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Tbio
INPP5E
72 kDa inositol polyphosphate 5-phosphatase

Protein Summary
Description
Converts phosphatidylinositol 3,4,5-trisphosphate (PtdIns 3,4,5-P3) to PtdIns-P2, and phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol 4-phosphate. Specific for lipid substrates, inactive towards water soluble inositol phosphates. The protein encoded by this gene is an inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase. InsP3 5-phosphatases hydrolyze Ins(1,4,5)P3, which mobilizes intracellular calcium and acts as a second messenger mediating cell responses to various stimulation. Studies of the mouse counterpart suggest that this protein may hydrolyze phosphatidylinositol 3,4,5-trisphosphate and phosphatidylinositol 3,5-bisphosphate on the cytoplasmic Golgi membrane and thereby regulate Golgi-vesicular trafficking. Mutations in this gene cause Joubert syndrome; a clinically and genetically heterogenous group of disorders characterized by midbrain-hindbrain malformation and various associated ciliopathies that include retinal dystrophy, nephronophthisis, liver fibrosis and ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000371712
  • ENSP00000360777
  • ENSG00000148384

Symbol
  • CPD4
  • CORS1
  • JBTS1
  • MORMS
  • PPI5PIV
  • pharbin
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.87
virus perturbation
0.83
kinase perturbation
0.76
tissue sample
0.7
cellular component
0.62


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.25   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 79   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.25   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 79   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
2
1
2
82.9
myeloid white cell count
1
1
1
82.5
leukocyte count
1
1
1
52.3
red blood cell distribution width
1
1
1
29
HbA1c measurement
1
1
1
26.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
2
82.9
myeloid white cell count
1
82.5
leukocyte count
1
52.3
red blood cell distribution width
1
29
HbA1c measurement
1
26.1
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
inositol polyphosphate-5-phosphatase E
748603
Macaque
inositol polyphosphate-5-phosphatase E
710121
Mouse
MGI:1927753
64436
Rat
RGD:620478
114089
Dog
inositol polyphosphate-5-phosphatase E
VGNC:42033
607443
Species
Name
OMA
EggNOG
Inparanoid
Chimp
inositol polyphosphate-5-phosphatase E
Macaque
inositol polyphosphate-5-phosphatase E
Mouse
Rat
Dog
inositol polyphosphate-5-phosphatase E
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9NRR6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (15)
ARL13B-mediated ciliary trafficking of INPP5E (R-HSA-5624958)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ARL13B-mediated ciliary trafficking of INPP5E
Reactome
Cargo trafficking to the periciliary membrane
Reactome
Cilium Assembly
Reactome
Metabolism
Reactome
Metabolism of lipids
Name
Explore in Pharos
Explore in Source
ARL13B-mediated ciliary trafficking of INPP5E
Cargo trafficking to the periciliary membrane
Cilium Assembly
Metabolism
Metabolism of lipids
Protein-Protein Interactions (77)
1 – 10 of 77
SACM1L
Tbio
Family: Enzyme
Novelty: 0.00499867
Score: 0.974
Data Source: STRINGDB
ARL13B
Tbio
Family: Enzyme
Novelty: 0.01481674
Score: 0.964
Data Source: Reactome,STRINGDB
PDE6D
Tclin
Family: Enzyme
Novelty: 0.02276328
Score: 0.947
Data Source: Reactome,STRINGDB
INPP4A
Tbio
Family: Enzyme
Novelty: 0.03714963
Score: 0.94
Data Source: STRINGDB
PIP5KL1
Tbio
Family: Enzyme
Novelty: 0.15208771
Score: 0.933
Data Source: STRINGDB
INPP4B
Tbio
Family: Enzyme
Novelty: 0.02053228
Score: 0.93
Data Source: STRINGDB
TPTE2
Tbio
Family: Enzyme
Novelty: 0.04710658
Score: 0.911
Data Source: STRINGDB
PTEN
Tchem
Family: Enzyme
Novelty: 0.00013818
Score: 0.911
Data Source: STRINGDB
PIP5K1B
Tbio
Family: Kinase
Novelty: 0.05013433
Score: 0.897
Data Source: STRINGDB
PIP5K1C
Tchem
Family: Kinase
Novelty: 0.0323077
Score: 0.888
Data Source: STRINGDB
Publication Statistics
PubMed Score  17.25

PubMed score by year
PubTator Score  45.81

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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