INPP5E
72 kDa inositol polyphosphate 5-phosphatase
Protein Summary
Converts phosphatidylinositol 3,4,5-trisphosphate (PtdIns 3,4,5-P3) to PtdIns-P2, and phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol 4-phosphate. Specific for lipid substrates, inactive towards water soluble inositol phosphates. The protein encoded by this gene is an inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase. InsP3 5-phosphatases hydrolyze Ins(1,4,5)P3, which mobilizes intracellular calcium and acts as a second messenger mediating cell responses to various stimulation. Studies of the mouse counterpart suggest that this protein may hydrolyze phosphatidylinositol 3,4,5-trisphosphate and phosphatidylinositol 3,5-bisphosphate on the cytoplasmic Golgi membrane and thereby regulate Golgi-vesicular trafficking. Mutations in this gene cause Joubert syndrome; a clinically and genetically heterogenous group of disorders characterized by midbrain-hindbrain malformation and various associated ciliopathies that include retinal dystrophy, nephronophthisis, liver fibrosis and ...more
- ENST00000371712
- ENSP00000360777
- ENSG00000148384
- CPD4
- CORS1
- JBTS1
- MORMS
- PPI5PIV
- pharbin
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
co-expressed gene | 0.87 | ||
virus perturbation | 0.83 | ||
kinase perturbation | 0.76 | ||
tissue sample | 0.7 | ||
cellular component | 0.62 | ||
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 17.25 (req: < 5)
Gene RIFs: 19 (req: <= 3)
Antibodies: 79 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 17.25 (req: >= 5)
Gene RIFs: 19 (req: > 3)
Antibodies: 79 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
GWAS Traits (6)
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
neutrophil count | 2 | 1 | 2 | 82.9 | |||||
myeloid white cell count | 1 | 1 | 1 | 82.5 | |||||
leukocyte count | 1 | 1 | 1 | 52.3 | |||||
red blood cell distribution width | 1 | 1 | 1 | 29 | |||||
HbA1c measurement | 1 | 1 | 1 | 26.1 | |||||
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
neutrophil count | 2 | 82.9 | |||||
myeloid white cell count | 1 | 82.5 | |||||
leukocyte count | 1 | 52.3 | |||||
red blood cell distribution width | 1 | 29 | |||||
HbA1c measurement | 1 | 26.1 | |||||
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | inositol polyphosphate-5-phosphatase E | 748603 | ||||||
Macaque | inositol polyphosphate-5-phosphatase E | 710121 | ||||||
Mouse | MGI:1927753 | 64436 | ||||||
Rat | RGD:620478 | 114089 | ||||||
Dog | inositol polyphosphate-5-phosphatase E | VGNC:42033 | 607443 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | inositol polyphosphate-5-phosphatase E | |||||
Macaque | inositol polyphosphate-5-phosphatase E | |||||
Mouse | ||||||
Rat | ||||||
Dog | inositol polyphosphate-5-phosphatase E | |||||
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id | Ligand | Method | Resolution (Å) | M.W. (kDa) | Pub Year | Title |
|---|
PDB Structure Id | M.W. | Resolution | Pub Year |
|---|
Pathways (15)
Reactome (9)
KEGG (3)
PathwayCommons (1)
WikiPathways (2)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 9
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | ARL13B-mediated ciliary trafficking of INPP5E | ||||
Reactome | Cargo trafficking to the periciliary membrane | ||||
Reactome | Cilium Assembly | ||||
Reactome | Metabolism | ||||
Reactome | Metabolism of lipids | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
ARL13B-mediated ciliary trafficking of INPP5E | ||||
Cargo trafficking to the periciliary membrane | ||||
Cilium Assembly | ||||
Metabolism | ||||
Metabolism of lipids | ||||
Gene Ontology Terms (11)
Functions (2)
Components (6)
Processes (3)
Items per page:
10
1 – 2 of 2
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Traceable Author Statement (TAS) | UniProtKB | |||
Traceable Author Statement (TAS) | Reactome | |||
Protein-Protein Interactions (77)
1 – 10 of 77
SACM1L
Family: Enzyme
Novelty: 0.00499867
Score: 0.974
Data Source: STRINGDB
ARL13B
Family: Enzyme
Novelty: 0.01481674
Score: 0.964
Data Source: Reactome,STRINGDB
PDE6D
Family: Enzyme
Novelty: 0.02276328
Score: 0.947
Data Source: Reactome,STRINGDB
INPP4A
Family: Enzyme
Novelty: 0.03714963
Score: 0.94
Data Source: STRINGDB
PIP5KL1
Family: Enzyme
Novelty: 0.15208771
Score: 0.933
Data Source: STRINGDB
INPP4B
Family: Enzyme
Novelty: 0.02053228
Score: 0.93
Data Source: STRINGDB
TPTE2
Family: Enzyme
Novelty: 0.04710658
Score: 0.911
Data Source: STRINGDB
PTEN
Family: Enzyme
Novelty: 0.00013818
Score: 0.911
Data Source: STRINGDB
PIP5K1B
Family: Kinase
Novelty: 0.05013433
Score: 0.897
Data Source: STRINGDB
PIP5K1C
Family: Kinase
Novelty: 0.0323077
Score: 0.888
Data Source: STRINGDB
Publication Statistics
PubMed Score 17.25
PubMed score by year
PubTator Score 45.81
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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