You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
ASH1L
Histone-lysine N-methyltransferase ASH1L

Protein Summary
Description
Histone methyltransferase specifically methylating 'Lys-36' of histone H3 (H3K36me). This gene encodes a member of the trithorax group of transcriptional activators. The protein contains four AT hooks, a SET domain, a PHD-finger motif, and a bromodomain. It is localized to many small speckles in the nucleus, and also to cell-cell tight junctions. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000368346
  • ENSP00000357330
  • ENSG00000116539
  • ENST00000392403
  • ENSP00000376204

Symbol
  • KIAA1420
  • KMT2H
  • ASH1
  • KMT2H
  • MRD52
  • ASH1L1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
biological process
0.88
disease perturbation
0.87
molecular function
0.84
microRNA
0.8


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.32   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 156   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.32   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 156   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.6
85
vitamin D measurement
1
1
1
79
appendicular lean mass
1
1
1
71.5
1
1
0
4.3
63.7
reticulocyte measurement
2
1
2
56.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.6
85
vitamin D measurement
1
79
appendicular lean mass
1
71.5
0
4.3
63.7
reticulocyte measurement
2
56.2
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ASH1 like histone lysine methyltransferase
VGNC:11748
107971434
Mouse
MGI:2183158
192195
Rat
RGD:1306350
310638
Dog
ASH1 like histone lysine methyltransferase
VGNC:50622
480128
Horse
ASH1 like histone lysine methyltransferase
VGNC:50585
100057386
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ASH1 like histone lysine methyltransferase
Mouse
Rat
Dog
ASH1 like histone lysine methyltransferase
Horse
ASH1 like histone lysine methyltransferase
Protein Structure (7 Structures, 9 AlphaFold Models)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 7
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (5)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
PKMTs methylate histone lysines
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
PKMTs methylate histone lysines
Gene Ontology Terms (29)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HGNC
Inferred from Sequence Model (ISM)
NTNU_SB
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (119)
1 – 10 of 119
MORF4L2
Tbio
Novelty: 0.09897629
p_int: 0.999998505
p_ni: 0.000001495
Score: 0.67
Data Source: BioPlex,STRINGDB
EIF2B5
Tbio
Novelty: 0.0102209
p_int: 0.99999075
p_ni: 0.00000925
Data Source: BioPlex
MORF4L1
Tbio
Family: Epigenetic
Novelty: 0.01696001
p_int: 0.983892389
p_ni: 0.016107609
p_wrong: 2e-9
Score: 0.632
Data Source: BioPlex,STRINGDB
NXF2
Tbio
Novelty: 0.04733504
p_int: 0.981696802
p_ni: 0.018301654
p_wrong: 0.000001544
Data Source: BioPlex
CDX1
Tbio
Family: TF
Novelty: 0.00815821
p_int: 0.918193239
p_ni: 0.07525435
p_wrong: 0.006552411
Data Source: BioPlex
THAP7
Tbio
Family: TF
Novelty: 0.37300241
p_int: 0.796336405
p_ni: 0.200105423
p_wrong: 0.003558173
Score: 0.207
Data Source: BioPlex,STRINGDB
YY1AP1
Tbio
Novelty: 0.06862573
Score: 0.906
Data Source: STRINGDB
GON4L
Tbio
Novelty: 0.06166736
Score: 0.905
Data Source: STRINGDB
SETD2
Tchem
Family: Epigenetic
Novelty: 0.00178899
Score: 0.896
Data Source: STRINGDB
USP34
Tbio
Family: Enzyme
Novelty: 0.16444192
Score: 0.864
Data Source: STRINGDB
Publication Statistics
PubMed Score  37.32

PubMed score by year
PubTator Score  26.78

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: