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Tbio
EIF2B3
Translation initiation factor eIF-2B subunit gamma

Protein Summary
Description
Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP. The protein encoded by this gene is one of the subunits of initiation factor eIF2B, which catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP. It has also been found to function as a cofactor of hepatitis C virus internal ribosome entry site-mediated translation. Mutations in this gene have been associated with leukodystrophy with vanishing white matter. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000360403
  • ENSP00000353575
  • ENSG00000070785
  • ENST00000372183
  • ENSP00000361257
  • ENST00000620860
  • ENSP00000483996

Symbol
  • EIF-2B
  • EIF2Bgamma
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.84
interacting protein
0.79
histone modification site profile
0.74
biological process
0.68
tissue
0.63


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.58   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 248   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.58   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 248   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
eukaryotic translation initiation factor 2B subunit gamma
VGNC:7401
456543
Macaque
eukaryotic translation initiation factor 2B subunit gamma
705862
Mouse
MGI:1313286
108067
Rat
RGD:620821
171145
Dog
eukaryotic translation initiation factor 2B subunit gamma
VGNC:40262
475379
Species
Name
OMA
EggNOG
Inparanoid
Chimp
eukaryotic translation initiation factor 2B subunit gamma
Macaque
eukaryotic translation initiation factor 2B subunit gamma
Mouse
Rat
Dog
eukaryotic translation initiation factor 2B subunit gamma
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9NR50-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (8)
Cap-dependent Translation Initiation (R-HSA-72737)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cap-dependent Translation Initiation
Reactome
Eukaryotic Translation Initiation
Reactome
Metabolism of proteins
Reactome
Recycling of eIF2:GDP
Reactome
Translation
Name
Explore in Pharos
Explore in Source
Cap-dependent Translation Initiation
Eukaryotic Translation Initiation
Metabolism of proteins
Recycling of eIF2:GDP
Translation
Protein-Protein Interactions (101)
1 – 10 of 101
EIF2B5
Tbio
Novelty: 0.0102209
p_int: 0.999997689
p_ni: 0.000002311
Score: 0.999
Data Source: BioPlex,STRINGDB
EIF2B2
Tbio
Novelty: 0.03253919
p_int: 0.999997448
p_ni: 0.000002552
Score: 0.999
Data Source: BioPlex,STRINGDB
GYPB
Tbio
Novelty: 0.00442195
p_int: 0.999948403
p_ni: 0.000051597
Data Source: BioPlex
GPR183
Tchem
Family: GPCR
Novelty: 0.02005679
p_int: 0.99981029
p_ni: 0.00018971
Score: 0.185
Data Source: BioPlex,STRINGDB
BTC
Tbio
Novelty: 0.00673076
p_int: 0.999615122
p_ni: 0.000384878
Data Source: BioPlex
VTI1B
Tbio
Novelty: 0.00955467
p_int: 0.999022828
p_ni: 0.000977172
Data Source: BioPlex
SYT1
Tbio
Novelty: 0.00176103
p_int: 0.998769377
p_ni: 0.001230623
Data Source: BioPlex
SIGLECL1
Tdark
p_int: 0.998664261
p_ni: 0.001335739
Data Source: BioPlex
P2RX4
Tchem
Family: IC
Novelty: 0.00242958
p_int: 0.996952978
p_ni: 0.003047022
Data Source: BioPlex
NECTIN4
Tclin
Novelty: 0.00694563
p_int: 0.996591015
p_ni: 0.003408985
Score: 0.596
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  21.58

PubMed score by year
PubTator Score  15.83

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer