You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
PDGFC
Platelet-derived growth factor C

Protein Summary
Description
Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen and chemoattractant for cells of mesenchymal origin. Required for normal skeleton formation during embryonic development, especially for normal development of the craniofacial skeleton and for normal development of the palate. Required for normal skin morphogenesis during embryonic development. Plays an important role in wound healing, where it appears to be involved in three stages: inflammation, proliferation and remodeling. Plays an important role in angiogenesis and blood vessel development. Involved in fibrotic processes, in which transformation of interstitial fibroblasts into myofibroblasts plus collagen deposition occurs. The CUB domain has mitogenic activity in coronary artery smooth muscle cells, suggesting a role beyond the maintenance of the latency of the PDGF domain. In the nucleus, PDGFC seems to have additiona ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000422544
  • ENSP00000410048
  • ENSG00000145431
  • ENST00000502773
  • ENSP00000422464

Symbol
  • SCDGF
  • SCDGF
  • FALLOTEIN
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.99
transcription factor perturbation
0.96
gene perturbation
0.82
biological process
0.75
transcription factor binding site profile
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 157.05   (req: < 5)
Gene RIFs: 37   (req: <= 3)
Antibodies: 324   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 157.05   (req: >= 5)
Gene RIFs: 37   (req: > 3)
Antibodies: 324   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (65)
1 – 10 of 65
CREB3
Tbio
Family:  TF
Novelty:  0.00424318
p_int:  0.999962019
p_ni:  0.000019122
p_wrong:  0.000018859
Score:  0.412
Data Source:  BioPlex,STRINGDB
RLN1
Tbio
Novelty:  0.03992636
p_int:  0.999322546
p_ni:  0.000483512
p_wrong:  0.000193942
Data Source:  BioPlex
SCGB2A1
Tbio
Novelty:  0.01902973
p_int:  0.919225218
p_ni:  0.000443294
p_wrong:  0.080331488
Data Source:  BioPlex
PDGFRB
Tclin
Family:  Kinase
Novelty:  0.00074896
Score:  0.978
Data Source:  STRINGDB
PDGFRA
Tclin
Family:  Kinase
Novelty:  0.00066909
Score:  0.977
Data Source:  STRINGDB
PDGFA
Tchem
Novelty:  0.00155768
Score:  0.968
Data Source:  STRINGDB
PDGFB
Tbio
Novelty:  0.00080876
Score:  0.954
Data Source:  STRINGDB
EGF
Tbio
Novelty:  0.00010809
Score:  0.877
Data Source:  STRINGDB
FLT4
Tclin
Family:  Kinase
Novelty:  0.001296
Score:  0.866
Data Source:  STRINGDB
FLT1
Tclin
Family:  Kinase
Novelty:  0.00039648
Score:  0.866
Data Source:  STRINGDB
Pathways (20)
Signal Transduction (R-HSA-162582)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Signal Transduction
Reactome
Signaling by PDGF
Reactome
Signaling by Receptor Tyrosine Kinases
Name
Explore in Pharos
Explore in Source
Signal Transduction
Signaling by PDGF
Signaling by Receptor Tyrosine Kinases
GWAS Traits (18)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
6
3
6
88
platelet count
2
2
2
79.5
platelet crit
2
2
2
73.6
monocyte count
1
1
1
59.6
reticulocyte measurement
3
2
3
53.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
6
88
platelet count
2
79.5
platelet crit
2
73.6
monocyte count
1
59.6
reticulocyte measurement
3
53.6
Find similar targets by:
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
platelet derived growth factor C
VGNC:657
736477
Macaque
platelet derived growth factor C
700236
Mouse
MGI:1859631
54635
Rat
RGD:68410
79429
Dog
platelet derived growth factor C
VGNC:44370
482666
Species
Name
OMA
EggNOG
Inparanoid
Chimp
platelet derived growth factor C
Macaque
platelet derived growth factor C
Mouse
Rat
Dog
platelet derived growth factor C
Publication Statistics
PubMed Score 157.05
PubMed score by year
PubTator Score 76.88
PubTator score by year