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Tchem
LATS2
Serine/threonine-protein kinase LATS2

Protein Summary
Description
Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in centrosome duplication, maintenance of mitotic fidelity and genomic stability. Negatively regulates G1/S transition by down-regulating cyclin E/CDK2 kinase activity. Negative regulator of the androgen receptor. Phosphorylates SNAI1 in the nucleus leading to its nuclear retention and stabilizatio ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000382592
  • ENSP00000372035
  • ENSG00000150457

Symbol
  • KPM
  • KPM
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
molecular function
0.94
transcription factor binding site profile
0.91
PubMedID
0.86
small molecule perturbation
0.84


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 199.64   (req: < 5)
Gene RIFs: 82   (req: <= 3)
Antibodies: 294   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 199.64   (req: >= 5)
Gene RIFs: 82   (req: > 3)
Antibodies: 294   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 18
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (123)
1 – 10 of 123
MOB1B
Tbio
Family:  Enzyme
Novelty:  0.0718959
p_int:  1
Score:  0.997
Data Source:  BioPlex,Reactome,STRINGDB
MOB1A
Tbio
Family:  Enzyme
Novelty:  0.01430129
Score:  0.996
Data Source:  Reactome,STRINGDB
YAP1
Tchem
Novelty:  0.00124225
Score:  0.996
Data Source:  Reactome,STRINGDB
SAV1
Tbio
Novelty:  0.00962335
Score:  0.994
Data Source:  STRINGDB
NF2
Tbio
Novelty:  0.00055092
Score:  0.992
Data Source:  STRINGDB
WWC1
Tbio
Novelty:  0.00905646
Score:  0.991
Data Source:  Reactome,STRINGDB
AMOTL2
Tbio
Novelty:  0.04258164
Score:  0.985
Data Source:  STRINGDB
WWTR1
Tbio
Novelty:  0.00431186
Score:  0.978
Data Source:  Reactome,STRINGDB
AMOTL1
Tbio
Novelty:  0.03842225
Score:  0.966
Data Source:  STRINGDB
STK4
Tchem
Family:  Kinase
Novelty:  0.02104423
Score:  0.965
Data Source:  Reactome,STRINGDB
Pathways (11)
Signal Transduction (R-HSA-162582)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Signal Transduction
Reactome
Signaling by Hippo
Name
Explore in Pharos
Explore in Source
Signal Transduction
Signaling by Hippo
Gene Ontology Terms (18)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
systolic blood pressure
1
1
1
38.8
BMI-adjusted hip circumference
1
1
1
28.1
mathematical ability
1
1
1
4.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
systolic blood pressure
1
38.8
BMI-adjusted hip circumference
1
28.1
mathematical ability
1
4.6
Find similar targets by:
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
large tumor suppressor kinase 2
VGNC:9840
452466
Macaque
large tumor suppressor kinase 2
699957
Mouse
MGI:1354386
50523
Rat
RGD:1305906
305922
Dog
large tumor suppressor kinase 2
VGNC:42599
477343
Species
Name
OMA
EggNOG
Inparanoid
Chimp
large tumor suppressor kinase 2
Macaque
large tumor suppressor kinase 2
Mouse
Rat
Dog
large tumor suppressor kinase 2
Publication Statistics
PubMed Score 199.64
PubMed score by year
PubTator Score 102.95
PubTator score by year
Patents
Patents by year