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Tclin
TLR9
Toll-like receptor 9

Protein Summary
Description
Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (PubMed:11564765, PubMed:17932028). Controls lymphocyte response to Helicobacter infection (By similarity). Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production (PubMed:23857366). The protein encoded by this gene is a member of the Toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed ...more
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
1
cellular component
0.99
disease
0.82
phenotype
0.82


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1188.02   (req: < 5)
Gene RIFs: 577   (req: <= 3)
Antibodies: 971   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1188.02   (req: >= 5)
Gene RIFs: 577   (req: > 3)
Antibodies: 971   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 56
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 40
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
hydroxychloroquine
chemical structure image
Pathways (256)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 22
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
FLT3 Signaling
Reactome
IGF1R signaling cascade
Reactome
IRS-mediated signalling
Reactome
IRS-related events triggered by IGF1R
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
FLT3 Signaling
IGF1R signaling cascade
IRS-mediated signalling
IRS-related events triggered by IGF1R
Gene Ontology Terms (70)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (244)
1 – 10 of 244
MYD88
Tbio
Novelty: 0.00054413
Score: 0.993
Data Source: Reactome,STRINGDB
IL10
Tbio
Novelty: 0.00007359
Score: 0.883
Data Source: STRINGDB
IL6
Tclin
Novelty: 0.00002829
Score: 0.876
Data Source: STRINGDB
CD40
Tchem
Novelty: 0.0003399
Score: 0.855
Data Source: STRINGDB
UNC93B1
Tbio
Novelty: 0.01966959
Score: 0.836
Data Source: Reactome,STRINGDB
TLR7
Tclin
Novelty: 0.00059474
Score: 0.835
Data Source: Reactome,STRINGDB
CAMP
Tbio
Novelty: 0.00089449
Score: 0.833
Data Source: STRINGDB
TNF
Tclin
Novelty: 0.00001974
Score: 0.798
Data Source: STRINGDB
CXCL8
Tchem
Novelty: 0.00009183
Score: 0.794
Data Source: STRINGDB
FOXP3
Tbio
Family: TF
Novelty: 0.00020363
Score: 0.793
Data Source: STRINGDB
Publication Statistics
PubMed Score  1188.02

PubMed score by year
PubTator Score  1581.06

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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