Tclin KCNQ5 Potassium voltage-gated channel subfamily KQT member 5

Protein Summary

Description

Associates with KCNQ3 to form a potassium channel which contributes to M-type current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons. Therefore, it is important in the regulation of neuronal excitability. May contribute, with other potassium channels, to the molecular diversity of a heterogeneous population of M-channels, varying in kinetic and pharmacological properties, which underlie this physiologically important current. Insensitive to tetraethylammonium, but inhibited by barium, linopirdine and XE991. Activated by niflumic acid and the anticonvulsant retigabine. As the native M-channel, the potassium channel composed of KCNQ3 and KCNQ5 is also suppressed by activation of the muscarinic acetylcholine receptor CHRM1. This gene is a member of the KCNQ potassium channel gene family that is differentially expressed in subregions of the brain and in skeletal muscle. The protein encoded by this gene yields currents that activate slowly with depolarization and can form heteromeric channels with the protein encoded by the KCNQ3 gene. Currents expressed from this protein have voltage dependences and inhibitor sensitivities in common with M-currents. They are also inhibited by M1 muscarinic receptor activation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]

Uniprot Accession IDs

• Q9NR82
• A6NKT6
• A6PVT6
• A8MSQ5
• B4DS33
• B5MC83
• B7ZL37
• F5GZV0
• Q17RE1
• Q5VVP3
• Q86W40
• Q9NRN0
• Q9NYA6

Gene Name

• KCNQ5

Ensembl ID

• ENST00000342056
• ENSP00000345055
• ENSG00000185760
• ENST00000370392
• ENSP00000359419
• ENST00000370398
• ENSP00000359425
• ENST00000628967
• ENSP00000486187
• ENST00000629977
• ENSP00000485743

Symbol

• Kv7.5
• MRD46

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.86
histone modification site profile	0.84
gene perturbation	0.76
microRNA	0.75
protein domain	0.73

Protein Classes

DTO Classes

Protein / Ion Channel / Potassium Channel Family / Kqt Subfamily / Kv7.5/kcnq5 Sub-subfamily / Potassium Voltage-gated Channel Subfamily Kqt Member 5

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 76.84   (req: < 5)

Gene RIFs: 21   (req: <= 3)

Antibodies: 224   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 76.84   (req: >= 5)

Gene RIFs: 21   (req: > 3)

Antibodies: 224   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 9

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 5

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (5)

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1 – 5 of 5

fampridine

KCNQ5Tclin IC

BLOCKER pIC50 : 4.05

guanidine

KCNQ5Tclin IC

BLOCKER :

amifampridine

KCNQ5Tclin IC

BLOCKER :

gabapentin

KCNQ5Tclin IC

MODULATOR pIC50 : 6.93

retigabine

KCNQ5Tclin IC

ACTIVATOR pEC50 : 5.2

Active Ligands (9)

Explore Active Ligands

1 – 9 of 9

linopirdine

KCNQ5Tclin IC

pKd : 4.8

flindokalner

KCNQ5Tclin IC

: 6.5

XE991

KCNQ5Tclin IC

pKd : 6.1

zinc pyrithione

KCNQ5Tclin IC

: 5.8

CHEMBL4457044

KCNQ5Tclin IC

pEC50 : 7.1

CHEMBL4545892

KCNQ5Tclin IC

pEC50 : 7.1

CHEMBL4438770

KCNQ5Tclin IC

pEC50 : 5.86

CHEMBL4588394

KCNQ5Tclin IC

pEC50 : 6.11

CHEMBL4450214

KCNQ5Tclin IC

pEC50 : 5.69

Protein-Protein Interactions (183)

