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Tbio
AAAS
Aladin

Protein Summary
Description
Plays a role in the normal development of the peripheral and central nervous system. The protein encoded by this gene is a member of the WD-repeat family of regulatory proteins and may be involved in normal development of the peripheral and central nervous system. The encoded protein is part of the nuclear pore complex and is anchored there by NDC1. Defects in this gene are a cause of achalasia-addisonianism-alacrima syndrome (AAAS), also called triple-A syndrome or Allgrove syndrome. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000209873
  • ENSP00000209873
  • ENSG00000094914
  • ENST00000394384
  • ENSP00000377908

Symbol
  • ADRACALA
  • AAA
  • AAASb
  • GL003
  • ALADIN
  • ADRACALA
  • ADRACALIN
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
pathway
0.99
transcription factor binding site profile
0.95
cellular component
0.75
biological process
0.74
small molecule perturbation
0.65


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 122.23   (req: < 5)
View Publications
Gene RIFs: 32   (req: <= 3)
View Gene RIFs
Antibodies: 221   (req: <= 50)
View Antibodies
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 122.23   (req: >= 5)
Gene RIFs: 32   (req: > 3)
Antibodies: 221   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
View GO Terms
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
aladin WD repeat nucleoporin
VGNC:8311
467003
Mouse
achalasia, adrenocortical insufficiency, alacrimia
MGI:2443767
223921
Rat
aladin WD repeat nucleoporin
RGD:1308701
300259
Dog
aladin WD repeat nucleoporin
VGNC:37402
607867
Horse
aladin WD repeat nucleoporin
VGNC:14884
100063811
Species
Name
OMA
EggNOG
Inparanoid
Chimp
aladin WD repeat nucleoporin
Mouse
achalasia, adrenocortical insufficiency, alacrimia
Rat
aladin WD repeat nucleoporin
Dog
aladin WD repeat nucleoporin
Horse
aladin WD repeat nucleoporin
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9NRG9-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (69)
Antiviral mechanism by IFN-stimulated genes (R-HSA-1169410)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 68
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Antiviral mechanism by IFN-stimulated genes
82 targets
R-HSA-1169410
Reactome
Cell Cycle
597 targets
R-HSA-1640170
Reactome
Cell Cycle, Mitotic
495 targets
R-HSA-69278
Reactome
Cellular response to heat stress
100 targets
R-HSA-3371556
Reactome
Cellular responses to external stimuli
487 targets
R-HSA-8953897
Name
Explore in Pharos
Explore in Source
Antiviral mechanism by IFN-stimulated genes
82 targets
R-HSA-1169410
Cell Cycle
597 targets
R-HSA-1640170
Cell Cycle, Mitotic
495 targets
R-HSA-69278
Cellular response to heat stress
100 targets
R-HSA-3371556
Cellular responses to external stimuli
487 targets
R-HSA-8953897
Gene Ontology Terms (14)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
centrosome
Inferred from Direct Assay (IDA)
HPA
cytosol
Inferred from Direct Assay (IDA)
HPA
nuclear membrane
Inferred from Direct Assay (IDA)
HPA
nuclear pore
Inferred from Direct Assay (IDA)
UniProtKB
nucleoplasm
Inferred from Direct Assay (IDA)
HPA
membrane
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
nucleus
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
nuclear envelope
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (180)
1 – 10 of 180
NUP35
Tbio
Novelty: 0.0355102
p_int: 0.999953001
p_ni: 0.000046999
Score: 0.955
Data Source: BioPlex,STRINGDB
NDC1
Tbio
Novelty: 0.15840853
p_int: 0.998686988
p_ni: 0.001312843
p_wrong: 1.69e-7
Score: 0.957
Data Source: BioPlex,STRINGDB
LOR
Tbio
Novelty: 0.0033781
p_int: 0.983774221
p_ni: 0.016224842
p_wrong: 9.37e-7
Data Source: BioPlex
TMEM9
Tbio
Novelty: 0.06916197
p_int: 0.94234316
p_ni: 0.05765684
Data Source: BioPlex
JTB
Tbio
Novelty: 0.06646216
p_int: 0.898666059
p_ni: 0.101333941
Data Source: BioPlex
NUP107
Tbio
Novelty: 0.01994155
Score: 0.987
Data Source: STRINGDB
NUP43
Tbio
Novelty: 0.11571309
Score: 0.981
Data Source: STRINGDB
NUP37
Tbio
Novelty: 0.1270421
Score: 0.975
Data Source: STRINGDB
NUP155
Tbio
Novelty: 0.03884486
Score: 0.973
Data Source: STRINGDB
NUP153
Tbio
Novelty: 0.00696568
Score: 0.971
Data Source: STRINGDB
Publication Statistics
PubMed Score  122.23

PubMed score by year
PubTator Score  153.65

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer