Tbio CHST12 Carbohydrate sulfotransferase 12

Protein Summary

Description

Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin and desulfated dermatan sulfate. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Activity toward partially desulfated dermatan sulfate is however lower. Does not form 4, 6-di-O-sulfated GalNAc when chondroitin sulfate C is used as an acceptor. The protein encoded by this gene belongs to the sulfotransferase 2 family. It is localized to the golgi membrane, and catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin and desulfated dermatan sulfate. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage, and is distributed on the surfaces of many cells and extracellular matrices. Alternatively spliced transcript variants differing only in their 5' UTRs have been found for this gene. [provided by RefSeq, Aug 2011]

Uniprot Accession IDs

• Q9NRB3
• A4D1Z9
• Q502W3
• Q9NXY7

Gene Name

• CHST12

Ensembl ID

• ENST00000258711
• ENSP00000258711
• ENSG00000136213
• ENST00000618655
• ENSP00000481912

Symbol

• C4S-2
• C4ST2
• C4ST-2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.88
kinase perturbation	0.76
transcription factor binding site profile	0.74
tissue sample	0.69
pathway	0.63

Protein Classes

PANTHER Classes

Protein / Transferase / Carbohydrate Sulfotransferase 12

DTO Classes

Protein / Enzyme / Transferase / Carbohydrate Sulfotransferase 12

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.83   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 61   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.83   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 61   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0