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Tdark
CDC42SE1
CDC42 small effector protein 1

Protein Summary
Description
Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Alters CDC42-induced cell shape changes. In activated T-cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in early contractile events in phagocytosis in macrophages.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000357235
  • ENSP00000349773
  • ENSG00000197622
  • ENST00000439374
  • ENSP00000475845
  • ENST00000540998
  • ENSP00000445647

Symbol
  • SPEC1
  • SCIP1
  • SPEC1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
disease perturbation
0.97
transcription factor binding site profile
0.91
transcription factor perturbation
0.88
virus perturbation
0.83


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.92   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 9   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.92   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 9   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
2
2
2
37.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
2
37.7
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
CDC42 small effector 1
VGNC:10564
749171
Macaque
CDC42 small effector 1
100427784
Mouse
MGI:1889510
57912
Rat
RGD:1561700
499672
Dog
CDC42 small effector 1
VGNC:39005
608900
Species
Name
OMA
EggNOG
Inparanoid
Chimp
CDC42 small effector 1
Macaque
CDC42 small effector 1
Mouse
Rat
Dog
CDC42 small effector 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9NRR8-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (10)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (21)
1 – 10 of 21
MIPEP
Tbio
Family: Enzyme
Novelty: 0.01507033
p_int: 0.99996217
p_ni: 0.00003783
Score: 0.214
Data Source: BioPlex,STRINGDB
EIF5B
Tbio
Novelty: 0.00119991
p_int: 0.991447474
p_ni: 0.008552526
Score: 0.351
Data Source: BioPlex,STRINGDB
CDC42
Tchem
Family: Enzyme
Novelty: 0.00032619
p_int: 0.980589644
p_ni: 0.019410356
Score: 0.647
Data Source: BioPlex,STRINGDB
BTBD1
Tbio
Novelty: 0.19772296
p_int: 0.913413739
p_ni: 0.086586253
p_wrong: 9e-9
Score: 0.181
Data Source: BioPlex,STRINGDB
TMED2
Tbio
Novelty: 0.03731104
Score: 0.691
Data Source: STRINGDB
CD59
Tbio
Novelty: 0.0008352
Score: 0.678
Data Source: STRINGDB
PIGC
Tbio
Family: Enzyme
Novelty: 0.02057578
Score: 0.62
Data Source: STRINGDB
TPR
Tbio
Novelty: 0.00462503
Score: 0.572
Data Source: STRINGDB
PNPLA4
Tbio
Family: Enzyme
Novelty: 0.07471752
Score: 0.563
Data Source: STRINGDB
PARD6A
Tbio
Novelty: 0.05667035
Score: 0.519
Data Source: STRINGDB
Publication Statistics
PubMed Score  44.92

PubMed score by year
PubTator Score  19.03

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer