EIF2B3
Translation initiation factor eIF-2B subunit gamma
Protein Summary
Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP. The protein encoded by this gene is one of the subunits of initiation factor eIF2B, which catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP. It has also been found to function as a cofactor of hepatitis C virus internal ribosome entry site-mediated translation. Mutations in this gene have been associated with leukodystrophy with vanishing white matter. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
- ENST00000360403
- ENSP00000353575
- ENSG00000070785
- ENST00000372183
- ENSP00000361257
- ENST00000620860
- ENSP00000483996
- EIF-2B
- EIF2Bgamma
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
kinase perturbation | 0.84 | ||
interacting protein | 0.79 | ||
histone modification site profile | 0.74 | ||
biological process | 0.68 | ||
tissue | 0.63 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 28.08 (req: < 5)
Gene RIFs: 6 (req: <= 3)
Antibodies: 248 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 28.08 (req: >= 5)
Gene RIFs: 6 (req: > 3)
Antibodies: 248 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 10
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0