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Tbio
CCL28
C-C motif chemokine 28

Protein Summary
Description
Chemotactic activity for resting CD4, CD8 T-cells and eosinophils. Binds to CCR3 and CCR10 and induces calcium mobilization in a dose-dependent manner. This antimicrobial gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for resting CD4 or CD8 T cells and eosinophils. The product of this gene binds to chemokine receptors CCR3 and CCR10. This chemokine may play a role in the physiology of extracutaneous epithelial tissues, including diverse mucosal organs. Multiple transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Sep 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361115
  • ENSP00000354416
  • ENSG00000151882
  • ENST00000489442
  • ENSP00000426424

Symbol
  • SCYA28
  • MEC
  • CCK1
  • SCYA28
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.64
gene perturbation
0.59
biological process
0.56
PubMedID
0.5
metabolite
0.45


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 156.23   (req: < 5)
Gene RIFs: 23   (req: <= 3)
Antibodies: 309   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 156.23   (req: >= 5)
Gene RIFs: 23   (req: > 3)
Antibodies: 309   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
1
1
1
16.6
reticulocyte measurement
2
1
2
3.3
reticulocyte count
1
1
1
3.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
1
16.6
reticulocyte measurement
2
3.3
reticulocyte count
1
3.2
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
C-C motif chemokine ligand 28
574221
Mouse
MGI:1861731
56838
Rat
RGD:619937
114492
Dog
C-C motif chemokine ligand 28
VGNC:38890
448795
Horse
C-C motif chemokine ligand 28 [Source:HGNC Symbol;Acc:HGNC:17700]
Species
Name
OMA
EggNOG
Inparanoid
Macaque
C-C motif chemokine ligand 28
Mouse
Rat
Dog
C-C motif chemokine ligand 28
Horse
C-C motif chemokine ligand 28 [Source:HGNC Symbol;Acc:HGNC:17700]
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9NRJ3-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (127)
Chemokine receptors bind chemokines (R-HSA-380108)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chemokine receptors bind chemokines
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Name
Explore in Pharos
Explore in Source
Chemokine receptors bind chemokines
Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
GPCR downstream signalling
GPCR ligand binding
Gene Ontology Terms (16)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (243)
1 – 10 of 243
CCR10
Tchem
Family: GPCR
Novelty: 0.014331
Score: 0.975
Data Source: Reactome,STRINGDB
CCR9
Tchem
Family: GPCR
Novelty: 0.00654663
Score: 0.963
Data Source: STRINGDB
CXCR5
Tbio
Family: GPCR
Novelty: 0.00214886
Score: 0.959
Data Source: STRINGDB
PYY
Tbio
Novelty: 0.00060997
Score: 0.953
Data Source: STRINGDB
CCR3
Tchem
Family: GPCR
Novelty: 0.00197059
Score: 0.951
Data Source: STRINGDB
NPY
Tbio
Novelty: 0.00012637
Score: 0.947
Data Source: STRINGDB
CCL25
Tbio
Novelty: 0.00824289
Score: 0.941
Data Source: STRINGDB
CNR1
Tclin
Family: GPCR
Novelty: 0.00060063
Score: 0.94
Data Source: STRINGDB
CXCL13
Tbio
Novelty: 0.00118688
Score: 0.939
Data Source: STRINGDB
CCK
Tbio
Novelty: 0.00012268
Score: 0.938
Data Source: STRINGDB
Publication Statistics
PubMed Score  156.23

PubMed score by year
PubTator Score  400.81

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer