Tbio DUOX1 Dual oxidase 1

Protein Summary

Description

Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain. The protein encoded by this gene is a glycoprotein and a member of the NADPH oxidase family. The synthesis of thyroid hormone is catalyzed by a protein complex located at the apical membrane of thyroid follicular cells. This complex contains an iodide transporter, thyroperoxidase, and a peroxide generating system that includes proteins encoded by this gene and the similar DUOX2 gene. This protein is known as dual oxidase because it has both a peroxidase homology domain and a gp91phox domain. This protein generates hydrogen peroxide and thereby plays a role in the activity of thyroid peroxidase, lactoperoxidase, and in lactoperoxidase-mediated antimicrobial defense at mucosal surfaces. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2012]

Uniprot Accession IDs

• Q9NRD9
• A6NH28
• Q14C94
• Q6ZMB3
• Q6ZR09
• Q9NZC1

Gene Name

• DUOX1

Ensembl ID

• ENST00000321429
• ENSP00000317997
• ENSG00000137857
• ENST00000389037
• ENSP00000373689
• ENST00000561166
• ENSP00000454065

Symbol

• DUOX
• LNOX1
• THOX1
• LNOX1
• THOX1
• NOXEF1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	1
molecular function	0.81
cell type or tissue	0.74
virus perturbation	0.72
tissue sample	0.66

Protein Classes

PANTHER Classes

Protein / Oxidoreductase / Oxidase / Dual Oxidase 1

DTO Classes

Protein / Enzyme / Oxidoreductase / Oxidase / Dual Oxidase 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 571.37   (req: < 5)

Gene RIFs: 57   (req: <= 3)

Antibodies: 112   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 571.37   (req: >= 5)

Gene RIFs: 57   (req: > 3)

Antibodies: 112   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0