SLC2A9
Solute carrier family 2, facilitated glucose transporter member 9
Protein Classes
Protein Summary
Transport urate and fructose. May have a role in the urate reabsorption by proximal tubules. Also transports glucose at low rate. This gene encodes a member of the SLC2A facilitative glucose transporter family. Members of this family play a significant role in maintaining glucose homeostasis. The encoded protein may play a role in the development and survival of chondrocytes in cartilage matrices. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
- ENST00000264784
- ENSP00000264784
- ENSG00000109667
- ENST00000309065
- ENSP00000311383
- ENST00000506583
- ENSP00000422209
- GLUT9
- GLUT9
- GLUTX
- UAQTL2
- URATv1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
cell type or tissue | 0.74 | ||
disease | 0.73 | ||
biological term | 0.7 | ||
molecular function | 0.7 | ||
phenotype | 0.64 | ||
IDG Partner Tools
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 164.37 (req: < 5)
Gene RIFs: 123 (req: <= 3)
Antibodies: 264 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 164.37 (req: >= 5)
Gene RIFs: 123 (req: > 3)
Antibodies: 264 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
GWAS Traits (28)
Items per page:
1 – 5 of 28
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
urate measurement | 15 | 12 | 20 | 11.9 | 100 | ||||
uric acid measurement | 18 | 16 | 25 | 15.7 | 100 | ||||
8 | 4 | 0 | 1.6 | 99 | |||||
DNA methylation | 1 | 1 | 1 | 96.1 | |||||
high density lipoprotein cholesterol measurement | 2 | 2 | 2 | 95.1 | |||||
Items per page:
1 – 5 of 28
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
urate measurement | 20 | 11.9 | 100 | ||||
uric acid measurement | 25 | 15.7 | 100 | ||||
0 | 1.6 | 99 | |||||
DNA methylation | 1 | 96.1 | |||||
high density lipoprotein cholesterol measurement | 2 | 95.1 | |||||
Pathways (26)
Reactome (7)
WikiPathways (19)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 7
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cellular hexose transport | ||||
Reactome | Defective SLC2A9 causes hypouricemia renal 2 (RHUC2) | ||||
Reactome | Disease | ||||
Reactome | Disorders of transmembrane transporters | ||||
Reactome | SLC transporter disorders | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cellular hexose transport | ||||
Defective SLC2A9 causes hypouricemia renal 2 (RHUC2) | ||||
Disease | ||||
Disorders of transmembrane transporters | ||||
SLC transporter disorders | ||||
Gene Ontology Terms (11)
Functions (4)
Components (4)
Processes (3)
Items per page:
10
1 – 4 of 4
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Traceable Author Statement (TAS) | Reactome | |||
Non-traceable Author Statement (NAS) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Protein-Protein Interactions (126)
1 – 10 of 126
ZNF136
Family: TF
Novelty: 0.68698067
p_int: 0.999992725
p_ni: 8e-9
p_wrong: 0.000007267
Data Source: BioPlex
HIP1R
Novelty: 0.02502713
p_int: 0.998275075
p_ni: 0.001724923
p_wrong: 2e-9
Data Source: BioPlex
ZWILCH
Novelty: 0.05184569
p_int: 0.997919223
p_ni: 0.002029387
p_wrong: 0.000051391
Data Source: BioPlex
ECPAS
Novelty: 0.04004664
p_int: 0.995858201
p_ni: 0.004141799
Data Source: BioPlex
SLC25A46
Family: Transporter
Novelty: 0.02720146
p_int: 0.987983251
p_ni: 0.012016736
p_wrong: 1.3e-8
Data Source: BioPlex
COG1
Novelty: 0.0124285
p_int: 0.980366386
p_ni: 0.019633614
p_wrong: 1e-9
Data Source: BioPlex
STK17B
Family: Kinase
Novelty: 0.0420158
p_int: 0.976688407
p_ni: 0.022939643
p_wrong: 0.00037195
Data Source: BioPlex
RAI2
Novelty: 0.09286714
p_int: 0.96895135
p_ni: 7.44e-7
p_wrong: 0.031047905
Data Source: BioPlex
MTX3
Novelty: 0.06082176
p_int: 0.961017058
p_ni: 0.038981801
p_wrong: 0.000001141
Data Source: BioPlex
INTS12
Family: Epigenetic
Novelty: 0.09023473
p_int: 0.953989674
p_ni: 0.046010324
p_wrong: 2e-9
Data Source: BioPlex
Publication Statistics
PubMed Score 164.37
PubMed score by year
PubTator Score 142.63
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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UniProt Keyword
GWAS Trait