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Tchem
TPSG1
Tryptase gamma

Protein Summary
Description
Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. There is uncertainty regarding the number of genes in this cluster. Currently four functional genes - alpha I, beta I, beta II and gamma I - have been identified. And beta I has an allelic variant named alpha II, beta II has an allelic variant beta III, also gamma I has an allelic variant gamma II. Beta tryptases appear to be the main isoenzymes expressed in mast cells; whereas in basophils, alpha-tryptases predominant. This gene differs from other members of the tryptase gene family in that it has C-terminal hydrophobic domain, which may serve as a membrane anchor. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders. [provided by Ref ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000234798
  • ENSP00000234798
  • ENSG00000116176

Symbol
  • PRSS31
  • TMT
  • TMT
  • trpA
  • PRSS31
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.88
protein domain
0.58
tissue
0.53
cell type or tissue
0.52
cellular component
0.45


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.69   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 174   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.69   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 174   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Gene Ontology Terms (5)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (5)
1 – 5 of 5
HCN2
Tclin
Family: IC
Novelty: 0.0314591
Score: 0.675
Data Source: STRINGDB
CPA3
Tchem
Family: Enzyme
Novelty: 0.02198512
Score: 0.516
Data Source: STRINGDB
CPA4
Tbio
Family: Enzyme
Novelty: 0.01862158
Score: 0.506
Data Source: STRINGDB
NMU
Tbio
Novelty: 0.00347523
Score: 0.473
Data Source: STRINGDB
POTEI
Tdark
Novelty: 0.30601093
Score: 0.416
Data Source: STRINGDB
Publication Statistics
PubMed Score  20.69

PubMed score by year
PubTator Score  78.88

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer