Tclin KCNQ5 Potassium voltage-gated channel subfamily KQT member 5

Protein Summary

Description

Associates with KCNQ3 to form a potassium channel which contributes to M-type current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons. Therefore, it is important in the regulation of neuronal excitability. May contribute, with other potassium channels, to the molecular diversity of a heterogeneous population of M-channels, varying in kinetic and pharmacological properties, which underlie this physiologically important current. Insensitive to tetraethylammonium, but inhibited by barium, linopirdine and XE991. Activated by niflumic acid and the anticonvulsant retigabine. As the native M-channel, the potassium channel composed of KCNQ3 and KCNQ5 is also suppressed by activation of the muscarinic acetylcholine receptor CHRM1. This gene is a member of the KCNQ potassium channel gene family that is differentially expressed in subregions of the brain and in skeletal muscle. The protein encoded by this gene yields currents that activate slowly with depolarization and can form heteromeric channels with the protein encoded by the KCNQ3 gene. Currents expressed from this protein have voltage dependences and inhibitor sensitivities in common with M-currents. They are also inhibited by M1 muscarinic receptor activation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]

Uniprot Accession IDs

• Q9NR82
• A6NKT6
• A6PVT6
• A8MSQ5
• B4DS33
• B5MC83
• B7ZL37
• F5GZV0
• Q17RE1
• Q5VVP3
• Q86W40
• Q9NRN0
• Q9NYA6

Gene Name

• KCNQ5

Ensembl ID

• ENST00000342056
• ENSP00000345055
• ENSG00000185760
• ENST00000370392
• ENSP00000359419
• ENST00000370398
• ENSP00000359425
• ENST00000628967
• ENSP00000486187
• ENST00000629977
• ENSP00000485743

Symbol

• Kv7.5
• MRD46

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.86
histone modification site profile	0.84
gene perturbation	0.76
microRNA	0.75
protein domain	0.73

Protein Classes

DTO Classes

Protein / Ion Channel / Potassium Channel Family / Kqt Subfamily / Kv7.5/kcnq5 Sub-subfamily / Potassium Voltage-gated Channel Subfamily Kqt Member 5

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 90.11   (req: < 5)

Gene RIFs: 21   (req: <= 3)

Antibodies: 224   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 90.11   (req: >= 5)

Gene RIFs: 21   (req: > 3)

Antibodies: 224   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 9

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 5