Tbio ASH1L Histone-lysine N-methyltransferase ASH1L

Protein Summary

Description

Histone methyltransferase specifically methylating 'Lys-36' of histone H3 (H3K36me). This gene encodes a member of the trithorax group of transcriptional activators. The protein contains four AT hooks, a SET domain, a PHD-finger motif, and a bromodomain. It is localized to many small speckles in the nucleus, and also to cell-cell tight junctions. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9NR48
• Q59GP1
• Q5T714
• Q5T715
• Q9P2C7

Gene Name

• ASH1L

Ensembl ID

• ENST00000368346
• ENSP00000357330
• ENSG00000116539
• ENST00000392403
• ENSP00000376204

Symbol

• KIAA1420
• KMT2H
• ASH1
• KMT2H
• MRD52
• ASH1L1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	1
biological process	0.88
disease perturbation	0.87
molecular function	0.84
microRNA	0.8

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.84   (req: < 5)

Gene RIFs: 28   (req: <= 3)

Antibodies: 156   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.84   (req: >= 5)

Gene RIFs: 28   (req: > 3)

Antibodies: 156   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0