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Tbio
CTPS2
CTP synthase 2

Protein Summary
Description
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Constitutes the rate-limiting enzyme in the synthesis of cytosine nucleotides. The protein encoded by this gene catalyzes the formation of CTP from UTP with the concomitant deamination of glutamine to glutamate. This protein is the rate-limiting enzyme in the synthesis of cytosine nucleotides, which play an important role in various metabolic processes and provide the precursors necessary for the synthesis of RNA and DNA. Cancer cells that exhibit increased cell proliferation also exhibit an increased activity of this encoded protein. Thus, this protein is an attractive target for selective chemotherapy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000359276
  • ENSP00000352222
  • ENSG00000047230
  • ENST00000380241
  • ENSP00000369590
  • ENST00000443824
  • ENSP00000401264
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.91
molecular function
0.86
disease perturbation
0.83
protein domain
0.73
kinase perturbation
0.66


Related Tools
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ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.99   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 187   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.99   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 187   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
CTP synthase 2
VGNC:1396
107971131
Macaque
CTP synthase 2
721014
Mouse
MGI:1933185
55936
Rat
RGD:1563369
619580
Dog
CTP synthase 2
VGNC:39705
480851
Species
Name
OMA
EggNOG
Inparanoid
Chimp
CTP synthase 2
Macaque
CTP synthase 2
Mouse
Rat
Dog
CTP synthase 2
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9NRF8-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (11)
Interconversion of nucleotide di- and triphosphates (R-HSA-499943)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Interconversion of nucleotide di- and triphosphates
Reactome
Metabolism
Reactome
Metabolism of nucleotides
Name
Explore in Pharos
Explore in Source
Interconversion of nucleotide di- and triphosphates
Metabolism
Metabolism of nucleotides
Gene Ontology Terms (12)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (215)
1 – 10 of 215
TIGD3
Tdark
Novelty: 1.23642174
p_int: 0.999973164
p_ni: 0.000026836
Score: 0.933
Data Source: BioPlex,STRINGDB
CTPS1
Tbio
Family: Enzyme
Novelty: 0.00911596
p_int: 0.999039139
p_ni: 0.000960859
p_wrong: 3e-9
Score: 0.988
Data Source: BioPlex,STRINGDB
SUGP1
Tbio
Novelty: 0.00434166
p_int: 0.961447148
p_ni: 0.038552852
Score: 0.345
Data Source: BioPlex,STRINGDB
POLR1B
Tbio
Family: Enzyme
Novelty: 0.06955307
Score: 0.944
Data Source: STRINGDB
GMPS
Tbio
Family: Enzyme
Novelty: 0.00611806
Score: 0.926
Data Source: STRINGDB
NME1
Tbio
Family: Kinase
Novelty: 0.00103216
Score: 0.916
Data Source: STRINGDB
NME4
Tbio
Family: Kinase
Novelty: 0.03735196
Score: 0.912
Data Source: STRINGDB
NME7
Tbio
Family: Enzyme
Novelty: 0.08546782
Score: 0.91
Data Source: STRINGDB
NME3
Tbio
Family: Kinase
Novelty: 0.05947052
Score: 0.91
Data Source: STRINGDB
NME6
Tbio
Family: Kinase
Novelty: 0.12087274
Score: 0.91
Data Source: STRINGDB
Publication Statistics
PubMed Score  14.99

PubMed score by year
PubTator Score  4.92

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer