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Tbio
POLE3
DNA polymerase epsilon subunit 3

Protein Summary
Description
Forms a complex with DNA polymerase epsilon subunit CHRAC1 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome-remodeling activity of ISWI/SNF2H and ACF1. POLE3 is a histone-fold protein that interacts with other histone-fold proteins to bind DNA in a sequence-independent manner. These histone-fold protein dimers combine within larger enzymatic complexes for DNA transcription, replication, and packaging.[supplied by OMIM, Apr 2004]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000374169
  • ENSP00000363284
  • ENSG00000148229
  • ENST00000374171
  • ENSP00000363286

Symbol
  • CHRAC17
  • p17
  • YBL1
  • CHRAC2
  • CHRAC17
  • CHARAC17
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.97
kinase perturbation
0.91
histone modification site profile
0.89
transcription factor binding site profile
0.88
transcription factor perturbation
0.88


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.85   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 195   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.85   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 195   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood lead measurement
1
2
2
72.4
hematocrit
1
1
1
71.2
reticulocyte measurement
2
1
2
62.1
reticulocyte count
2
1
2
60.5
leukocyte count
1
1
1
48.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood lead measurement
2
72.4
hematocrit
1
71.2
reticulocyte measurement
2
62.1
reticulocyte count
2
60.5
leukocyte count
1
48.5
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
DNA polymerase epsilon 3, accessory subunit
VGNC:13945
741748
Mouse
MGI:1933378
59001
Dog
DNA polymerase epsilon 3, accessory subunit
VGNC:44780
612550
Cow
DNA polymerase epsilon 3, accessory subunit
VGNC:33120
510678
Pig
DNA polymerase epsilon 3, accessory subunit
100517450
Species
Name
OMA
EggNOG
Inparanoid
Chimp
DNA polymerase epsilon 3, accessory subunit
Mouse
Dog
DNA polymerase epsilon 3, accessory subunit
Cow
DNA polymerase epsilon 3, accessory subunit
Pig
DNA polymerase epsilon 3, accessory subunit
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9NRF9-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (39)
Activation of the pre-replicative complex (R-HSA-68962)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 35
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of the pre-replicative complex
Reactome
Base Excision Repair
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Chromosome Maintenance
Name
Explore in Pharos
Explore in Source
Activation of the pre-replicative complex
Base Excision Repair
Cell Cycle
Cell Cycle, Mitotic
Chromosome Maintenance
Protein-Protein Interactions (237)
1 – 10 of 237
BAZ1A
Tbio
Family:  Epigenetic
Novelty:  0.01833837
p_int:  0.999999809
p_ni:  1.91e-7
p_wrong:  1e-9
Score:  0.91
Data Source:  BioPlex,STRINGDB
GDAP2
Tbio
Novelty:  0.09960735
p_int:  0.999994759
p_ni:  0.000004799
p_wrong:  4.42e-7
Data Source:  BioPlex
CHRAC1
Tbio
Novelty:  0.17492099
p_int:  0.999949477
p_ni:  0.000050173
p_wrong:  3.5e-7
Score:  0.999
Data Source:  BioPlex,STRINGDB
POLE4
Tdark
Family:  Enzyme
Novelty:  0.23346084
p_int:  0.999931776
p_ni:  0.000066728
p_wrong:  0.000001497
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
RAP1A
Tchem
Family:  Enzyme
Novelty:  0.00375413
p_int:  0.999871412
p_ni:  0.000128429
p_wrong:  1.59e-7
Score:  0.156
Data Source:  BioPlex,STRINGDB
POLE
Tclin
Family:  Enzyme
Novelty:  0.00371129
p_int:  0.999817296
p_ni:  0.000182704
Score:  0.998
Data Source:  BioPlex,Reactome,STRINGDB
SMARCA1
Tbio
Novelty:  0.00452148
p_int:  0.999578883
p_ni:  0.000421117
Score:  0.845
Data Source:  BioPlex,STRINGDB
PNMA8A
Tdark
Novelty:  0.95674878
p_int:  0.997753729
p_ni:  0.002246234
p_wrong:  3.6e-8
Data Source:  BioPlex
DRAP1
Tbio
Novelty:  0.05872031
p_int:  0.994629965
p_ni:  0.005364738
p_wrong:  0.000005298
Score:  0.533
Data Source:  BioPlex,STRINGDB
POLE2
Tbio
Family:  Enzyme
Novelty:  0.03129531
p_int:  0.993770641
p_ni:  0.006229359
p_wrong:  1e-9
Score:  0.997
Data Source:  BioPlex,Reactome,STRINGDB
Publication Statistics
PubMed Score  11.85

PubMed score by year
PubTator Score  19.59

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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