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Tbio
PICK1
PRKCA-binding protein

Protein Summary
Description
Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competetive with nucleation promoting factors and is linked to neuronal morphology regulation and AMPA receptor (AMPAR) endocytosis. Via interaction with the Arp2/3 complex involved in regulation of synaptic plasicity of excitatory synapses and required for spine shrinkage during long-term depression (LTD). Involved in regulation of astrocyte morphology, antagonistic to Arp2/3 complex activator WASL/N-WASP function. The protein encoded by t ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000356976
  • ENSP00000349465
  • ENSG00000100151
  • ENST00000404072
  • ENSP00000385205

Symbol
  • PRKCABP
  • PICK
  • PRKCABP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.92
histone modification site profile
0.91
molecular function
0.9
viral protein
0.8
disease perturbation
0.79


Related Tools
GENEVA
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GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 204.31   (req: < 5)
Gene RIFs: 32   (req: <= 3)
Antibodies: 413   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 204.31   (req: >= 5)
Gene RIFs: 32   (req: > 3)
Antibodies: 413   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 28
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protein interacting with PRKCA 1
VGNC:5295
470270
Macaque
protein interacting with PRKCA 1
699815
Mouse
MGI:894645
18693
Rat
RGD:69437
84591
Dog
protein interacting with PRKCA 1
VGNC:44525
610191
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protein interacting with PRKCA 1
Macaque
protein interacting with PRKCA 1
Mouse
Rat
Dog
protein interacting with PRKCA 1
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9NRD5-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (16)
Cell surface interactions at the vascular wall (R-HSA-202733)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell surface interactions at the vascular wall
Reactome
Glutamate binding, activation of AMPA receptors and synaptic plasticity
Reactome
Hemostasis
Reactome
Neuronal System
Reactome
Neurotransmitter receptors and postsynaptic signal transmission
Name
Explore in Pharos
Explore in Source
Cell surface interactions at the vascular wall
Glutamate binding, activation of AMPA receptors and synaptic plasticity
Hemostasis
Neuronal System
Neurotransmitter receptors and postsynaptic signal transmission
Gene Ontology Terms (46)
Items per page:
10
1 – 10 of 11
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
ParkinsonsUK-UCL
Inferred from Sequence or structural Similarity (ISS)
ParkinsonsUK-UCL
Inferred from Sequence or structural Similarity (ISS)
ParkinsonsUK-UCL
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (152)
1 – 10 of 152
ICA1
Tbio
Novelty: 0.01241573
p_int: 0.999999995
p_ni: 2e-9
p_wrong: 3e-9
Score: 0.859
Data Source: BioPlex,STRINGDB
PRXL2C
Tdark
Novelty: 0.59489208
p_int: 0.999999995
p_ni: 2e-9
p_wrong: 3e-9
Score: 0.209
Data Source: BioPlex,STRINGDB
CEP89
Tbio
Novelty: 0.17461805
p_int: 0.999999992
p_ni: 7e-9
Score: 0.209
Data Source: BioPlex,STRINGDB
ATP6AP2
Tbio
Novelty: 0.00357665
p_int: 0.999999987
p_ni: 1.3e-8
Score: 0.177
Data Source: BioPlex,STRINGDB
ICA1L
Tdark
Novelty: 0.69333512
p_int: 0.999999956
p_ni: 5e-9
p_wrong: 3.9e-8
Score: 0.812
Data Source: BioPlex,STRINGDB
MAGEA1
Tbio
Novelty: 0.00506874
p_int: 0.999998549
p_ni: 0.00000137
p_wrong: 8.2e-8
Data Source: BioPlex
RASSF7
Tbio
Novelty: 0.08011259
p_int: 0.999997264
p_ni: 0.000002726
p_wrong: 1e-8
Data Source: BioPlex
RNF181
Tbio
Family: Enzyme
Novelty: 0.27482636
p_int: 0.99999533
p_ni: 0.000004669
p_wrong: 1e-9
Data Source: BioPlex
UACA
Tbio
Novelty: 0.05853699
p_int: 0.999995054
p_ni: 0.000004929
p_wrong: 1.6e-8
Score: 0.241
Data Source: BioPlex,STRINGDB
KLHL11
Tbio
Novelty: 0.1537041
p_int: 0.999992611
p_ni: 0.000007389
Data Source: BioPlex
Publication Statistics
PubMed Score  204.31

PubMed score by year
PubTator Score  2320.41

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer