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Tbio
BATF3
Basic leucine zipper transcriptional factor ATF-like 3

Protein Summary
Description
AP-1 family transcription factor that controls the differentiation of CD8(+) thymic conventional dendritic cells in the immune system. Required for development of CD8-alpha(+) classical dendritic cells (cDCs) and related CD103(+) dendritic cells that cross-present antigens to CD8 T-cells and produce interleukin-12 (IL12) in response to pathogens (By similarity). Acts via the formation of a heterodimer with JUN family proteins that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3' and regulates expression of target genes. This gene encodes a member of the basic leucine zipper protein family. The encoded protein functions as a transcriptional repressor when heterodimerizing with JUN. The protein may play a role in repression of interleukin-2 and matrix metalloproteinase-1 transcription.[provided by RefSeq, Feb 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000243440
  • ENSP00000243440
  • ENSG00000123685

Symbol
  • SNFT
  • JDP1
  • SNFT
  • JUNDM1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.88
histone modification site profile
0.85
biological process
0.66
cell type or tissue
0.65
tissue sample
0.65


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 71.53   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 129   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 71.53   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 129   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1
10.7
1
1
0
1.1
7.6
1
1
0
1.1
4.2
lymphocyte percentage of leukocytes
1
1
1
2.5
neutrophil percentage of leukocytes
1
1
1
2.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1
10.7
0
1.1
7.6
0
1.1
4.2
lymphocyte percentage of leukocytes
1
2.5
neutrophil percentage of leukocytes
1
2.2
Pathways (56)
Items per page:
1 – 1 of 1
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
PD-L1 expression and PD-1 checkpoint pathway in cancer
Name
Explore in Pharos
Explore in Source
PD-L1 expression and PD-1 checkpoint pathway in cancer
Gene Ontology Terms (11)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (90)
1 – 10 of 90
JUNB
Tbio
Family: TF
Novelty: 0.00841656
p_int: 1
Score: 0.876
Data Source: BioPlex,STRINGDB
BACH2
Tbio
Family: TF
Novelty: 0.00932069
p_int: 0.999999759
p_ni: 2.41e-7
Score: 0.41
Data Source: BioPlex,STRINGDB
ATF7
Tbio
Family: TF
Novelty: 0.01470313
p_int: 0.99999923
p_ni: 7.7e-7
Score: 0.702
Data Source: BioPlex,STRINGDB
RTL6
Tbio
Novelty: 0.12824182
p_int: 0.999998562
p_ni: 7.84e-7
p_wrong: 6.53e-7
Score: 0.571
Data Source: BioPlex,STRINGDB
ZNF451
Tbio
Family: TF
Novelty: 0.13852406
p_int: 0.999998032
p_ni: 0.000001342
p_wrong: 6.26e-7
Score: 0.348
Data Source: BioPlex,STRINGDB
JUND
Tbio
Family: TF
Novelty: 0.00277701
p_int: 0.999997697
p_ni: 0.00000217
p_wrong: 1.33e-7
Score: 0.898
Data Source: BioPlex,STRINGDB
ATF2
Tbio
Family: TF
Novelty: 0.00457832
p_int: 0.999997207
p_ni: 0.000002793
p_wrong: 1e-9
Score: 0.682
Data Source: BioPlex,STRINGDB
BACH1
Tbio
Family: TF
Novelty: 0.04011328
p_int: 0.999996282
p_ni: 0.000003708
p_wrong: 1e-8
Score: 0.216
Data Source: BioPlex,STRINGDB
ZBTB10
Tbio
Family: TF
Novelty: 0.05707286
p_int: 0.999994371
p_ni: 0.000005621
p_wrong: 7e-9
Score: 0.209
Data Source: BioPlex,STRINGDB
JUN
Tchem
Family: TF
Novelty: 0.00006856
p_int: 0.999968347
p_ni: 0.000031652
p_wrong: 1e-9
Score: 0.991
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  71.53

PubMed score by year
PubTator Score  20.62

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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