Explore Interacting Targets

1 – 10 of 183

• See Interactions on String-DB

MCOLN3

Tchem

Family:  IC

Novelty:  0.03209262

p_int:  0.99984049

p_ni:  0.000110584

p_wrong:  0.000048926

Score:  0.184

Data Source:  BioPlex,STRINGDB

KCNS3

Tclin

Family:  IC

Novelty:  0.05882087

p_int:  0.999684652

p_ni:  0.000293336

p_wrong:  0.000022012

Score:  0.335

Data Source:  BioPlex,STRINGDB

GABRE

Tclin

Family:  IC

Novelty:  0.03814541

p_int:  0.991682542

p_ni:  0.000414641

p_wrong:  0.007902817

Score:  0.189

Data Source:  BioPlex,STRINGDB

HCCS

Tbio

Family:  Enzyme

Novelty:  0.0022585

p_int:  0.987279527

p_ni:  0.000652525

p_wrong:  0.012067948

Score:  0.218

Data Source:  BioPlex,STRINGDB

KCNAB1

Tbio

Family:  IC

Novelty:  0.01413705

Score:  0.932

Data Source:  STRINGDB

KCNAB2

Tbio

Family:  IC

Novelty:  0.01752175

Score:  0.929

Data Source:  STRINGDB

KCNAB3

Tbio

Family:  IC

Novelty:  0.10128237

Score:  0.924

Data Source:  STRINGDB

NCALD

Tbio

Novelty:  0.03665351

Score:  0.916

Data Source:  STRINGDB

CLTC

Tbio

Novelty:  0.00256674

Score:  0.9

Data Source:  STRINGDB

AFTPH

Tbio

Novelty:  0.21887849

Score:  0.9

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (4)

Reactome (3)

KEGG (1)

Neuronal System (R-HSA-112316)

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1 – 3 of 3

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Neuronal System	398 targets	R-HSA-112316
Reactome	Potassium Channels	99 targets	R-HSA-1296071
Reactome	Voltage gated Potassium channels	43 targets	R-HSA-1296072

Name	Explore in Pharos	Explore in Source
Neuronal System	398 targets	R-HSA-112316
Potassium Channels	99 targets	R-HSA-1296071
Voltage gated Potassium channels	43 targets	R-HSA-1296072

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (10)

Functions (3)

Components (5)

Processes (2)

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10

1 – 3 of 3

GO Term	Evidence	Assigned by
voltage-gated potassium channel activity	Inferred from Direct Assay (IDA)	UniProtKB
calmodulin binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
delayed rectifier potassium channel activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Disease Associations ()

No disease associations found

GWAS Traits (7)

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5

1 – 5 of 7

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
refractive error measurement	EFO_0007814	2	3	3		82.9
FEV/FEC ratio	EFO_0004713	1	1	1		80.1
pulse pressure measurement	EFO_0005763	1	1	1		73.9
body mass index	EFO_0004340	2	2	2		70.4
peak expiratory flow	EFO_0009718	1	1	1		50.6

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 7

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
refractive error measurement	EFO_0007814	3		82.9
FEV/FEC ratio	EFO_0004713	1		80.1
pulse pressure measurement	EFO_0005763	1		73.9
body mass index	EFO_0004340	2		70.4
peak expiratory flow	EFO_0009718	1		50.6

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UniProt Keyword Find Similar Targets

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3D-structure
Alternative splicing
Cell membrane
Complete proteome
Disease mutation
Ion channel
Ion transport
Membrane
Mental retardation
Phosphoprotein

GWAS Trait Find Similar Targets

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body mass index
FEV/FEC ratio
peak expiratory flow
pulse pressure measurement
refractive error measurement
snoring measurement
unipolar depression

MGI Phenotype Find Similar Targets

No Header	No Header
mortality/aging
nervous system phenotype

IDG Resources

No IDG generated resources found

Orthologs (10)

1 – 5 of 10

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	potassium voltage-gated channel subfamily Q member 5	VGNC:11100	462817
Macaque	potassium voltage-gated channel subfamily Q member 5		715426
Mouse	potassium voltage-gated channel, subfamily Q, member 5	MGI:1924937	226922
Rat	potassium voltage-gated channel subfamily Q member 5	RGD:628848	259273
Dog	potassium voltage-gated channel subfamily Q member 5	VGNC:42291	474965

Species	Name	OMA	EggNOG	Inparanoid
Chimp	potassium voltage-gated channel subfamily Q member 5
Macaque	potassium voltage-gated channel subfamily Q member 5
Mouse	potassium voltage-gated channel, subfamily Q, member 5
Rat	potassium voltage-gated channel subfamily Q member 5
Dog	potassium voltage-gated channel subfamily Q member 5

Publication Statistics

PubMed Score 76.84

PubMed score by year

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PubTator Score 40.56

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Patents

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Related Publications

Text Mined References (35)

GeneRif Annotations (21)

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PMID	Year	Title