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Tbio
HEBP1
Heme-binding protein 1

Protein Summary
Description
May bind free porphyrinogens that may be present in the cell and thus facilitate removal of these potentially toxic compound. Binds with a high affinity to one molecule of heme or porphyrins. It binds metalloporphyrins, free porphyrins and N-methylprotoporphyrin with similar affinities. The full-length protein encoded by this gene is an intracellular tetrapyrrole-binding protein. This protein includes a natural chemoattractant peptide of 21 amino acids at the N-terminus, which is a natural ligand for formyl peptide receptor-like receptor 2 (FPRL2) and promotes calcium mobilization and chemotaxis in monocytes and dendritic cells. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000014930
  • ENSP00000014930
  • ENSG00000013583

Symbol
  • HBP
  • HBP
  • HEBP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
virus perturbation
0.88
transcription factor perturbation
0.8
histone modification site profile
0.77
gene perturbation
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.15   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 155   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.15   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 155   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (242)
1 – 10 of 242
FPR3
Tchem
Family:  GPCR
Novelty:  0.00899645
Score:  0.99
Data Source:  Reactome,STRINGDB
GNG8
Tdark
Novelty:  0.00590503
Score:  0.919
Data Source:  STRINGDB
FPR2
Tchem
Family:  GPCR
Novelty:  0.00228744
Score:  0.908
Data Source:  STRINGDB
GPR17
Tchem
Family:  GPCR
Novelty:  0.00545502
Score:  0.908
Data Source:  STRINGDB
GPR37L1
Tbio
Family:  GPCR
Novelty:  0.08467087
Score:  0.905
Data Source:  STRINGDB
APP
Tchem
Novelty:  0.00008964
Score:  0.904
Data Source:  STRINGDB
GNG10
Tdark
Novelty:  0.37659459
Score:  0.903
Data Source:  STRINGDB
GNG12
Tbio
Novelty:  0.12611933
Score:  0.903
Data Source:  STRINGDB
FPR1
Tchem
Family:  GPCR
Novelty:  0.00256884
Score:  0.902
Data Source:  STRINGDB
C5AR1
Tchem
Family:  GPCR
Novelty:  0.00188281
Score:  0.902
Data Source:  STRINGDB
Pathways (9)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
Formyl peptide receptors bind formyl peptides and many other ligands
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
Formyl peptide receptors bind formyl peptides and many other ligands
G alpha (i) signalling events
GPCR downstream signalling
GPCR ligand binding
Gene Ontology Terms (6)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hemoglobin measurement
3
2
3
90.9
heel bone mineral density
1
1
1
81.5
hematocrit
3
1
3
81.3
red blood cell density measurement
1
1
1
77.9
mean reticulocyte volume
1
1
1
70.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hemoglobin measurement
3
90.9
heel bone mineral density
1
81.5
hematocrit
3
81.3
red blood cell density measurement
1
77.9
mean reticulocyte volume
1
70.8
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
heme binding protein 1
VGNC:5415
473371
Macaque
heme binding protein 1
697821
Mouse
MGI:1333880
15199
Rat
RGD:1304581
362454
Dog
heme binding protein 1
VGNC:41639
477690
Species
Name
OMA
EggNOG
Inparanoid
Chimp
heme binding protein 1
Macaque
heme binding protein 1
Mouse
Rat
Dog
heme binding protein 1
Publication Statistics
PubMed Score 18.15
PubMed score by year
PubTator Score 309.87
PubTator score by year