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Tbio
SLC2A9
Solute carrier family 2, facilitated glucose transporter member 9

Protein Summary
Description
Transport urate and fructose. May have a role in the urate reabsorption by proximal tubules. Also transports glucose at low rate. This gene encodes a member of the SLC2A facilitative glucose transporter family. Members of this family play a significant role in maintaining glucose homeostasis. The encoded protein may play a role in the development and survival of chondrocytes in cartilage matrices. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264784
  • ENSP00000264784
  • ENSG00000109667
  • ENST00000309065
  • ENSP00000311383
  • ENST00000506583
  • ENSP00000422209

Symbol
  • GLUT9
  • GLUT9
  • GLUTX
  • UAQTL2
  • URATv1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.74
disease
0.73
biological term
0.7
molecular function
0.7
phenotype
0.64


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 164.37   (req: < 5)
Gene RIFs: 123   (req: <= 3)
Antibodies: 264   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 164.37   (req: >= 5)
Gene RIFs: 123   (req: > 3)
Antibodies: 264   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (28)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
15
12
20
11.9
100
uric acid measurement
18
16
25
15.7
100
8
4
0
1.6
99
DNA methylation
1
1
1
96.1
high density lipoprotein cholesterol measurement
2
2
2
95.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
20
11.9
100
uric acid measurement
25
15.7
100
0
1.6
99
DNA methylation
1
96.1
high density lipoprotein cholesterol measurement
2
95.1
Pathways (26)
Cellular hexose transport (R-HSA-189200)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cellular hexose transport
Reactome
Defective SLC2A9 causes hypouricemia renal 2 (RHUC2)
Reactome
Disease
Reactome
Disorders of transmembrane transporters
Reactome
SLC transporter disorders
Name
Explore in Pharos
Explore in Source
Cellular hexose transport
Defective SLC2A9 causes hypouricemia renal 2 (RHUC2)
Disease
Disorders of transmembrane transporters
SLC transporter disorders
Protein-Protein Interactions (126)
1 – 10 of 126
ZNF136
Tdark
Family: TF
Novelty: 0.68698067
p_int: 0.999992725
p_ni: 8e-9
p_wrong: 0.000007267
Data Source: BioPlex
HIP1R
Tbio
Novelty: 0.02502713
p_int: 0.998275075
p_ni: 0.001724923
p_wrong: 2e-9
Data Source: BioPlex
ZWILCH
Tbio
Novelty: 0.05184569
p_int: 0.997919223
p_ni: 0.002029387
p_wrong: 0.000051391
Data Source: BioPlex
ECPAS
Tbio
Novelty: 0.04004664
p_int: 0.995858201
p_ni: 0.004141799
Data Source: BioPlex
SLC25A46
Tbio
Family: Transporter
Novelty: 0.02720146
p_int: 0.987983251
p_ni: 0.012016736
p_wrong: 1.3e-8
Data Source: BioPlex
COG1
Tbio
Novelty: 0.0124285
p_int: 0.980366386
p_ni: 0.019633614
p_wrong: 1e-9
Data Source: BioPlex
STK17B
Tchem
Family: Kinase
Novelty: 0.0420158
p_int: 0.976688407
p_ni: 0.022939643
p_wrong: 0.00037195
Data Source: BioPlex
RAI2
Tdark
Novelty: 0.09286714
p_int: 0.96895135
p_ni: 7.44e-7
p_wrong: 0.031047905
Data Source: BioPlex
MTX3
Tdark
Novelty: 0.06082176
p_int: 0.961017058
p_ni: 0.038981801
p_wrong: 0.000001141
Data Source: BioPlex
INTS12
Tbio
Family: Epigenetic
Novelty: 0.09023473
p_int: 0.953989674
p_ni: 0.046010324
p_wrong: 2e-9
Data Source: BioPlex
Publication Statistics
PubMed Score  164.37

PubMed score by year
PubTator Score  142.63

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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