Tchem SPHK2 Sphingosine kinase 2

Protein Summary

Description

Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro-dihydrosphingosine, D-erythro-sphingosine and L-threo-dihydrosphingosine. Binds phosphoinositides. This gene encodes one of two sphingosine kinase isozymes that catalyze the phosphorylation of sphingosine into sphingosine 1-phosphate. Sphingosine 1-phosphate mediates many cellular processes including migration, proliferation and apoptosis, and also plays a role in several types of cancer by promoting angiogenesis and tumorigenesis. The encoded protein may play a role in breast cancer proliferation and chemoresistance. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011]

Uniprot Accession IDs

• Q9NRA0
• A0T4C8
• B4DU87
• Q9BRN1
• Q9H0Q2
• Q9NWU7
• SK 2

Gene Name

• SPHK2

Ensembl ID

• ENST00000245222
• ENSP00000245222
• ENSG00000063176
• ENST00000598088
• ENSP00000469158
• ENST00000599748
• ENSP00000471205
• ENST00000600537
• ENSP00000470092

Symbol

• SK 2
• SK-2
• SPK 2
• SPK-2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.98
transcription factor binding site profile	0.95
transcription factor	0.82
transcription factor perturbation	0.74
kinase	0.71

Protein Classes

DTO Classes

Protein / Kinase / Non-protein Kinase / Lipid Kinase / Sphingosine Kinase 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 291   (req: < 5)

Gene RIFs: 82   (req: <= 3)

Antibodies: 399   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 291   (req: >= 5)

Gene RIFs: 82   (req: > 3)

Antibodies: 399   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 19

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0