CCL28
C-C motif chemokine 28
Protein Summary
Chemotactic activity for resting CD4, CD8 T-cells and eosinophils. Binds to CCR3 and CCR10 and induces calcium mobilization in a dose-dependent manner. This antimicrobial gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for resting CD4 or CD8 T cells and eosinophils. The product of this gene binds to chemokine receptors CCR3 and CCR10. This chemokine may play a role in the physiology of extracutaneous epithelial tissues, including diverse mucosal organs. Multiple transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Sep 2014]
- ENST00000361115
- ENSP00000354416
- ENSG00000151882
- ENST00000489442
- ENSP00000426424
- SCYA28
- MEC
- CCK1
- SCYA28
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
tissue sample | 0.64 | ||
gene perturbation | 0.59 | ||
biological process | 0.56 | ||
PubMedID | 0.5 | ||
metabolite | 0.45 | ||
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 156.23 (req: < 5)
Gene RIFs: 23 (req: <= 3)
Antibodies: 309 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 156.23 (req: >= 5)
Gene RIFs: 23 (req: > 3)
Antibodies: 309 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 12
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
GWAS Traits (3)
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1 – 3 of 3
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
red blood cell distribution width | 1 | 1 | 1 | 16.6 | |||||
reticulocyte measurement | 2 | 1 | 2 | 3.3 | |||||
reticulocyte count | 1 | 1 | 1 | 3.2 | |||||
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
red blood cell distribution width | 1 | 16.6 | |||||
reticulocyte measurement | 2 | 3.3 | |||||
reticulocyte count | 1 | 3.2 | |||||
Orthologs (7)
1 – 5 of 7
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | C-C motif chemokine ligand 28 | 574221 | ||||||
Mouse | MGI:1861731 | 56838 | ||||||
Rat | RGD:619937 | 114492 | ||||||
Dog | C-C motif chemokine ligand 28 | VGNC:38890 | 448795 | |||||
Horse | C-C motif chemokine ligand 28 [Source:HGNC Symbol;Acc:HGNC:17700] | |||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Macaque | C-C motif chemokine ligand 28 | |||||
Mouse | ||||||
Rat | ||||||
Dog | C-C motif chemokine ligand 28 | |||||
Horse | C-C motif chemokine ligand 28 [Source:HGNC Symbol;Acc:HGNC:17700] | |||||
Protein Structure (1 Structure, 1 AlphaFold Model)
Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB
1 – 1 of 1
PDB Structure Id | Ligand | Method | Resolution (Å) | Residues | Fraction of Total Protein | Pub Year | Title |
|---|
PDB Structure Id | Fraction of Total Protein | Resolution | Pub Year |
|---|
Pathways (127)
Reactome (8)
KEGG (4)
WikiPathways (115)
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Items per page:
1 – 5 of 8
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Chemokine receptors bind chemokines | ||||
Reactome | Class A/1 (Rhodopsin-like receptors) | ||||
Reactome | G alpha (i) signalling events | ||||
Reactome | GPCR downstream signalling | ||||
Reactome | GPCR ligand binding | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Chemokine receptors bind chemokines | ||||
Class A/1 (Rhodopsin-like receptors) | ||||
G alpha (i) signalling events | ||||
GPCR downstream signalling | ||||
GPCR ligand binding | ||||
Gene Ontology Terms (16)
Functions (1)
Components (4)
Processes (11)
Items per page:
10
1 – 1 of 1
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Protein-Protein Interactions (243)
1 – 10 of 243
CCR10
Family: GPCR
Novelty: 0.014331
Score: 0.975
Data Source: Reactome,STRINGDB
CCR9
Family: GPCR
Novelty: 0.00654663
Score: 0.963
Data Source: STRINGDB
CXCR5
Family: GPCR
Novelty: 0.00214886
Score: 0.959
Data Source: STRINGDB
PYY
Novelty: 0.00060997
Score: 0.953
Data Source: STRINGDB
CCR3
Family: GPCR
Novelty: 0.00197059
Score: 0.951
Data Source: STRINGDB
NPY
Novelty: 0.00012637
Score: 0.947
Data Source: STRINGDB
CCL25
Novelty: 0.00824289
Score: 0.941
Data Source: STRINGDB
CNR1
Family: GPCR
Novelty: 0.00060063
Score: 0.94
Data Source: STRINGDB
CXCL13
Novelty: 0.00118688
Score: 0.939
Data Source: STRINGDB
CCK
Novelty: 0.00012268
Score: 0.938
Data Source: STRINGDB
Publication Statistics
PubMed Score 156.23
PubMed score by year
PubTator Score 400.81
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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