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Tbio
ASAH2
Neutral ceramidase

Protein Summary
Description
Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid at an optimal pH of 6.5-8.5 (PubMed:10781606, PubMed:26190575). Acts as a key regulator of sphingolipid signaling metabolites by generating sphingosine at the cell surface. Acts as a repressor of apoptosis both by reducing C16-ceramide, thereby preventing ceramide-induced apoptosis, and generating sphingosine, a precursor of the antiapoptotic factor sphingosine 1-phosphate. Probably involved in the digestion of dietary sphingolipids in intestine by acting as a key enzyme for the catabolism of dietary sphingolipids and regulating the levels of bioactive sphingolipid metabolites in the intestinal tract. Ceramidases (EC 3.5.1.23), such as ASAH2, catalyze hydrolysis of the N-acyl linkage of ceramide, a second messenger in a variety of cellular events, to produce sphingosine. Sphingosine exerts both mitogenic and apoptosis-inducing activities, and its phosphorylated form functions as an intra- and intercellular second ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000395526
  • ENSP00000378897
  • ENSG00000188611
  • ENST00000447815
  • ENSP00000388206

Symbol
  • HNAC1
  • HNAC1
  • BCDase
  • LCDase
  • NCDase
  • N-CDase
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.67
tissue sample
0.64
transcription factor perturbation
0.61
cellular component
0.59
virus perturbation
0.55


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 79.3   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 190   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 79.3   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 190   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (59)
1 – 10 of 59
CERK
Tchem
Family:  Kinase
Novelty:  0.0103948
Score:  0.98
Data Source:  STRINGDB
SPHK2
Tchem
Family:  Kinase
Novelty:  0.00454527
Score:  0.977
Data Source:  STRINGDB
SPHK1
Tchem
Family:  Kinase
Novelty:  0.00147889
Score:  0.977
Data Source:  STRINGDB
ACER2
Tchem
Family:  Enzyme
Novelty:  0.040885
Score:  0.972
Data Source:  STRINGDB
ACER1
Tbio
Family:  Enzyme
Novelty:  0.05571844
Score:  0.971
Data Source:  STRINGDB
SGMS2
Tchem
Family:  Enzyme
Novelty:  0.01360669
Score:  0.966
Data Source:  STRINGDB
KDSR
Tbio
Family:  Enzyme
Novelty:  0.0408411
Score:  0.965
Data Source:  STRINGDB
ASAH1
Tchem
Family:  Enzyme
Novelty:  0.00374228
Score:  0.962
Data Source:  STRINGDB
SGMS1
Tchem
Family:  Enzyme
Novelty:  0.01717229
Score:  0.96
Data Source:  STRINGDB
GBA2
Tchem
Family:  Enzyme
Novelty:  0.01340895
Score:  0.958
Data Source:  STRINGDB
Pathways (10)
Glycosphingolipid metabolism (R-HSA-1660662)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glycosphingolipid metabolism
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Sphingolipid metabolism
Name
Explore in Pharos
Explore in Source
Glycosphingolipid metabolism
Metabolism
Metabolism of lipids
Sphingolipid metabolism
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
N-acylsphingosine amidohydrolase 2
703913
Mouse
MGI:1859310
54447
Rat
RGD:69410
114104
Horse
N-acylsphingosine amidohydrolase 2
100071829
Cow
N-acylsphingosine amidohydrolase 2
100336736
Species
Name
OMA
EggNOG
Inparanoid
Macaque
N-acylsphingosine amidohydrolase 2
Mouse
Rat
Horse
N-acylsphingosine amidohydrolase 2
Cow
N-acylsphingosine amidohydrolase 2
Publication Statistics
PubMed Score 79.30
PubMed score by year
PubTator Score 25.95
PubTator score by year