Pharos: Illuminating the Druggable Genome

Tchem

Protein Summary

Description

Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung and peripheral blood leukocytes, and lies in close proximity to another family member, TLR7, on chromosome X. [provided by ...more

Uniprot Accession IDs

Gene Name

TLR8

Ensembl ID

ENST00000218032
ENSP00000218032
ENSG00000101916
ENST00000311912
ENSP00000312082

Symbol

CD288

Illumination Graph

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.79

protein domain	0.73

phenotype	0.7

tissue sample	0.62

biological term	0.61

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 677.4 (req: < 5)

View Publications

Gene RIFs: 157 (req: <= 3)

View Gene RIFs

Antibodies: 771 (req: <= 50)

View Antibodies

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 677.4 (req: >= 5)

Gene RIFs: 157 (req: > 3)

Antibodies: 771 (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 31

View GO Terms

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 108

Explore Active Ligands

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Active Ligands (108)

1 – 10 of 108

Protein Data Bank (24)

1 – 5 of 24

PDB Structure Id	Ligand	Method	Resolution (Å)	M.W. (kDa)	Pub Year	Title

PDB Structure Id	M.W.	Resolution	Pub Year

Pathways (26)

Reactome (9)

KEGG (1)

PathwayCommons (1)

WikiPathways (15)

Immune System (R-HSA-168256)

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Items per page:

1 – 5 of 9

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Immune System	2246 targets	R-HSA-168256

Reactome	Innate Immune System	1188 targets	R-HSA-168249

Reactome	MyD88 dependent cascade initiated on endosome	91 targets	R-HSA-975155

Reactome	TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling	10 targets	R-HSA-975110

Reactome	TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	90 targets	R-HSA-975138

Name	Explore in Pharos	Explore in Source
Immune System	2246 targets	R-HSA-168256

Innate Immune System	1188 targets	R-HSA-168249

MyD88 dependent cascade initiated on endosome	91 targets	R-HSA-975155

TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling	10 targets	R-HSA-975110

TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	90 targets	R-HSA-975138

Gene Ontology Terms (38)

Functions (9)

Components (7)

Processes (22)

Items per page:

1 – 9 of 9

GO Term	Evidence	Assigned by
DNA binding	Inferred from Direct Assay (IDA)	UniProtKB

double-stranded RNA binding	Inferred from Direct Assay (IDA)	UniProtKB

single-stranded RNA binding	Inferred from Direct Assay (IDA)	UniProtKB

identical protein binding	Inferred from Physical Interaction (IPI)	IntAct

signaling pattern recognition receptor activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

RNA binding	Traceable Author Statement (TAS)	UniProtKB

signaling receptor activity	Non-traceable Author Statement (NAS)	UniProtKB

drug binding	Inferred from Electronic Annotation (IEA)	Ensembl

transmembrane signaling receptor activity	Inferred from Electronic Annotation (IEA)	InterPro

Protein-Protein Interactions (401)

1 – 10 of 401

See Interactions on String-DB

MYD88

Tbio

Novelty: 0.00054413

Score: 0.993