You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
TLR8
Toll-like receptor 8

Protein Summary
Description
Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung and peripheral blood leukocytes, and lies in close proximity to another family member, TLR7, on chromosome X. [provided by ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000218032
  • ENSP00000218032
  • ENSG00000101916
  • ENST00000311912
  • ENSP00000312082

Symbol
  • CD288
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.79
protein domain
0.73
phenotype
0.7
tissue sample
0.62
biological term
0.61


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 389.84   (req: < 5)
Gene RIFs: 157   (req: <= 3)
Antibodies: 771   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 389.84   (req: >= 5)
Gene RIFs: 157   (req: > 3)
Antibodies: 771   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 31
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 108
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
toll like receptor 8
473522
Macaque
toll like receptor 8
574292
Mouse
MGI:2176887
170744
Rat
RGD:1590327
684440
Dog
toll like receptor 8
100684828
Species
Name
OMA
EggNOG
Inparanoid
Chimp
toll like receptor 8
Macaque
toll like receptor 8
Mouse
Rat
Dog
toll like receptor 8
Protein Structure (24 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9NR97-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 24
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (26)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
MyD88 dependent cascade initiated on endosome
Reactome
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
Reactome
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
MyD88 dependent cascade initiated on endosome
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
Gene Ontology Terms (38)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (401)
1 – 10 of 401
MYD88
Tbio
Novelty: 0.00037931
Score: 0.993
Data Source: Reactome,STRINGDB
UNC93B1
Tbio
Novelty: 0.01288921
Score: 0.987
Data Source: Reactome,STRINGDB
IRAK1
Tchem
Family: Kinase
Novelty: 0.00170873
Score: 0.974
Data Source: Reactome,STRINGDB
IRF7
Tbio
Family: TF
Novelty: 0.0021839
Score: 0.971
Data Source: Reactome,STRINGDB
TRAF6
Tbio
Novelty: 0.00109366
Score: 0.971
Data Source: Reactome,STRINGDB
IRAK4
Tchem
Family: Kinase
Novelty: 0.00344058
Score: 0.97
Data Source: Reactome,STRINGDB
IRAK2
Tbio
Family: Kinase
Novelty: 0.01496024
Score: 0.96
Data Source: Reactome,STRINGDB
TLR7
Tclin
Novelty: 0.00067036
Score: 0.956
Data Source: STRINGDB
HSP90B1
Tchem
Novelty: 0.00135881
Score: 0.947
Data Source: STRINGDB
CNPY3
Tbio
Novelty: 0.11473132
Score: 0.941
Data Source: STRINGDB
Publication Statistics
PubMed Score  389.84

PubMed score by year
PubTator Score  359.78

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer