
OMA
EggNOG
Inparanoid
Macaque
DNA dC->dU-editing enzyme APOBEC-3F [Source:RefSeq peptide;Acc:NP_001035832]
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9NRW3-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (5)
Formation of the Editosome (R-HSA-75094)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Formation of the Editosome
Reactome
Metabolism of RNA
Reactome
mRNA Editing
Reactome
mRNA Editing: C to U Conversion
Name
Explore in Pharos
Explore in Source
Formation of the Editosome
Metabolism of RNA
mRNA Editing
mRNA Editing: C to U Conversion
Gene Ontology Terms (16)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (54)
1 – 10 of 54
RRS1
Tbio
Novelty:  0.01643671
p_int:  0.998026323
p_ni:  0.001156628
p_wrong:  0.000817049
Data Source:  BioPlex
XPC
Tbio
Novelty:  0.00775175
p_int:  0.997748253
p_ni:  0.000625313
p_wrong:  0.001626434
Data Source:  BioPlex
ZBTB48
Tbio
Family:  TF
Novelty:  0.07020518
p_int:  0.9816344
p_ni:  0.01752341
p_wrong:  0.000842189
Score:  0.186
Data Source:  BioPlex,STRINGDB
RPS13
Tbio
Novelty:  0.0019983
p_int:  0.852436032
p_ni:  0.005914347
p_wrong:  0.141649621
Data Source:  BioPlex
APOBEC4
Tdark
Novelty:  0.13240154
Score:  0.978
Data Source:  STRINGDB
A1CF
Tbio
Novelty:  0.04151936
Score:  0.926
Data Source:  STRINGDB
APOBEC1
Tbio
Novelty:  0.00622042
Score:  0.922
Data Source:  STRINGDB
APOBEC3H
Tbio
Novelty:  0.01600106
Score:  0.919
Data Source:  STRINGDB
APOBEC3A
Tchem
Novelty:  0.00982993
Score:  0.913
Data Source:  STRINGDB
APOBEC2
Tbio
Novelty:  0.03447716
Score:  0.913
Data Source:  STRINGDB
Publication Statistics
PubMed Score  107.77

PubMed score by year
PubTator Score  33.2

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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