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Tbio
PDGFC
Platelet-derived growth factor C

Protein Summary
Description
Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen and chemoattractant for cells of mesenchymal origin. Required for normal skeleton formation during embryonic development, especially for normal development of the craniofacial skeleton and for normal development of the palate. Required for normal skin morphogenesis during embryonic development. Plays an important role in wound healing, where it appears to be involved in three stages: inflammation, proliferation and remodeling. Plays an important role in angiogenesis and blood vessel development. Involved in fibrotic processes, in which transformation of interstitial fibroblasts into myofibroblasts plus collagen deposition occurs. The CUB domain has mitogenic activity in coronary artery smooth muscle cells, suggesting a role beyond the maintenance of the latency of the PDGF domain. In the nucleus, PDGFC seems to have additiona ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000422544
  • ENSP00000410048
  • ENSG00000145431
  • ENST00000502773
  • ENSP00000422464

Symbol
  • SCDGF
  • SCDGF
  • FALLOTEIN
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.99
transcription factor perturbation
0.96
gene perturbation
0.82
biological process
0.75
transcription factor binding site profile
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 126.51   (req: < 5)
Gene RIFs: 37   (req: <= 3)
Antibodies: 324   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 126.51   (req: >= 5)
Gene RIFs: 37   (req: > 3)
Antibodies: 324   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (20)
Signal Transduction (R-HSA-162582)

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Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Signal Transduction
Reactome
Signaling by PDGF
Reactome
Signaling by Receptor Tyrosine Kinases
Name
Explore in Pharos
Explore in Source
Signal Transduction
Signaling by PDGF
Signaling by Receptor Tyrosine Kinases
Protein-Protein Interactions (65)
1 – 10 of 65
CREB3
Tbio
Family: TF
Novelty: 0.00516251
p_int: 0.999962019
p_ni: 0.000019122
p_wrong: 0.000018859
Score: 0.412
Data Source: BioPlex,STRINGDB
RLN1
Tbio
Novelty: 0.05712331
p_int: 0.999322546
p_ni: 0.000483512
p_wrong: 0.000193942
Data Source: BioPlex
SCGB2A1
Tbio
Novelty: 0.00455624
p_int: 0.919225218
p_ni: 0.000443294
p_wrong: 0.080331488
Data Source: BioPlex
PDGFRB
Tclin
Family: Kinase
Novelty: 0.00115144
Score: 0.978
Data Source: STRINGDB
PDGFRA
Tclin
Family: Kinase
Novelty: 0.00103644
Score: 0.977
Data Source: STRINGDB
PDGFA
Tchem
Novelty: 0.00178595
Score: 0.968
Data Source: STRINGDB
PDGFB
Tchem
Novelty: 0.000542
Score: 0.954
Data Source: STRINGDB
EGF
Tbio
Novelty: 0.00015623
Score: 0.877
Data Source: STRINGDB
FLT4
Tclin
Family: Kinase
Novelty: 0.00175479
Score: 0.866
Data Source: STRINGDB
FLT1
Tclin
Family: Kinase
Novelty: 0.00037168
Score: 0.866
Data Source: STRINGDB
Publication Statistics
PubMed Score  126.51

PubMed score by year
PubTator Score  76.88

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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