CCL28
C-C motif chemokine 28
Protein Summary
Chemotactic activity for resting CD4, CD8 T-cells and eosinophils. Binds to CCR3 and CCR10 and induces calcium mobilization in a dose-dependent manner. This antimicrobial gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for resting CD4 or CD8 T cells and eosinophils. The product of this gene binds to chemokine receptors CCR3 and CCR10. This chemokine may play a role in the physiology of extracutaneous epithelial tissues, including diverse mucosal organs. Multiple transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Sep 2014]
- ENST00000361115
- ENSP00000354416
- ENSG00000151882
- ENST00000489442
- ENSP00000426424
- SCYA28
- MEC
- CCK1
- SCYA28
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
tissue sample | 0.64 | ||
gene perturbation | 0.59 | ||
biological process | 0.56 | ||
PubMedID | 0.5 | ||
metabolite | 0.45 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 158.46 (req: < 5)
Gene RIFs: 23 (req: <= 3)
Antibodies: 309 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 158.46 (req: >= 5)
Gene RIFs: 23 (req: > 3)
Antibodies: 309 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 12
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (243)
Nearest Tclin Targets (3)
Downstream (3)
1 – 3 of 3
Pathways (127)
Reactome (8)
KEGG (4)
WikiPathways (115)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Chemokine receptors bind chemokines | ||||
Reactome | Class A/1 (Rhodopsin-like receptors) | ||||
Reactome | G alpha (i) signalling events | ||||
Reactome | GPCR downstream signalling | ||||
Reactome | GPCR ligand binding | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Chemokine receptors bind chemokines | ||||
Class A/1 (Rhodopsin-like receptors) | ||||
G alpha (i) signalling events | ||||
GPCR downstream signalling | ||||
GPCR ligand binding | ||||
Viral Interactions (0)
Gene Ontology Terms (16)
Functions (1)
Components (4)
Processes (11)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Disease Associations ()
GWAS Traits (7)
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
mathematical ability | 4 | 3 | 4 | 69.6 | |||||
lymphocyte count | 1 | 1 | 1 | 57.3 | |||||
leukocyte count | 1 | 1 | 1 | 35 | |||||
self reported educational attainment | 1 | 1 | 1 | 33.1 | |||||
red blood cell distribution width | 1 | 1 | 1 | 15.8 | |||||
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
mathematical ability | 4 | 69.6 | |||||
lymphocyte count | 1 | 57.3 | |||||
leukocyte count | 1 | 35 | |||||
self reported educational attainment | 1 | 33.1 | |||||
red blood cell distribution width | 1 | 15.8 | |||||
Find similar targets by:
IDG Resources
Orthologs (7)
1 – 5 of 7
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | C-C motif chemokine ligand 28 | 574221 | ||||||
Mouse | MGI:1861731 | 56838 | ||||||
Rat | RGD:619937 | 114492 | ||||||
Dog | C-C motif chemokine ligand 28 | VGNC:38890 | 448795 | |||||
Horse | C-C motif chemokine ligand 28 [Source:HGNC Symbol;Acc:HGNC:17700] | |||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Macaque | C-C motif chemokine ligand 28 | |||||
Mouse | ||||||
Rat | ||||||
Dog | C-C motif chemokine ligand 28 | |||||
Horse | C-C motif chemokine ligand 28 [Source:HGNC Symbol;Acc:HGNC:17700] | |||||
Publication Statistics
PubMed Score 158.46
PubMed score by year
PubTator Score 400.81
PubTator score by year
Related Publications
Text Mined References (43)
GeneRif Annotations (23)
Items per page:
0 of 0
PMID | Year | Title |
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