Tbio DROSHA Ribonuclease 3

Protein Summary

Description

Ribonuclease III double-stranded (ds) RNA-specific endoribonuclease that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DROSHA cleaves the 3' and 5' strands of a stem-loop in pri-miRNAs (processing center 11 bp from the dsRNA-ssRNA junction) to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs. Involved also in pre-rRNA processing. Cleaves double-strand RNA and does not cleave single-strand RNA. Involved in the formation of GW bodies. This gene encodes a ribonuclease (RNase) III double-stranded RNA-specific ribonuclease and subunit of the microprocessor protein complex, which catalyzes the initial processing step of microRNA (miRNA) synthesis. The encoded protein cleaves the stem loop structure from the primary microRNA (pri-miRNA) in the nucleus, yielding the precursor miRNA (pre-miRNA), which is then exported to the cytoplasm for further processing. In a human cell line lacking a functional copy of this gene, canonical miRNA synthesis is reduced. Somatic mutations in this gene have been observed in human patients with kidney cancer. [provided by RefSeq, Sep 2016]

Uniprot Accession IDs

• Q9NRR4
• E7EMP9
• Q7Z5V2
• Q86YH0
• Q9NW73
• Q9Y2V9
• Q9Y4Y0

Gene Name

• DROSHA

Ensembl ID

• ENST00000344624
• ENSP00000339845
• ENSG00000113360
• ENST00000442743
• ENSP00000409335
• ENST00000511367
• ENSP00000425979
• ENST00000513349
• ENSP00000424161

Symbol

• RN3
• RNASE3L
• RNASEN
• RN3
• ETOHI2
• RNASEN
• RANSE3L
• RNASE3L
• HSA242976

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.92
kinase perturbation	0.91
molecular function	0.91
ligand (protein) perturbation	0.83
transcription factor binding site profile	0.81

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Nuclease / Endoribonuclease / Ribonuclease 3

Protein / Nucleic Acid Binding / Rna Binding Protein / Endoribonuclease / Ribonuclease 3

DTO Classes

Protein / Enzyme / Nuclease / Endoribonuclease / Ribonuclease 3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1035.66   (req: < 5)

Gene RIFs: 156   (req: <= 3)

Antibodies: 256   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1035.66   (req: >= 5)

Gene RIFs: 156   (req: > 3)

Antibodies: 256   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0