Tbio PRTFDC1 Phosphoribosyltransferase domain-containing protein 1

Protein Summary

Description

Has low, barely detectable phosphoribosyltransferase activity (in vitro). Binds GMP, IMP and alpha-D-5-phosphoribosyl 1-pyrophosphate (PRPP). Is not expected to contribute to purine metabolism or GMP salvage.

Uniprot Accession IDs

• Q9NRG1
• B7Z1Z3
• Q53HA7
• Q59EL9
• Q5VV18
• Q5VV20

Gene Name

• PRTFDC1

Ensembl ID

• ENST00000320152
• ENSP00000318602
• ENSG00000099256
• ENST00000376376
• ENSP00000365556
• ENST00000376378
• ENSP00000365558

Symbol

• HHGP
• HHGP

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.83
histone modification site profile	0.72
molecular function	0.7
tissue sample	0.69
cell type or tissue	0.67

Protein Classes

PANTHER Classes

Protein / Transferase / Glycosyltransferase / Phosphoribosyltransferase Domain-containing Protein 1

Protein / Isomerase / Mutase / Phosphoribosyltransferase Domain-containing Protein 1

DTO Classes

Protein / Enzyme / Isomerase / Mutase / Phosphoribosyltransferase Domain-containing Protein 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.91   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 209   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.91   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 209   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0