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Tbio
AASDHPPT
L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase

Protein Classes
Protein Summary
Description
Catalyzes the post-translational modification of target proteins by phosphopantetheine. Can transfer the 4'-phosphopantetheine moiety from coenzyme A to a serine residue of a broad range of acceptors, such as the acyl carrier domain of FASN. The protein encoded by this gene is similar to Saccharomyces cerevisiae LYS5, which is required for the activation of the alpha-aminoadipate dehydrogenase in the biosynthetic pathway of lysine. Yeast alpha-aminoadipate dehydrogenase converts alpha-biosynthetic-aminoadipate semialdehyde to alpha-aminoadipate. It has been suggested that defects in the human gene result in pipecolic acidemia. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000278618
  • ENSP00000278618
  • ENSG00000149313
  • ENST00000525660
  • ENSP00000437144

Symbol
  • ACPS
  • LYS2
  • LYS5
  • CGI-80
  • AASD-PPT
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.88
histone modification site profile
0.85
transcription factor binding site profile
0.81
hub protein
0.67
microRNA
0.64


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 201.38   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 193   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 201.38   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 193   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (7)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of vitamins and cofactors
Reactome
Metabolism of water-soluble vitamins and cofactors
Reactome
Vitamin B5 (pantothenate) metabolism
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of vitamins and cofactors
Metabolism of water-soluble vitamins and cofactors
Vitamin B5 (pantothenate) metabolism
Protein-Protein Interactions (70)
1 – 10 of 70
ANGPTL4
Tbio
Novelty: 0.00237867
p_int: 0.981770618
p_ni: 0.018229382
Score: 0.19
Data Source: BioPlex,STRINGDB
PPP1R3C
Tbio
Family: Enzyme
Novelty: 0.01784199
p_int: 0.974005856
p_ni: 0.025994144
Score: 0.199
Data Source: BioPlex,STRINGDB
USP22
Tbio
Family: Enzyme
Novelty: 0.01416662
p_int: 0.957807544
p_ni: 0.042192456
Score: 0.254
Data Source: BioPlex,STRINGDB
POTEI
Tdark
Novelty: 0.41311202
p_int: 0.945522018
p_ni: 0.054477981
p_wrong: 2e-9
Score: 0.317
Data Source: BioPlex,STRINGDB
ANKRD39
Tdark
Novelty: 8.68843298
p_int: 0.752080762
p_ni: 0.247919238
Data Source: BioPlex
FASN
Tchem
Family: Enzyme
Novelty: 0.00142172
Score: 0.99
Data Source: Reactome,STRINGDB
AASDH
Tbio
Family: Enzyme
Novelty: 0.17181708
Score: 0.964
Data Source: STRINGDB
COASY
Tbio
Family: Enzyme
Novelty: 0.00294867
Score: 0.945
Data Source: STRINGDB
AASS
Tbio
Family: Enzyme
Novelty: 0.03213727
Score: 0.929
Data Source: STRINGDB
NDUFAB1
Tclin
Novelty: 0.00190242
Score: 0.886
Data Source: STRINGDB
Publication Statistics
PubMed Score  201.38

PubMed score by year
PubTator Score  91.28

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer