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Tchem
DUOX2
Dual oxidase 2

Protein Summary
Description
Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain. The protein encoded by this gene is a glycoprotein and a member of the NADPH oxidase family. The synthesis of thyroid hormone is catalyzed by a protein complex located at the apical membrane of thyroid follicular cells. This complex contains an iodide transporter, thyroperoxidase, and a peroxide generating system that includes this encoded protein and DUOX1. This protein is known as dual oxidase because it has both a peroxidase homology domain and a gp91phox domain. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000603300
  • ENSP00000475084
  • ENSG00000140279

Symbol
  • LNOX2
  • THOX2
  • TDH6
  • LNOX2
  • THOX2
  • NOXEF2
  • P138-TOX
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
cell type or tissue
0.74
biological term
0.69
cell line
0.65
molecular function
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 396.21   (req: < 5)
Gene RIFs: 84   (req: <= 3)
Antibodies: 159   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 396.21   (req: >= 5)
Gene RIFs: 84   (req: > 3)
Antibodies: 159   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (57)
DUOXA2
Tbio
Family:  Enzyme
Novelty:  0.02873436
Score:  0.994
Data Source:  STRINGDB
DUOXA1
Tbio
Family:  Enzyme
Novelty:  0.04733549
Score:  0.944
Data Source:  STRINGDB
DECR1
Tbio
Family:  Enzyme
Novelty:  0.02699187
Score:  0.896
Data Source:  STRINGDB
NCF1
Tbio
Novelty:  0.00120288
Score:  0.824
Data Source:  STRINGDB
CYBA
Tbio
Novelty:  0.00177762
Score:  0.744
Data Source:  STRINGDB
NCF2
Tbio
Novelty:  0.00274685
Score:  0.731
Data Source:  STRINGDB
IYD
Tbio
Family:  Enzyme
Novelty:  0.02255665
Score:  0.714
Data Source:  STRINGDB
SLC28A2
Tchem
Family:  Transporter
Novelty:  0.00967399
Score:  0.71
Data Source:  STRINGDB
CAT
Tbio
Family:  Enzyme
Novelty:  0.00181888
Score:  0.702
Data Source:  STRINGDB
DMBT1
Tbio
Novelty:  0.00357297
Score:  0.693
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of amine-derived hormones
Reactome
Metabolism of amino acids and derivatives
Reactome
Thyroxine biosynthesis
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of amine-derived hormones
Metabolism of amino acids and derivatives
Thyroxine biosynthesis
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
creatinine measurement
1
5
5
93.1
glomerular filtration rate
1
5
5
92.9
ferritin measurement
1
1
1
87.4
total iron binding capacity
1
1
1
71.3
transferrin saturation measurement
1
1
1
52.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
creatinine measurement
5
93.1
glomerular filtration rate
5
92.9
ferritin measurement
1
87.4
total iron binding capacity
1
71.3
transferrin saturation measurement
1
52.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
dual oxidase 2
VGNC:2483
453395
Macaque
dual oxidase 2
713906
Mouse
MGI:3036280
214593
Rat
RGD:628761
79107
Dog
dual oxidase 2
VGNC:40121
403719
Species
Name
OMA
EggNOG
Inparanoid
Chimp
dual oxidase 2
Macaque
dual oxidase 2
Mouse
Rat
Dog
dual oxidase 2
Publication Statistics
PubMed Score 396.21
PubMed score by year
PubTator Score 186.79
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title