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Tbio
DROSHA
Ribonuclease 3

Protein Summary
Description
Ribonuclease III double-stranded (ds) RNA-specific endoribonuclease that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DROSHA cleaves the 3' and 5' strands of a stem-loop in pri-miRNAs (processing center 11 bp from the dsRNA-ssRNA junction) to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs. Involved also in pre-rRNA processing. Cleaves double-strand RNA and does not cleave single-strand RNA. Involved in the formation of GW bodies. This gene encodes a ribonuclease (RNase) III double-stranded RNA-specific ribonuclease and subunit of the microprocessor protein complex, which catalyzes the initial processing step of microRNA (miRNA) synthesis. The encoded protein cleaves the stem loop structure from the primary micr ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000344624
  • ENSP00000339845
  • ENSG00000113360
  • ENST00000442743
  • ENSP00000409335
  • ENST00000511367
  • ENSP00000425979
  • ENST00000513349
  • ENSP00000424161

Symbol
  • RN3
  • RNASE3L
  • RNASEN
  • RN3
  • ETOHI2
  • RNASEN
  • RANSE3L
  • RNASE3L
  • HSA242976
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.92
kinase perturbation
0.91
molecular function
0.91
ligand (protein) perturbation
0.83
transcription factor binding site profile
0.81


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 870.32   (req: < 5)
Gene RIFs: 117   (req: <= 3)
Antibodies: 256   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 870.32   (req: >= 5)
Gene RIFs: 117   (req: > 3)
Antibodies: 256   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (308)
DGCR8
Tbio
Novelty:  0.00271221
p_int:  0.999999981
p_ni:  1.9e-8
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
ERH
Tbio
Novelty:  0.00711649
p_int:  0.999757433
p_ni:  0.000242566
p_wrong:  1e-9
Data Source:  BioPlex
SRPK1
Tchem
Family:  Kinase
Novelty:  0.01066655
p_int:  0.995696048
p_ni:  0.004303952
Score:  0.826
Data Source:  BioPlex,STRINGDB
CHRNA9
Tchem
Family:  IC
Novelty:  0.05009815
p_int:  0.974125679
p_ni:  0.025874234
p_wrong:  8.7e-8
Score:  0.187
Data Source:  BioPlex,STRINGDB
DDX5
Tbio
Family:  Enzyme
Novelty:  0.00637984
Score:  0.989
Data Source:  STRINGDB
TP53
Tchem
Family:  TF
Novelty:  0.00001907
Score:  0.985
Data Source:  STRINGDB
AGO2
Tbio
Novelty:  0.00057003
Score:  0.981
Data Source:  STRINGDB
AGO1
Tbio
Novelty:  0.00157424
Score:  0.971
Data Source:  STRINGDB
XPO5
Tbio
Novelty:  0.0040002
Score:  0.97
Data Source:  STRINGDB
TARBP2
Tbio
Novelty:  0.01485994
Score:  0.968
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (10)
Gene Silencing by RNA (R-HSA-211000)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene Silencing by RNA
Reactome
Gene expression (Transcription)
Reactome
MicroRNA (miRNA) biogenesis
Name
Explore in Pharos
Explore in Source
Gene Silencing by RNA
Gene expression (Transcription)
MicroRNA (miRNA) biogenesis
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (28)
Find Similar Targets
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
WormBase
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
1
1
17.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
17.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
drosha ribonuclease III
VGNC:6858
471576
Macaque
drosha ribonuclease III
692081
Mouse
MGI:1261425
14000
Rat
RGD:1307626
310159
Horse
drosha ribonuclease III
VGNC:17318
100054238
Species
Name
OMA
EggNOG
Inparanoid
Chimp
drosha ribonuclease III
Macaque
drosha ribonuclease III
Mouse
Rat
Horse
drosha ribonuclease III
Publication Statistics
PubMed Score 870.32
PubMed score by year
PubTator Score 381.98
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title