Tbio CDC42SE2 CDC42 small effector protein 2

Protein Summary

Description

Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Alters CDC42-induced cell shape changes. In activated T-cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in early contractile events in phagocytosis in macrophages.

Uniprot Accession IDs

• Q9NRR3
• B2R622
• Q4KMT9

Gene Name

• CDC42SE2

Ensembl ID

• ENST00000360515
• ENSP00000353706
• ENSG00000158985
• ENST00000395246
• ENSP00000378667
• ENST00000505065
• ENSP00000427421

Symbol

• SPEC2
• SPEC2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.88
disease perturbation	0.83
histone modification site profile	0.76
transcription factor binding site profile	0.76
interacting protein	0.71

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.83   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 68   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.83   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 68   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0