INPP5E
72 kDa inositol polyphosphate 5-phosphatase
Protein Summary
Converts phosphatidylinositol 3,4,5-trisphosphate (PtdIns 3,4,5-P3) to PtdIns-P2, and phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol 4-phosphate. Specific for lipid substrates, inactive towards water soluble inositol phosphates. The protein encoded by this gene is an inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase. InsP3 5-phosphatases hydrolyze Ins(1,4,5)P3, which mobilizes intracellular calcium and acts as a second messenger mediating cell responses to various stimulation. Studies of the mouse counterpart suggest that this protein may hydrolyze phosphatidylinositol 3,4,5-trisphosphate and phosphatidylinositol 3,5-bisphosphate on the cytoplasmic Golgi membrane and thereby regulate Golgi-vesicular trafficking. Mutations in this gene cause Joubert syndrome; a clinically and genetically heterogenous group of disorders characterized by midbrain-hindbrain malformation and various associated ciliopathies that include retinal dystrophy, nephronophthisis, liver fibrosis and ...more
- ENST00000371712
- ENSP00000360777
- ENSG00000148384
- CPD4
- CORS1
- JBTS1
- MORMS
- PPI5PIV
- pharbin
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
co-expressed gene | 0.87 | ||
virus perturbation | 0.83 | ||
kinase perturbation | 0.76 | ||
tissue sample | 0.7 | ||
cellular component | 0.62 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 18.59 (req: < 5)
Gene RIFs: 19 (req: <= 3)
Antibodies: 79 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 18.59 (req: >= 5)
Gene RIFs: 19 (req: > 3)
Antibodies: 79 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (77)
Nearest Tclin Targets (4)
Upstream (2)
Downstream (2)
1 – 2 of 2
Pathways (15)
Reactome (9)
KEGG (3)
PathwayCommons (1)
WikiPathways (2)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | ARL13B-mediated ciliary trafficking of INPP5E | ||||
Reactome | Cargo trafficking to the periciliary membrane | ||||
Reactome | Cilium Assembly | ||||
Reactome | Metabolism | ||||
Reactome | Metabolism of lipids | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
ARL13B-mediated ciliary trafficking of INPP5E | ||||
Cargo trafficking to the periciliary membrane | ||||
Cilium Assembly | ||||
Metabolism | ||||
Metabolism of lipids | ||||
Viral Interactions (0)
Gene Ontology Terms (11)
Functions (2)
Components (6)
Processes (3)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Traceable Author Statement (TAS) | UniProtKB | |||
Traceable Author Statement (TAS) | Reactome | |||
Disease Associations ()
GWAS Traits (40)
Items per page:
1 – 5 of 40
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
14 | 10 | 4 | 1.1 | 98.8 | |||||
3 | 4 | 1 | 1.2 | 96.3 | |||||
HbA1c measurement | 3 | 3 | 3 | 94.5 | |||||
2 | 2 | 0 | 1.2 | 93.4 | |||||
4 | 4 | 1 | 1.1 | 92.6 | |||||
Items per page:
1 – 5 of 40
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
4 | 1.1 | 98.8 | |||||
1 | 1.2 | 96.3 | |||||
HbA1c measurement | 3 | 94.5 | |||||
0 | 1.2 | 93.4 | |||||
1 | 1.1 | 92.6 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | inositol polyphosphate-5-phosphatase E | 748603 | ||||||
Macaque | inositol polyphosphate-5-phosphatase E | 710121 | ||||||
Mouse | MGI:1927753 | 64436 | ||||||
Rat | RGD:620478 | 114089 | ||||||
Dog | inositol polyphosphate-5-phosphatase E | VGNC:42033 | 607443 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | inositol polyphosphate-5-phosphatase E | |||||
Macaque | inositol polyphosphate-5-phosphatase E | |||||
Mouse | ||||||
Rat | ||||||
Dog | inositol polyphosphate-5-phosphatase E | |||||
Publication Statistics
PubMed Score 18.59
PubMed score by year
PubTator Score 45.81
PubTator score by year
Related Publications
Text Mined References (24)
GeneRif Annotations (19)
Items per page:
0 of 0
PMID | Year | Title |
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