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Tbio
PLSCR4
Phospholipid scramblase 4

Protein Summary
Description
May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000354952
  • ENSP00000347038
  • ENSG00000114698
  • ENST00000433593
  • ENSP00000415605
  • ENST00000446574
  • ENSP00000399315
  • ENST00000493382
  • ENSP00000419040

Symbol
  • TRA1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
metabolite
0.98
gene perturbation
0.87
microRNA
0.72
virus perturbation
0.64
histone modification site profile
0.62


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.26   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 117   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.26   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 117   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (27)
1 – 10 of 27
ZDHHC17
Tbio
Family:  Enzyme
Novelty:  0.03288707
p_int:  0.998592935
p_ni:  0.001407065
Score:  0.252
Data Source:  BioPlex,STRINGDB
FBLN1
Tbio
Novelty:  0.00796703
p_int:  0.942532961
p_ni:  0.057467039
Score:  0.263
Data Source:  BioPlex,STRINGDB
IGHG2
Tclin
p_int:  0.782615603
p_ni:  0.217318535
p_wrong:  0.000065862
Data Source:  BioPlex
ALG13
Tbio
Family:  Enzyme
Novelty:  0.04054611
p_int:  0.750876145
p_ni:  0.249123855
Score:  0.29
Data Source:  BioPlex,STRINGDB
ANO6
Tbio
Family:  IC
Novelty:  0.01288434
Score:  0.72
Data Source:  STRINGDB
XKR8
Tbio
Novelty:  0.08472323
Score:  0.684
Data Source:  STRINGDB
ANO3
Tbio
Novelty:  0.02326536
Score:  0.666
Data Source:  STRINGDB
ANO2
Tchem
Family:  IC
Novelty:  0.01239394
Score:  0.656
Data Source:  STRINGDB
MUC4
Tbio
Novelty:  0.00193208
Score:  0.622
Data Source:  STRINGDB
ANO9
Tbio
Novelty:  0.16467408
Score:  0.592
Data Source:  STRINGDB
Gene Ontology Terms (9)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
2
2
74.1
hematocrit
1
1
1
8.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
74.1
hematocrit
1
8.5
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
phospholipid scramblase 4
VGNC:2515
460755
Macaque
phospholipid scramblase 4
713430
Mouse
MGI:2143267
235527
Rat
RGD:1311693
300900
Dog
phospholipid scramblase 4
VGNC:44713
611495
Species
Name
OMA
EggNOG
Inparanoid
Chimp
phospholipid scramblase 4
Macaque
phospholipid scramblase 4
Mouse
Rat
Dog
phospholipid scramblase 4
Publication Statistics
PubMed Score 9.26
PubMed score by year
PubTator Score 138.08
PubTator score by year