Protein Summary
Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain. The protein encoded by this gene is a glycoprotein and a member of the NADPH oxidase family. The synthesis of thyroid hormone is catalyzed by a protein complex located at the apical membrane of thyroid follicular cells. This complex contains an iodide transporter, thyroperoxidase, and a peroxide generating system that includes this encoded protein and DUOX1. This protein is known as dual oxidase because it has both a peroxidase homology domain and a gp91phox domain. [provided by RefSeq, Jul 2008]
- ENST00000603300
- ENSP00000475084
- ENSG00000140279
- LNOX2
- THOX2
- TDH6
- LNOX2
- THOX2
- NOXEF2
- P138-TOX
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 1 | ||
cell type or tissue | 0.74 | ||
biological term | 0.69 | ||
cell line | 0.65 | ||
molecular function | 0.63 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 396.21 (req: < 5)
Gene RIFs: 84 (req: <= 3)
Antibodies: 159 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 396.21 (req: >= 5)
Gene RIFs: 84 (req: > 3)
Antibodies: 159 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 20
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 1
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (1)
Protein-Protein Interactions (57)
Nearest Tclin Targets
Pathways (7)
Reactome (4)
KEGG (1)
UniProt (1)
WikiPathways (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Metabolism | ||||
Reactome | Metabolism of amine-derived hormones | ||||
Reactome | Metabolism of amino acids and derivatives | ||||
Reactome | Thyroxine biosynthesis | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Metabolism | ||||
Metabolism of amine-derived hormones | ||||
Metabolism of amino acids and derivatives | ||||
Thyroxine biosynthesis | ||||
Viral Interactions (0)
Gene Ontology Terms (25)
Functions (4)
Components (5)
Processes (16)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations (null)
GWAS Traits (6)
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
creatinine measurement | 1 | 5 | 5 | 93.1 | |||||
glomerular filtration rate | 1 | 5 | 5 | 92.9 | |||||
ferritin measurement | 1 | 1 | 1 | 87.4 | |||||
total iron binding capacity | 1 | 1 | 1 | 71.3 | |||||
transferrin saturation measurement | 1 | 1 | 1 | 52.4 | |||||
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
creatinine measurement | 5 | 93.1 | |||||
glomerular filtration rate | 5 | 92.9 | |||||
ferritin measurement | 1 | 87.4 | |||||
total iron binding capacity | 1 | 71.3 | |||||
transferrin saturation measurement | 1 | 52.4 | |||||
Find similar targets by:
IDG Resources
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | dual oxidase 2 | VGNC:2483 | 453395 | |||||
Macaque | dual oxidase 2 | 713906 | ||||||
Mouse | MGI:3036280 | 214593 | ||||||
Rat | RGD:628761 | 79107 | ||||||
Dog | dual oxidase 2 | VGNC:40121 | 403719 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | dual oxidase 2 | |||||
Macaque | dual oxidase 2 | |||||
Mouse | ||||||
Rat | ||||||
Dog | dual oxidase 2 | |||||
Publication Statistics
PubMed Score 396.21
PubMed score by year
PubTator Score 186.79
PubTator score by year
Related Publications
Text Mined References (103)
GeneRif Annotations (84)
Items per page:
0 of 0
PMID | Year | Title |
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