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Tbio
DLL4
Delta-like protein 4

Protein Summary
Description
Involved in the Notch signaling pathway as Notch ligand (PubMed:11134954). Activates NOTCH1 and NOTCH4. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting (PubMed:20616313). Essential for retinal progenitor proliferation. Required for suppressing rod fates in late retinal progenitors as well as for proper generation of other retinal cell types (By similarity). During spinal cord neurogenesis, inhibits V2a interneuron fate (PubMed:17728344). This gene is a homolog of the Drosophila delta gene. The delta gene family encodes Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000249749
  • ENSP00000249749
  • ENSG00000128917
  • ENST00000650082
  • ENSP00000497860

Symbol
  • AOS6
  • delta4
  • hdelta2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.95
protein domain
0.92
transcription factor binding site profile
0.87
biological term
0.75
tissue sample
0.73


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 431.28   (req: < 5)
Gene RIFs: 110   (req: <= 3)
Antibodies: 778   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 431.28   (req: >= 5)
Gene RIFs: 110   (req: > 3)
Antibodies: 778   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 31
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
1
2
2
72.3
intelligence
3
1
1
5.7
45.2
age at menopause
1
1
1
44.2
cognitive function measurement
3
1
3
40.7
self reported educational attainment
1
1
1
33.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
2
72.3
intelligence
1
5.7
45.2
age at menopause
1
44.2
cognitive function measurement
3
40.7
self reported educational attainment
1
33.1
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
delta like canonical Notch ligand 4
VGNC:10413
453344
Macaque
delta like canonical Notch ligand 4
704898
Mouse
MGI:1859388
54485
Rat
RGD:1309740
311332
Dog
delta like canonical Notch ligand 4
VGNC:39987
607575
Species
Name
OMA
EggNOG
Inparanoid
Chimp
delta like canonical Notch ligand 4
Macaque
delta like canonical Notch ligand 4
Mouse
Rat
Dog
delta like canonical Notch ligand 4
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9NR61-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (70)
Activated NOTCH1 Transmits Signal to the Nucleus (R-HSA-2122948)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 21
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activated NOTCH1 Transmits Signal to the Nucleus
Reactome
Constitutive Signaling by NOTCH1 HD Domain Mutants
Reactome
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Reactome
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Reactome
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
Name
Explore in Pharos
Explore in Source
Activated NOTCH1 Transmits Signal to the Nucleus
Constitutive Signaling by NOTCH1 HD Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
Gene Ontology Terms (33)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (114)
1 – 10 of 114
ADAM10
Tchem
Family:  Enzyme
Novelty:  0.00160129
Score:  0.989
Data Source:  Reactome,STRINGDB
NEURL1B
Tdark
Family:  Enzyme
Novelty:  0.16762429
Score:  0.971
Data Source:  STRINGDB
NEURL1
Tbio
Family:  Enzyme
Novelty:  0.05370537
Score:  0.97
Data Source:  STRINGDB
NOTCH1
Tchem
Novelty:  0.00012547
Score:  0.967
Data Source:  Reactome,STRINGDB
NOTCH4
Tchem
Novelty:  0.00471643
Score:  0.96
Data Source:  Reactome,STRINGDB
ADAM17
Tchem
Family:  Enzyme
Novelty:  0.00121971
Score:  0.95
Data Source:  STRINGDB
NOTCH3
Tchem
Novelty:  0.000953
Score:  0.947
Data Source:  Reactome,STRINGDB
NOTCH2
Tchem
Novelty:  0.00195617
Score:  0.946
Data Source:  Reactome,STRINGDB
MIB1
Tbio
Family:  Enzyme
Novelty:  0.03288048
Score:  0.945
Data Source:  STRINGDB
NCSTN
Tbio
Novelty:  0.00453935
Score:  0.94
Data Source:  STRINGDB
Publication Statistics
PubMed Score  431.28

PubMed score by year
PubTator Score  310.38

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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