PXMP2
Peroxisomal membrane protein 2
Protein Summary
Seems to be involved in pore-forming activity and may contribute to the unspecific permeability of the peroxisomal membrane.
- ENST00000317479
- ENSP00000321271
- ENSG00000176894
- PMP22
- PMP22
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease perturbation | 0.93 | ||
cellular component | 0.79 | ||
virus perturbation | 0.79 | ||
cell type or tissue | 0.75 | ||
histone modification site profile | 0.74 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 5.32 (req: < 5)
Gene RIFs: 0 (req: <= 3)
Antibodies: 111 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 5.32 (req: >= 5)
Gene RIFs: 0 (req: > 3)
Antibodies: 111 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Term: 0
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (38)
PEX19
Novelty: 0.00605342
p_int: 0.999611862
p_ni: 0.00038813
p_wrong: 8e-9
Score: 0.496
Data Source: BioPlex,STRINGDB
SLC1A1
Family: Transporter
Novelty: 0.00218479
p_int: 0.992352503
p_ni: 0.007624237
p_wrong: 0.000023261
Data Source: BioPlex
MME
Family: Enzyme
Novelty: 0.00019144
p_int: 0.990695666
p_ni: 0.009304332
p_wrong: 2e-9
Data Source: BioPlex
SLC18A1
Family: Transporter
Novelty: 0.01135292
p_int: 0.982531505
p_ni: 0.017444464
p_wrong: 0.000024031
Data Source: BioPlex
CMTM8
Novelty: 0.0953768
p_int: 0.979973412
p_ni: 0.020025416
p_wrong: 0.000001171
Data Source: BioPlex
TMCO3
Novelty: 1.16719823
p_int: 0.969767088
p_ni: 0.030232911
p_wrong: 1e-9
Data Source: BioPlex
SLC15A1
Family: Transporter
Novelty: 0.00149723
p_int: 0.969622327
p_ni: 0.030233758
p_wrong: 0.000143915
Data Source: BioPlex
SLC22A16
Family: Transporter
Novelty: 0.03379851
p_int: 0.937802258
p_ni: 0.062197742
p_wrong: 1e-9
Data Source: BioPlex
ERGIC3
Novelty: 0.11095443
p_int: 0.937596363
p_ni: 0.062403636
p_wrong: 1e-9
Data Source: BioPlex
SLC39A9
Family: Transporter
Novelty: 0.06143625
p_int: 0.90837298
p_ni: 0.091610059
p_wrong: 0.000016961
Data Source: BioPlex
Nearest Tclin Targets
Pathways (6)
Reactome (5)
KEGG (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Class I peroxisomal membrane protein import | ||||
Reactome | Glyoxylate metabolism and glycine degradation | ||||
Reactome | Metabolism | ||||
Reactome | Metabolism of amino acids and derivatives | ||||
Reactome | Protein localization | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Class I peroxisomal membrane protein import | ||||
Glyoxylate metabolism and glycine degradation | ||||
Metabolism | ||||
Metabolism of amino acids and derivatives | ||||
Protein localization | ||||
Viral Interactions (0)
Gene Ontology Terms (5)
Components (5)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from High Throughput Direct Assay (HDA) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (8)
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
mathematical ability | 2 | 2 | 2 | 55.8 | |||||
reticulocyte measurement | 1 | 1 | 1 | 52.7 | |||||
smoking status measurement | 2 | 1 | 2 | 51.4 | |||||
mean corpuscular volume | 1 | 1 | 1 | 48.5 | |||||
mean reticulocyte volume | 1 | 1 | 1 | 42.3 | |||||
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
mathematical ability | 2 | 55.8 | |||||
reticulocyte measurement | 1 | 52.7 | |||||
smoking status measurement | 2 | 51.4 | |||||
mean corpuscular volume | 1 | 48.5 | |||||
mean reticulocyte volume | 1 | 42.3 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | peroxisomal membrane protein 2 | 693648 | ||||||
Mouse | MGI:107487 | 19301 | ||||||
Rat | RGD:61812 | 29533 | ||||||
Dog | peroxisomal membrane protein 2 | VGNC:45220 | 486222 | |||||
Horse | peroxisomal membrane protein 2 | VGNC:22057 | 100061603 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Macaque | peroxisomal membrane protein 2 | |||||
Mouse | ||||||
Rat | ||||||
Dog | peroxisomal membrane protein 2 | |||||
Horse | peroxisomal membrane protein 2 | |||||
Publication Statistics
PubMed Score 5.32
PubMed score by year
PubTator Score 6.38
PubTator score by year
Related Publications
Text Mined References (10)
Items per page:
0 of 0
PMID | Year | Title |
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