Tbio DLL4 Delta-like protein 4

Protein Summary

Description

Involved in the Notch signaling pathway as Notch ligand (PubMed:11134954). Activates NOTCH1 and NOTCH4. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting (PubMed:20616313). Essential for retinal progenitor proliferation. Required for suppressing rod fates in late retinal progenitors as well as for proper generation of other retinal cell types (By similarity). During spinal cord neurogenesis, inhibits V2a interneuron fate (PubMed:17728344). This gene is a homolog of the Drosophila delta gene. The delta gene family encodes Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9NR61
• Q3KP23
• Q9NQT9

Gene Name

• DLL4

Ensembl ID

• ENST00000249749
• ENSP00000249749
• ENSG00000128917
• ENST00000650082
• ENSP00000497860

Symbol

• AOS6
• delta4
• hdelta2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.95
protein domain	0.92
transcription factor binding site profile	0.87
biological term	0.75
tissue sample	0.73

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 492.63   (req: < 5)

Gene RIFs: 138   (req: <= 3)

Antibodies: 778   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 492.63   (req: >= 5)

Gene RIFs: 138   (req: > 3)

Antibodies: 778   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 31

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0