Tbio SLC2A9 Solute carrier family 2, facilitated glucose transporter member 9

Protein Classes

DTO Classes

Protein / Transporter / Slc Superfamily Of Solute Carriers / Slc2 Family Of Hexose And Sugar Alcohol Transporters / Class Ii Transporters / Solute Carrier Family 2, Facilitated Glucose Transporter Member 9

Protein Summary

Description

Transport urate and fructose. May have a role in the urate reabsorption by proximal tubules. Also transports glucose at low rate. This gene encodes a member of the SLC2A facilitative glucose transporter family. Members of this family play a significant role in maintaining glucose homeostasis. The encoded protein may play a role in the development and survival of chondrocytes in cartilage matrices. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9NRM0
• Q0VGC4
• Q4W5D1
• Q8WV30
• Q96P00

Gene Name

• SLC2A9

Ensembl ID

• ENST00000264784
• ENSP00000264784
• ENSG00000109667
• ENST00000309065
• ENSP00000311383
• ENST00000506583
• ENSP00000422209

Symbol

• GLUT9
• GLUT9
• GLUTX
• UAQTL2
• URATv1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.74
disease	0.73
biological term	0.7
molecular function	0.7
phenotype	0.64

Related Tools

RESOLUTE

RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.

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Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 170.3   (req: < 5)

Gene RIFs: 123   (req: <= 3)

Antibodies: 264   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 170.3   (req: >= 5)

Gene RIFs: 123   (req: > 3)

Antibodies: 264   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

GWAS Traits (29)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 29

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
urate measurement	EFO_0004531	18	52	59	9.3	100
uric acid measurement	EFO_0004761	18	16	25	15.7	99.9
blood metabolite measurement	EFO_0005664	2	3	3		97.2
gout	EFO_0004274	8	4	0	1.6	96.1
high density lipoprotein cholesterol measurement	EFO_0004612	2	2	2		94.2

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 29

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
urate measurement	EFO_0004531	59	9.3	100
uric acid measurement	EFO_0004761	25	15.7	99.9
blood metabolite measurement	EFO_0005664	3		97.2
gout	EFO_0004274	0	1.6	96.1
high density lipoprotein cholesterol measurement	EFO_0004612	2		94.2

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Orthologs (11)

1 – 5 of 11

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	solute carrier family 2 member 9	VGNC:12986	465225
Macaque	solute carrier family 2 member 9		712922
Mouse	solute carrier family 2 (facilitated glucose transporter), member 9	MGI:2152844	117591
Rat	solute carrier family 2 member 9	RGD:1597012	501925
Dog	solute carrier family 2 member 9	VGNC:46345	479093

Species	Name	OMA	EggNOG	Inparanoid
Chimp	solute carrier family 2 member 9
Macaque	solute carrier family 2 member 9
Mouse	solute carrier family 2 (facilitated glucose transporter), member 9
Rat	solute carrier family 2 member 9
Dog	solute carrier family 2 member 9

Protein Structure (0 Structures, 1 AlphaFold Model)

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Representation

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Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

AF-Q9NRM0-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (26)

Reactome (7)

WikiPathways (19)

Cellular hexose transport (R-HSA-189200)

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Find Similar Targets

Items per page:

5

1 – 5 of 7

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Cellular hexose transport	21 targets	R-HSA-189200
Reactome	Defective SLC2A9 causes hypouricemia renal 2 (RHUC2)	1 targets	R-HSA-5619047
Reactome	Disease	1105 targets	R-HSA-1643685
Reactome	Disorders of transmembrane transporters	178 targets	R-HSA-5619115
Reactome	SLC transporter disorders	100 targets	R-HSA-5619102

Name	Explore in Pharos	Explore in Source
Cellular hexose transport	21 targets	R-HSA-189200
Defective SLC2A9 causes hypouricemia renal 2 (RHUC2)	1 targets	R-HSA-5619047
Disease	1105 targets	R-HSA-1643685
Disorders of transmembrane transporters	178 targets	R-HSA-5619115
SLC transporter disorders	100 targets	R-HSA-5619102

Gene Ontology Terms (11)

Functions (4)

Components (4)

Processes (3)

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Items per page:

10

1 – 4 of 4

GO Term	Evidence	Assigned by
urate transmembrane transporter activity	Inferred from Direct Assay (IDA)	UniProtKB
transmembrane transporter activity	Traceable Author Statement (TAS)	Reactome
carbohydrate:proton symporter activity	Non-traceable Author Statement (NAS)	UniProtKB
glucose transmembrane transporter activity	Inferred from Electronic Annotation (IEA)	Ensembl

Protein-Protein Interactions (126)

Explore Interacting Targets

1 – 10 of 126

• See Interactions on String-DB

ZNF136

Tdark

Family:  TF

Novelty:  0.68698067

p_int:  0.999992725

p_ni:  8e-9

p_wrong:  0.000007267

Data Source:  BioPlex

HIP1R

Tbio

Novelty:  0.02502713

p_int:  0.998275075

p_ni:  0.001724923

p_wrong:  2e-9

Data Source:  BioPlex

ZWILCH

Tbio

Novelty:  0.05184569

p_int:  0.997919223

p_ni:  0.002029387

p_wrong:  0.000051391

Data Source:  BioPlex

ECPAS

Tbio

Novelty:  0.04004664

p_int:  0.995858201

p_ni:  0.004141799

Data Source:  BioPlex

SLC25A46

Tbio

Family:  Transporter

Novelty:  0.02720146

p_int:  0.987983251

p_ni:  0.012016736

p_wrong:  1.3e-8

Data Source:  BioPlex

COG1

Tbio

Novelty:  0.0124285

p_int:  0.980366386

p_ni:  0.019633614

p_wrong:  1e-9

Data Source:  BioPlex

STK17B

Tchem

Family:  Kinase

Novelty:  0.0420158

p_int:  0.976688407

p_ni:  0.022939643

p_wrong:  0.00037195

Data Source:  BioPlex

RAI2

Tdark

Novelty:  0.09286714

p_int:  0.96895135

p_ni:  7.44e-7

p_wrong:  0.031047905

Data Source:  BioPlex

MTX3

Tdark

Novelty:  0.06082176

p_int:  0.961017058

p_ni:  0.038981801

p_wrong:  0.000001141

Data Source:  BioPlex

INTS12

Tbio

Family:  Epigenetic

Novelty:  0.09023473

p_int:  0.953989674

p_ni:  0.046010324

p_wrong:  2e-9

Data Source:  BioPlex

Publication Statistics

PubMed Score  170.30

PubMed score by year

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PubTator Score  142.63

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Cell membrane
Complete proteome
Disease mutation
Glycoprotein
Membrane
Phosphoprotein
Polymorphism
Reference proteome
Sugar transport

GWAS Trait Find Similar Targets

No Header	No Header
aspartate aminotransferase measurement
atrial fibrillation
basophil count
blood metabolite measurement
butyrylcholinesterase measurement
C-reactive protein measurement
creatinine measurement
DNA methylation
excessive daytime sleepiness measurement
ferritin measurement

MGI Phenotype Find Similar Targets

No Header	No Header
adipose tissue phenotype
behavior/neurological phenotype
cardiovascular system phenotype
digestive/alimentary phenotype
growth/size/body region phenotype
homeostasis/metabolism phenotype
immune system phenotype
liver/biliary system phenotype
mortality/aging
renal/urinary system phenotype