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Tbio
FBXO6
F-box only protein 6

Protein Summary
Description
Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes. Involved in endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Able to recognize and bind denatured glycoproteins, which are modified with not only high-mannose but also complex-type oligosaccharides. Also recognizes sulfated glycans. Also involved in DNA damage response by specifically recognizing activated CHEK1 (phosphorylated on 'Ser-345'), promoting its ubiquitination and degradation. Ubiquitination of CHEK1 is required to insure that activated CHEK1 does not accumulate as cells progress through S phase, or when replication forks encounter transient impediments during normal DNA replication. This gene encodes a member of the F-box protein family which is characterized ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000376753
  • ENSP00000365944
  • ENSG00000116663

Symbol
  • FBG2
  • FBS2
  • FBX6
  • FBG2
  • FBS2
  • FBX6
  • Fbx6b
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.8
transcription factor binding site profile
0.74
tissue sample
0.69
disease perturbation
0.68
transcription factor
0.61


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.24   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 189   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.24   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 189   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
F-box protein 6
VGNC:1240
469799
Mouse
MGI:1354743
50762
Rat
RGD:620418
192351
Dog
F-box protein 6
VGNC:40788
487444
Horse
F-box protein 6
VGNC:17960
100056376
Species
Name
OMA
EggNOG
Inparanoid
Chimp
F-box protein 6
Mouse
Rat
Dog
F-box protein 6
Horse
F-box protein 6
Pathways (12)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Association of TriC/CCT with target proteins during biosynthesis
Reactome
Chaperonin-mediated protein folding
Reactome
Class I MHC mediated antigen processing & presentation
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Association of TriC/CCT with target proteins during biosynthesis
Chaperonin-mediated protein folding
Class I MHC mediated antigen processing & presentation
Protein-Protein Interactions (373)
1 – 10 of 373
H6PD
Tbio
Novelty: 0.00366637
p_int: 0.999999946
p_ni: 5.1e-8
p_wrong: 3e-9
Score: 0.187
Data Source: BioPlex,STRINGDB
ENTPD5
Tbio
Family: Enzyme
Novelty: 0.01714402
p_int: 0.999846913
p_ni: 0.000045913
p_wrong: 0.000107175
Score: 0.187
Data Source: BioPlex,STRINGDB
ERO1B
Tbio
Novelty: 0.06389159
p_int: 0.999810089
p_ni: 0.000189911
Score: 0.29
Data Source: BioPlex,STRINGDB
MAN2B2
Tbio
Family: Enzyme
Novelty: 0.11499103
p_int: 0.99939198
p_ni: 0.000608019
Score: 0.169
Data Source: BioPlex,STRINGDB
UBB
Tbio
Novelty: 0.00661254
p_int: 0.999344275
p_ni: 0.000655725
Score: 0.908
Data Source: BioPlex,STRINGDB
GRN
Tbio
Novelty: 0.00096395
p_int: 0.999181819
p_ni: 0.00081818
Data Source: BioPlex
CUL1
Tbio
Novelty: 0.00244476
p_int: 0.998923168
p_ni: 0.001076832
Score: 0.972
Data Source: BioPlex,STRINGDB
TOR1B
Tbio
Novelty: 0.00611826
p_int: 0.997065533
p_ni: 0.002934467
Score: 0.181
Data Source: BioPlex,STRINGDB
NUDT9
Tbio
Family: Enzyme
Novelty: 0.0482661
p_int: 0.984904201
p_ni: 0.015094946
p_wrong: 8.54e-7
Score: 0.228
Data Source: BioPlex,STRINGDB
SGSH
Tbio
Family: Enzyme
Novelty: 0.00670111
p_int: 0.984609767
p_ni: 0.015390233
Score: 0.219
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  48.24

PubMed score by year
PubTator Score  32.87

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer