Tbio APOBEC3C DNA dC->dU-editing enzyme APOBEC-3C

Protein Summary

Description

DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single-or double-stranded RNA. Exhibits antiviral activity against simian immunodeficiency virus (SIV), hepatitis B virus (HBV), herpes simplex virus 1 (HHV-1) and Epstein-Barr virus (EBV) and may inhibit the mobility of LTR and non-LTR retrotransposons. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation. This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. It is thought that the proteins may be RNA editing enzymes and have roles in growth or cell cycle control. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9NRW3
• B2R884
• Q5JZ92
• Q7Z2N7
• Q96F12
• A3C

Gene Name

• APOBEC3C

Ensembl ID

• ENST00000361441
• ENSP00000355340
• ENSG00000244509

Symbol

• APOBEC1L
• PBI
• A3C
• PBI
• ARP5
• ARDC2
• ARDC4
• APOBEC1L
• bK150C2.3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	0.75
histone modification site profile	0.69
biological process	0.68
cell type or tissue	0.67
tissue sample	0.67

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Dna Dc->du-editing Enzyme Apobec-3c

Protein / Hydrolase / Deaminase / Dna Dc->du-editing Enzyme Apobec-3c

DTO Classes

Protein / Enzyme / Hydrolase / Deaminase / Dna Dc->du-editing Enzyme Apobec-3c

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 206.8   (req: < 5)

Gene RIFs: 50   (req: <= 3)

Antibodies: 232   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 206.8   (req: >= 5)

Gene RIFs: 50   (req: > 3)

Antibodies: 232   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0