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Tclin
TLR9
Toll-like receptor 9

Protein Summary
Description
Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (PubMed:11564765, PubMed:17932028). Controls lymphocyte response to Helicobacter infection (By similarity). Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production (PubMed:23857366). The protein encoded by this gene is a member of the Toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed ...more
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
1
cellular component
0.99
disease
0.82
phenotype
0.82


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1747.4   (req: < 5)
Gene RIFs: 577   (req: <= 3)
Antibodies: 971   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1747.4   (req: >= 5)
Gene RIFs: 577   (req: > 3)
Antibodies: 971   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 56
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 93
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
hydroxychloroquine
Rendered image for hydroxychloroquine
GWAS Traits (19)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist circumference
2
5
6
87.7
triglyceride measurement
2
3
3
86.7
waist-hip ratio
2
3
4
84.2
BMI-adjusted waist-hip ratio
3
3
4
83.2
waist circumference
1
3
3
78.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist circumference
6
87.7
triglyceride measurement
3
86.7
waist-hip ratio
4
84.2
BMI-adjusted waist-hip ratio
4
83.2
waist circumference
3
78.7
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1932389
81897
Cow
toll like receptor 9
282602
Pig
toll like receptor 9
397007
Zebrafish
ZDB-GENE-040219-10
403128
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Cow
toll like receptor 9
Pig
toll like receptor 9
Zebrafish
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9NR96-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (256)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 22
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
FLT3 Signaling
Reactome
IGF1R signaling cascade
Reactome
IRS-mediated signalling
Reactome
IRS-related events triggered by IGF1R
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
FLT3 Signaling
IGF1R signaling cascade
IRS-mediated signalling
IRS-related events triggered by IGF1R
Gene Ontology Terms (70)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (244)
1 – 10 of 244
MYD88
Tbio
Novelty:  0.00037931
Score:  0.993
Data Source:  Reactome,STRINGDB
IL10
Tbio
Novelty:  0.00004352
Score:  0.883
Data Source:  STRINGDB
IL6
Tclin
Novelty:  0.00001819
Score:  0.876
Data Source:  STRINGDB
CD40
Tchem
Novelty:  0.0002836
Score:  0.855
Data Source:  STRINGDB
UNC93B1
Tbio
Novelty:  0.01288921
Score:  0.836
Data Source:  Reactome,STRINGDB
TLR7
Tclin
Novelty:  0.00067036
Score:  0.835
Data Source:  Reactome,STRINGDB
CAMP
Tbio
Novelty:  0.00064433
Score:  0.833
Data Source:  STRINGDB
TNF
Tclin
Novelty:  0.00001457
Score:  0.798
Data Source:  STRINGDB
CXCL8
Tchem
Novelty:  0.00005958
Score:  0.794
Data Source:  STRINGDB
FOXP3
Tbio
Family:  TF
Novelty:  0.00017205
Score:  0.793
Data Source:  STRINGDB
Publication Statistics
PubMed Score  1747.40

PubMed score by year
PubTator Score  1581.06

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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