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Tbio
TSHZ2
Teashirt homolog 2

Protein Summary
Description
Probable transcriptional regulator involved in developmental processes. May act as a transcriptional repressor (Potential). This gene is a member of the teashirt C2H2-type zinc-finger protein family of transcription factors. This gene encodes a protein with five C2H2-type zinc fingers, a homeobox DNA-binding domain and a coiled-coil domain. This nuclear protein is predicted to act as a transcriptional repressor. This gene is thought to play a role in the development and progression of breast and other types of cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000329613
  • ENSP00000333114
  • ENSG00000182463
  • ENST00000371497
  • ENSP00000360552
  • ENST00000603338
  • ENSP00000475114

Symbol
  • C20orf17
  • TSH2
  • ZNF218
  • TSH2
  • ZABC2
  • ZNF218
  • OVC10-2
  • C20orf17
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
1
transcription factor perturbation
0.8
microRNA
0.78
transcription factor
0.77
protein domain
0.73


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.28   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 110   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.28   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 110   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (22)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
waist-hip ratio
3
8
8
94.3
BMI-adjusted waist-hip ratio
3
7
8
94
waist circumference
1
2
2
80.6
BMI-adjusted waist circumference
1
2
2
79.2
lymphocyte count
2
2
2
72.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
waist-hip ratio
8
94.3
BMI-adjusted waist-hip ratio
8
94
waist circumference
2
80.6
BMI-adjusted waist circumference
2
79.2
lymphocyte count
2
72.8
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
teashirt zinc finger homeobox 2
VGNC:14144
458344
Macaque
teashirt zinc finger homeobox 2
709155
Mouse
MGI:2153084
228911
Rat
Dog
teashirt zinc finger homeobox 2
VGNC:47904
106557707
Species
Name
OMA
EggNOG
Inparanoid
Chimp
teashirt zinc finger homeobox 2
Macaque
teashirt zinc finger homeobox 2
Mouse
Rat
Dog
teashirt zinc finger homeobox 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9NRE2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (8)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (39)
1 – 10 of 39
BCAS4
Tbio
Novelty:  0.11759439
Score:  0.683
Data Source:  STRINGDB
ZNF217
Tbio
Family:  TF
Novelty:  0.01313576
Score:  0.644
Data Source:  STRINGDB
ZFP64
Tbio
Family:  TF
Novelty:  0.15985218
Score:  0.609
Data Source:  STRINGDB
ZFP64
Tbio
Novelty:  0.15985218
Score:  0.609
Data Source:  STRINGDB
MEIS2
Tbio
Family:  TF
Novelty:  0.01393828
Score:  0.603
Data Source:  STRINGDB
MEIS1
Tbio
Family:  TF
Novelty:  0.00480433
Score:  0.603
Data Source:  STRINGDB
ADAP1
Tbio
Novelty:  0.03287486
Score:  0.592
Data Source:  STRINGDB
ZIC4
Tbio
Family:  TF
Novelty:  0.02855743
Score:  0.557
Data Source:  STRINGDB
ZNF503
Tbio
Novelty:  0.07234099
Score:  0.555
Data Source:  STRINGDB
PARM1
Tbio
Novelty:  0.06590176
Score:  0.536
Data Source:  STRINGDB
Publication Statistics
PubMed Score  7.28

PubMed score by year
PubTator Score  2.57

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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