You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
SH2B1
SH2B adapter protein 1

Protein Summary
Description
Adapter protein for several members of the tyrosine kinase receptor family. Involved in multiple signaling pathways mediated by Janus kinase (JAK) and receptor tyrosine kinases, including the receptors of insulin (INS), insulin-like growth factor I (IGF1), nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF), platelet-derived growth factor (PDGF) and fibroblast growth factors (FGFs). In growth hormone (GH) signaling, autophosphorylated ('Tyr-813') JAK2 recruits SH2B1, which in turn is phosphorylated by JAK2 on tyrosine residues. These phosphotyrosines form potential binding sites for other signaling proteins. GH also promotes serine/threonine phosphorylation of SH2B1 and these phosphorylated residues may serve to recruit other proteins to the GHR-JAK2-SH2B1 complexes, such as RAC1. In leptin (LEP) signaling, binds to and potentiates the activation of JAK2 by globally enhancing downstream pathways. In response to leptin, ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000322610
  • ENSP00000321221
  • ENSG00000178188
  • ENST00000337120
  • ENSP00000337163
  • ENST00000359285
  • ENSP00000352232
  • ENST00000395532
  • ENSP00000378903
  • ENST00000618521
  • ENSP00000481709

Symbol
  • KIAA1299
  • SH2B
  • PSM
  • SH2B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
histone modification site profile
0.92
transcription factor binding site profile
0.86
transcription factor
0.84
disease perturbation
0.79


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 73.24   (req: < 5)
Gene RIFs: 41   (req: <= 3)
Antibodies: 268   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 73.24   (req: >= 5)
Gene RIFs: 41   (req: > 3)
Antibodies: 268   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (99)
CCDC102B
Tdark
Novelty:  0.28075569
p_int:  0.976596836
p_ni:  4.9e-8
p_wrong:  0.023403115
Score:  0.219
Data Source:  BioPlex,STRINGDB
JAK2
Tclin
Family:  Kinase
Novelty:  0.00022894
Score:  0.975
Data Source:  Reactome,STRINGDB
IRS1
Tchem
Novelty:  0.00048281
Score:  0.913
Data Source:  Reactome,STRINGDB
NTRK1
Tclin
Family:  Kinase
Novelty:  0.00033453
Score:  0.896
Data Source:  STRINGDB
NTRK2
Tclin
Family:  Kinase
Novelty:  0.00054534
Score:  0.894
Data Source:  STRINGDB
GRB2
Tchem
Novelty:  0.00091605
Score:  0.892
Data Source:  STRINGDB
SH2B3
Tbio
Novelty:  0.00509422
Score:  0.866
Data Source:  STRINGDB
KCTD15
Tbio
Novelty:  0.05277304
Score:  0.862
Data Source:  STRINGDB
TMEM18
Tbio
Novelty:  0.02382811
Score:  0.838
Data Source:  STRINGDB
GNPDA2
Tbio
Family:  Enzyme
Novelty:  0.02712908
Score:  0.837
Data Source:  STRINGDB
Pathways (14)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Factors involved in megakaryocyte development and platelet production
Reactome
Growth hormone receptor signaling
Reactome
Hemostasis
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Factors involved in megakaryocyte development and platelet production
Growth hormone receptor signaling
Hemostasis
Immune System
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (43)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
17
8
30
3.6
98.6
intelligence
8
13
6
6.8
94.1
cognitive function measurement
3
3
4
92.2
mathematical ability
3
2
3
91.4
grip strength measurement
2
2
2
88.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
30
3.6
98.6
intelligence
6
6.8
94.1
cognitive function measurement
4
92.2
mathematical ability
3
91.4
grip strength measurement
2
88.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SH2B adaptor protein 1
VGNC:13769
738177
Macaque
SH2B adaptor protein 1
708160
Mouse
MGI:1201407
20399
Rat
RGD:620132
89817
Dog
SH2B adaptor protein 1
VGNC:46109
612792
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SH2B adaptor protein 1
Macaque
SH2B adaptor protein 1
Mouse
Rat
Dog
SH2B adaptor protein 1
Publication Statistics
PubMed Score 73.24
PubMed score by year
PubTator Score 58.92
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title