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Tbio
STK36
Serine/threonine-protein kinase 36

Protein Summary
Description
Serine/threonine protein kinase which plays an important role in the sonic hedgehog (Shh) pathway by regulating the activity of GLI transcription factors (PubMed:10806483). Controls the activity of the transcriptional regulators GLI1, GLI2 and GLI3 by opposing the effect of SUFU and promoting their nuclear localization (PubMed:10806483). GLI2 requires an additional function of STK36 to become transcriptionally active, but the enzyme does not need to possess an active kinase catalytic site for this to occur (PubMed:10806483). Required for postnatal development, possibly by regulating the homeostasis of cerebral spinal fluid or ciliary function (By similarity). Essential for construction of the central pair apparatus of motile cilia. This gene encodes a member of the serine/threonine kinase family of enzymes. This family member is similar to a Drosophila protein that plays a key role in the Hedgehog signaling pathway. This human protein is a positive regulator of the GLI zinc-finger tran ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000295709
  • ENSP00000295709
  • ENSG00000163482
  • ENST00000392105
  • ENSP00000375954
  • ENST00000440309
  • ENSP00000394095

Symbol
  • KIAA1278
  • FU
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.96
protein domain
0.92
histone modification site profile
0.91
cell type or tissue
0.76
small molecule
0.75


Related Tools
Dark Kinase Knowledgebase
The Dark Kinase Knowledgebase is an an online compendium of knowledge and experimental results of understudied kinases.
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.53   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 166   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.53   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 166   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hemoglobin measurement
2
2
2
65.3
hematocrit
1
1
1
45.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hemoglobin measurement
2
65.3
hematocrit
1
45.5
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
serine/threonine kinase 36
VGNC:2874
459948
Macaque
serine/threonine kinase 36
699940
Mouse
MGI:1920831
269209
Rat
RGD:1307318
301516
Dog
serine/threonine kinase 36
VGNC:46918
478913
Species
Name
OMA
EggNOG
Inparanoid
Chimp
serine/threonine kinase 36
Macaque
serine/threonine kinase 36
Mouse
Rat
Dog
serine/threonine kinase 36
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9NRP7-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (16)
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
PathwayCommons: panther
Hedgehog signaling pathway
PathwayCommons: netpath
Hedgehog
PathwayCommons: pid
Hedgehog signaling events mediated by Gli proteins
Name
Explore in Pharos
Explore in Source
Hedgehog signaling pathway
Hedgehog
Hedgehog signaling events mediated by Gli proteins
Protein-Protein Interactions (81)
1 – 10 of 81
ECT2
Tbio
Novelty: 0.00834186
p_int: 0.99992053
p_ni: 4e-9
p_wrong: 0.000079465
Data Source: BioPlex
HSP90AA5P
Tdark
p_int: 0.999860425
p_ni: 0.000139575
Data Source: BioPlex
MUL1
Tbio
Family: Enzyme
Novelty: 0.00841786
p_int: 0.98931773
p_ni: 0.009820483
p_wrong: 0.000861787
Data Source: BioPlex
FCGRT
Tchem
Novelty: 0.00105713
p_int: 0.986675876
p_ni: 0.013298687
p_wrong: 0.000025437
Data Source: BioPlex
CITED1
Tbio
Novelty: 0.01956689
p_int: 0.981522786
p_ni: 0.018477212
p_wrong: 1e-9
Data Source: BioPlex
STARD3
Tbio
Novelty: 0.01540936
p_int: 0.952440075
p_ni: 0.047531365
p_wrong: 0.00002856
Data Source: BioPlex
ARAF
Tchem
Family: Kinase
Novelty: 0.00432488
p_int: 0.934724605
p_ni: 0.065275395
Data Source: BioPlex
RIPK4
Tchem
Family: Kinase
Novelty: 0.00818379
p_int: 0.905958506
p_ni: 0.093301012
p_wrong: 0.000740481
Data Source: BioPlex
ACVR1B
Tchem
Family: Kinase
Novelty: 0.00633595
p_int: 0.826515812
p_ni: 0.173482665
p_wrong: 0.000001523
Score: 0.185
Data Source: BioPlex,STRINGDB
ERBB2
Tclin
Family: Kinase
Novelty: 0.00003761
p_int: 0.796815033
p_ni: 0.203184967
Data Source: BioPlex
Publication Statistics
PubMed Score  8.53

PubMed score by year
PubTator Score  3.03

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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