You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
PXMP2
Peroxisomal membrane protein 2

Protein Summary
Description
Seems to be involved in pore-forming activity and may contribute to the unspecific permeability of the peroxisomal membrane.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000317479
  • ENSP00000321271
  • ENSG00000176894

Symbol
  • PMP22
  • PMP22
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.93
cellular component
0.79
virus perturbation
0.79
cell type or tissue
0.75
histone modification site profile
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.32   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 111   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.32   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 111   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (38)
PEX19
Tbio
Novelty:  0.00605342
p_int:  0.999611862
p_ni:  0.00038813
p_wrong:  8e-9
Score:  0.496
Data Source:  BioPlex,STRINGDB
SLC1A1
Tchem
Family:  Transporter
Novelty:  0.00218479
p_int:  0.992352503
p_ni:  0.007624237
p_wrong:  0.000023261
Data Source:  BioPlex
MME
Tclin
Family:  Enzyme
Novelty:  0.00019144
p_int:  0.990695666
p_ni:  0.009304332
p_wrong:  2e-9
Data Source:  BioPlex
SLC18A1
Tchem
Family:  Transporter
Novelty:  0.01135292
p_int:  0.982531505
p_ni:  0.017444464
p_wrong:  0.000024031
Data Source:  BioPlex
CMTM8
Tbio
Novelty:  0.0953768
p_int:  0.979973412
p_ni:  0.020025416
p_wrong:  0.000001171
Data Source:  BioPlex
TMCO3
Tdark
Novelty:  1.16719823
p_int:  0.969767088
p_ni:  0.030232911
p_wrong:  1e-9
Data Source:  BioPlex
SLC15A1
Tchem
Family:  Transporter
Novelty:  0.00149723
p_int:  0.969622327
p_ni:  0.030233758
p_wrong:  0.000143915
Data Source:  BioPlex
SLC22A16
Tbio
Family:  Transporter
Novelty:  0.03379851
p_int:  0.937802258
p_ni:  0.062197742
p_wrong:  1e-9
Data Source:  BioPlex
ERGIC3
Tbio
Novelty:  0.11095443
p_int:  0.937596363
p_ni:  0.062403636
p_wrong:  1e-9
Data Source:  BioPlex
SLC39A9
Tbio
Family:  Transporter
Novelty:  0.06143625
p_int:  0.90837298
p_ni:  0.091610059
p_wrong:  0.000016961
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Class I peroxisomal membrane protein import (R-HSA-9603798)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class I peroxisomal membrane protein import
Reactome
Glyoxylate metabolism and glycine degradation
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Reactome
Protein localization
Name
Explore in Pharos
Explore in Source
Class I peroxisomal membrane protein import
Glyoxylate metabolism and glycine degradation
Metabolism
Metabolism of amino acids and derivatives
Protein localization
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
2
2
2
55.8
reticulocyte measurement
1
1
1
52.7
smoking status measurement
2
1
2
51.4
mean corpuscular volume
1
1
1
48.5
mean reticulocyte volume
1
1
1
42.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
2
55.8
reticulocyte measurement
1
52.7
smoking status measurement
2
51.4
mean corpuscular volume
1
48.5
mean reticulocyte volume
1
42.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
peroxisomal membrane protein 2
693648
Mouse
MGI:107487
19301
Rat
RGD:61812
29533
Dog
peroxisomal membrane protein 2
VGNC:45220
486222
Horse
peroxisomal membrane protein 2
VGNC:22057
100061603
Species
Name
OMA
EggNOG
Inparanoid
Macaque
peroxisomal membrane protein 2
Mouse
Rat
Dog
peroxisomal membrane protein 2
Horse
peroxisomal membrane protein 2
Publication Statistics
PubMed Score 5.32
PubMed score by year
PubTator Score 6.38
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title