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Tclin
KCNQ5
Potassium voltage-gated channel subfamily KQT member 5

Protein Summary
Description
Associates with KCNQ3 to form a potassium channel which contributes to M-type current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons. Therefore, it is important in the regulation of neuronal excitability. May contribute, with other potassium channels, to the molecular diversity of a heterogeneous population of M-channels, varying in kinetic and pharmacological properties, which underlie this physiologically important current. Insensitive to tetraethylammonium, but inhibited by barium, linopirdine and XE991. Activated by niflumic acid and the anticonvulsant retigabine. As the native M-channel, the potassium channel composed of KCNQ3 and KCNQ5 is also suppressed by activation of the muscarinic acetylcholine receptor CHRM1. This gene is a member of the KCNQ potassium channel gene family that is differentially expressed in subregions of the brain and in skeletal muscle. The protein e ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000342056
  • ENSP00000345055
  • ENSG00000185760
  • ENST00000370392
  • ENSP00000359419
  • ENST00000370398
  • ENSP00000359425
  • ENST00000628967
  • ENSP00000486187
  • ENST00000629977
  • ENSP00000485743

Symbol
  • Kv7.5
  • MRD46
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.86
histone modification site profile
0.84
gene perturbation
0.76
microRNA
0.75
protein domain
0.73


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 76.84   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 224   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 76.84   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 224   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 9
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 5
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
refractive error measurement
2
3
3
82.9
FEV/FEC ratio
1
1
1
80.1
pulse pressure measurement
1
1
1
73.9
body mass index
2
2
2
70.4
peak expiratory flow
1
1
1
50.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
refractive error measurement
3
82.9
FEV/FEC ratio
1
80.1
pulse pressure measurement
1
73.9
body mass index
2
70.4
peak expiratory flow
1
50.6
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
potassium voltage-gated channel subfamily Q member 5
VGNC:11100
462817
Macaque
potassium voltage-gated channel subfamily Q member 5
715426
Mouse
MGI:1924937
226922
Rat
RGD:628848
259273
Dog
potassium voltage-gated channel subfamily Q member 5
VGNC:42291
474965
Species
Name
OMA
EggNOG
Inparanoid
Chimp
potassium voltage-gated channel subfamily Q member 5
Macaque
potassium voltage-gated channel subfamily Q member 5
Mouse
Rat
Dog
potassium voltage-gated channel subfamily Q member 5
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9NR82-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (4)
Neuronal System (R-HSA-112316)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Neuronal System
Reactome
Potassium Channels
Reactome
Voltage gated Potassium channels
Name
Explore in Pharos
Explore in Source
Neuronal System
Potassium Channels
Voltage gated Potassium channels
Protein-Protein Interactions (183)
1 – 10 of 183
MCOLN3
Tchem
Family:  IC
Novelty:  0.03209262
p_int:  0.99984049
p_ni:  0.000110584
p_wrong:  0.000048926
Score:  0.184
Data Source:  BioPlex,STRINGDB
KCNS3
Tclin
Family:  IC
Novelty:  0.05882087
p_int:  0.999684652
p_ni:  0.000293336
p_wrong:  0.000022012
Score:  0.335
Data Source:  BioPlex,STRINGDB
GABRE
Tclin
Family:  IC
Novelty:  0.03814541
p_int:  0.991682542
p_ni:  0.000414641
p_wrong:  0.007902817
Score:  0.189
Data Source:  BioPlex,STRINGDB
HCCS
Tbio
Family:  Enzyme
Novelty:  0.0022585
p_int:  0.987279527
p_ni:  0.000652525
p_wrong:  0.012067948
Score:  0.218
Data Source:  BioPlex,STRINGDB
KCNAB1
Tbio
Family:  IC
Novelty:  0.01413705
Score:  0.932
Data Source:  STRINGDB
KCNAB2
Tbio
Family:  IC
Novelty:  0.01752175
Score:  0.929
Data Source:  STRINGDB
KCNAB3
Tbio
Family:  IC
Novelty:  0.10128237
Score:  0.924
Data Source:  STRINGDB
NCALD
Tbio
Novelty:  0.03665351
Score:  0.916
Data Source:  STRINGDB
CLTC
Tbio
Novelty:  0.00256674
Score:  0.9
Data Source:  STRINGDB
AFTPH
Tbio
Novelty:  0.21887849
Score:  0.9
Data Source:  STRINGDB
Publication Statistics
PubMed Score  76.84

PubMed score by year
PubTator Score  40.56

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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