SLC2A9
Solute carrier family 2, facilitated glucose transporter member 9
Protein Summary
Transport urate and fructose. May have a role in the urate reabsorption by proximal tubules. Also transports glucose at low rate. This gene encodes a member of the SLC2A facilitative glucose transporter family. Members of this family play a significant role in maintaining glucose homeostasis. The encoded protein may play a role in the development and survival of chondrocytes in cartilage matrices. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
- ENST00000264784
- ENSP00000264784
- ENSG00000109667
- ENST00000309065
- ENSP00000311383
- ENST00000506583
- ENSP00000422209
- GLUT9
- GLUT9
- GLUTX
- UAQTL2
- URATv1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
cell type or tissue | 0.74 | ||
disease | 0.73 | ||
biological term | 0.7 | ||
molecular function | 0.7 | ||
phenotype | 0.64 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 170.3 (req: < 5)
Gene RIFs: 123 (req: <= 3)
Antibodies: 264 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 170.3 (req: >= 5)
Gene RIFs: 123 (req: > 3)
Antibodies: 264 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (126)
ZNF136
Family: TF
Novelty: 0.68698067
p_int: 0.999992725
p_ni: 8e-9
p_wrong: 0.000007267
Data Source: BioPlex
HIP1R
Novelty: 0.02502713
p_int: 0.998275075
p_ni: 0.001724923
p_wrong: 2e-9
Data Source: BioPlex
ZWILCH
Novelty: 0.05184569
p_int: 0.997919223
p_ni: 0.002029387
p_wrong: 0.000051391
Data Source: BioPlex
SLC25A46
Family: Transporter
Novelty: 0.02720146
p_int: 0.987983251
p_ni: 0.012016736
p_wrong: 1.3e-8
Data Source: BioPlex
STK17B
Family: Kinase
Novelty: 0.0420158
p_int: 0.976688407
p_ni: 0.022939643
p_wrong: 0.00037195
Data Source: BioPlex
RAI2
Novelty: 0.09286714
p_int: 0.96895135
p_ni: 7.44e-7
p_wrong: 0.031047905
Data Source: BioPlex
MTX3
Novelty: 0.06082176
p_int: 0.961017058
p_ni: 0.038981801
p_wrong: 0.000001141
Data Source: BioPlex
INTS12
Family: Epigenetic
Novelty: 0.09023473
p_int: 0.953989674
p_ni: 0.046010324
p_wrong: 2e-9
Data Source: BioPlex
Nearest Tclin Targets
Pathways (26)
Reactome (7)
WikiPathways (19)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cellular hexose transport | ||||
Reactome | Defective SLC2A9 causes hypouricemia renal 2 (RHUC2) | ||||
Reactome | Disease | ||||
Reactome | Disorders of transmembrane transporters | ||||
Reactome | SLC transporter disorders | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cellular hexose transport | ||||
Defective SLC2A9 causes hypouricemia renal 2 (RHUC2) | ||||
Disease | ||||
Disorders of transmembrane transporters | ||||
SLC transporter disorders | ||||
Viral Interactions (0)
Gene Ontology Terms (11)
Functions (4)
Components (4)
Processes (3)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Traceable Author Statement (TAS) | Reactome | |||
Non-traceable Author Statement (NAS) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations ()
GWAS Traits (29)
Items per page:
1 – 5 of 29
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
urate measurement | 18 | 52 | 59 | 9.3 | 100 | ||||
uric acid measurement | 18 | 16 | 25 | 15.7 | 99.9 | ||||
blood metabolite measurement | 2 | 3 | 3 | 97.2 | |||||
8 | 4 | 0 | 1.6 | 96.1 | |||||
low density lipoprotein cholesterol measurement | 2 | 2 | 2 | 94.2 | |||||
Items per page:
1 – 5 of 29
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
urate measurement | 59 | 9.3 | 100 | ||||
uric acid measurement | 25 | 15.7 | 99.9 | ||||
blood metabolite measurement | 3 | 97.2 | |||||
0 | 1.6 | 96.1 | |||||
low density lipoprotein cholesterol measurement | 2 | 94.2 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | solute carrier family 2 member 9 | VGNC:12986 | 465225 | |||||
Macaque | solute carrier family 2 member 9 | 712922 | ||||||
Mouse | MGI:2152844 | 117591 | ||||||
Rat | RGD:1597012 | 501925 | ||||||
Dog | solute carrier family 2 member 9 | VGNC:46345 | 479093 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | solute carrier family 2 member 9 | |||||
Macaque | solute carrier family 2 member 9 | |||||
Mouse | ||||||
Rat | ||||||
Dog | solute carrier family 2 member 9 | |||||
Publication Statistics
PubMed Score 170.30
PubMed score by year
PubTator Score 142.63
PubTator score by year
Related Publications
Text Mined References (143)
GeneRif Annotations (123)
Items per page:
0 of 0
PMID | Year | Title |
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