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Tbio
RAB6B
Ras-related protein Rab-6B

Protein Summary
Description
Seems to have a role in retrograde membrane traffic at the level of the Golgi complex. May function in retrograde transport in neuronal cells.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000285208
  • ENSP00000285208
  • ENSG00000154917
  • ENST00000486858
  • ENSP00000419381
  • ENST00000543906
  • ENSP00000437797
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.95
kinase perturbation
0.84
transcription factor perturbation
0.84
PubMedID
0.79
gene perturbation
0.75


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.39   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 166   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.39   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 166   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
1
1
26.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
26.3
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
RAB6B, member RAS oncogene family
717431
Mouse
MGI:107283
270192
Cow
RAB6B, member RAS oncogene family
VGNC:50013
526526
Opossum
RAB6B, member RAS oncogene family
100015979
Zebrafish
ZDB-GENE-050809-136
558900
Species
Name
OMA
EggNOG
Inparanoid
Macaque
RAB6B, member RAS oncogene family
Mouse
Cow
RAB6B, member RAS oncogene family
Opossum
RAB6B, member RAS oncogene family
Zebrafish
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9NRW1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (12)
COPI-independent Golgi-to-ER retrograde traffic (R-HSA-6811436)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
COPI-independent Golgi-to-ER retrograde traffic
Reactome
Golgi-to-ER retrograde transport
Reactome
Intra-Golgi and retrograde Golgi-to-ER traffic
Reactome
Membrane Trafficking
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
COPI-independent Golgi-to-ER retrograde traffic
Golgi-to-ER retrograde transport
Intra-Golgi and retrograde Golgi-to-ER traffic
Membrane Trafficking
Metabolism of proteins
Gene Ontology Terms (14)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (189)
1 – 10 of 189
RAB6A
Tbio
Family: Enzyme
Novelty: 0.00546034
p_int: 0.999999936
p_ni: 5.7e-8
p_wrong: 7e-9
Score: 0.98
Data Source: BioPlex,STRINGDB
RAB6C
Tbio
Family: Enzyme
Novelty: 0.08908467
p_int: 0.999999789
p_ni: 8.5e-8
p_wrong: 1.26e-7
Score: 0.351
Data Source: BioPlex,STRINGDB
CHM
Tbio
Family: Enzyme
Novelty: 0.00226278
p_int: 0.999999406
p_ni: 5.93e-7
Score: 0.939
Data Source: BioPlex,STRINGDB
GDI1
Tbio
Novelty: 0.01710945
p_int: 0.999999208
p_ni: 7.92e-7
Score: 0.957
Data Source: BioPlex,STRINGDB
RAB41
Tdark
Family: Enzyme
p_int: 0.999998348
p_ni: 0.000001482
p_wrong: 1.7e-7
Score: 0.916
Data Source: BioPlex,STRINGDB
CHML
Tbio
Family: Enzyme
Novelty: 0.00509709
p_int: 0.999996732
p_ni: 0.000003267
Score: 0.939
Data Source: BioPlex,STRINGDB
SBF1
Tbio
Novelty: 0.01814482
p_int: 0.999981868
p_ni: 0.00001813
p_wrong: 2e-9
Score: 0.36
Data Source: BioPlex,STRINGDB
USP32
Tbio
Family: Enzyme
Novelty: 0.08043957
p_int: 0.999964399
p_ni: 0.000035601
Score: 0.246
Data Source: BioPlex,STRINGDB
CUL9
Tbio
Novelty: 0.1104365
p_int: 0.999855453
p_ni: 0.000144401
p_wrong: 1.46e-7
Score: 0.161
Data Source: BioPlex,STRINGDB
RABGGTA
Tdark
Family: Enzyme
Novelty: 0.19962321
p_int: 0.999712239
p_ni: 0.000287761
Score: 0.95
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  9.39

PubMed score by year
PubTator Score  6.1

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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