Protein Summary
Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung and peripheral blood leukocytes, and lies in close proximity to another family member, TLR7, on chromosome X. [provided by ...more
- ENST00000218032
- ENSP00000218032
- ENSG00000101916
- ENST00000311912
- ENSP00000312082
- CD288
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 0.79 | ||
protein domain | 0.73 | ||
phenotype | 0.7 | ||
tissue sample | 0.62 | ||
biological term | 0.61 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 547.27 (req: < 5)
Gene RIFs: 157 (req: <= 3)
Antibodies: 771 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 547.27 (req: >= 5)
Gene RIFs: 157 (req: > 3)
Antibodies: 771 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 31
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 215
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (215)
Protein-Protein Interactions (401)
Nearest Tclin Targets (2)
Downstream (2)
1 – 2 of 2
Pathways (26)
Reactome (9)
KEGG (1)
PathwayCommons (1)
WikiPathways (15)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Immune System | ||||
Reactome | Innate Immune System | ||||
Reactome | MyD88 dependent cascade initiated on endosome | ||||
Reactome | TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling | ||||
Reactome | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Immune System | ||||
Innate Immune System | ||||
MyD88 dependent cascade initiated on endosome | ||||
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling | ||||
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | ||||
Viral Interactions (0)
Gene Ontology Terms (38)
Functions (9)
Components (7)
Processes (22)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Traceable Author Statement (TAS) | UniProtKB | |||
Non-traceable Author Statement (NAS) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations (null)
GWAS Traits (4)
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
childhood onset asthma | 1 | 1 | 0 | 1 | 14.8 | ||||
asthma | 1 | 1 | 0 | 1 | 11.1 | ||||
monocyte count | 1 | 1 | 1 | 1.7 | |||||
C-reactive protein measurement | 1 | 1 | 1 | 1 | |||||
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
childhood onset asthma | 0 | 1 | 14.8 | ||||
asthma | 0 | 1 | 11.1 | ||||
monocyte count | 1 | 1.7 | |||||
C-reactive protein measurement | 1 | 1 | |||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | toll like receptor 8 | 473522 | ||||||
Macaque | toll like receptor 8 | 574292 | ||||||
Mouse | MGI:2176887 | 170744 | ||||||
Rat | RGD:1590327 | 684440 | ||||||
Dog | toll like receptor 8 | 100684828 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | toll like receptor 8 | |||||
Macaque | toll like receptor 8 | |||||
Mouse | ||||||
Rat | ||||||
Dog | toll like receptor 8 | |||||
Publication Statistics
PubMed Score 547.27
PubMed score by year
PubTator Score 359.78
PubTator score by year
Related Publications
Text Mined References (195)
GeneRif Annotations (157)
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0 of 0
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