Protein Summary
Plays a role in the normal development of the peripheral and central nervous system. The protein encoded by this gene is a member of the WD-repeat family of regulatory proteins and may be involved in normal development of the peripheral and central nervous system. The encoded protein is part of the nuclear pore complex and is anchored there by NDC1. Defects in this gene are a cause of achalasia-addisonianism-alacrima syndrome (AAAS), also called triple-A syndrome or Allgrove syndrome. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]
- ENST00000209873
- ENSP00000209873
- ENSG00000094914
- ENST00000394384
- ENSP00000377908
- ADRACALA
- AAA
- AAASb
- GL003
- ALADIN
- ADRACALA
- ADRACALIN
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
pathway | 0.99 | ||
transcription factor binding site profile | 0.95 | ||
cellular component | 0.75 | ||
biological process | 0.74 | ||
small molecule perturbation | 0.65 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 128.53 (req: < 5)
Gene RIFs: 32 (req: <= 3)
Antibodies: 221 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 128.53 (req: >= 5)
Gene RIFs: 32 (req: > 3)
Antibodies: 221 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Pathways (69)
Reactome (68)
KEGG (1)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 68
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Antiviral mechanism by IFN-stimulated genes | ||||
Reactome | Cell Cycle | ||||
Reactome | Cell Cycle, Mitotic | ||||
Reactome | Cellular response to heat stress | ||||
Reactome | Cellular responses to external stimuli | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Antiviral mechanism by IFN-stimulated genes | ||||
Cell Cycle | ||||
Cell Cycle, Mitotic | ||||
Cellular response to heat stress | ||||
Cellular responses to external stimuli | ||||
Gene Ontology Terms (14)
Components (8)
Processes (6)
Items per page:
10
1 – 8 of 8
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | HPA | |||
Inferred from Direct Assay (IDA) | HPA | |||
Inferred from Direct Assay (IDA) | HPA | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | HPA | |||
Inferred from High Throughput Direct Assay (HDA) | UniProtKB | |||
Inferred from High Throughput Direct Assay (HDA) | UniProtKB | |||
Traceable Author Statement (TAS) | Reactome | |||
Protein-Protein Interactions (180)
1 – 10 of 180
NUP35
Novelty: 0.04732031
p_int: 0.999953001
p_ni: 0.000046999
Score: 0.955
Data Source: BioPlex,STRINGDB
NDC1
Novelty: 0.16348774
p_int: 0.998686988
p_ni: 0.001312843
p_wrong: 1.69e-7
Score: 0.957
Data Source: BioPlex,STRINGDB
LOR
Novelty: 0.00458013
p_int: 0.983774221
p_ni: 0.016224842
p_wrong: 9.37e-7
Data Source: BioPlex
TMEM9
Novelty: 0.1192335
p_int: 0.94234316
p_ni: 0.05765684
Data Source: BioPlex
JTB
Novelty: 0.0209205
p_int: 0.898666059
p_ni: 0.101333941
Data Source: BioPlex
NUP107
Novelty: 0.03049877
Score: 0.987
Data Source: STRINGDB
NUP43
Novelty: 0.35294118
Score: 0.981
Data Source: STRINGDB
NUP37
Novelty: 0.20162717
Score: 0.975
Data Source: STRINGDB
NUP155
Novelty: 0.06122928
Score: 0.973
Data Source: STRINGDB
NUP153
Novelty: 0.00678043
Score: 0.971
Data Source: STRINGDB
Publication Statistics
PubMed Score 128.53
PubMed score by year
PubTator Score 153.65
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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