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Tbio
SH3GLB2
Endophilin-B2

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000372554
  • ENSP00000361634
  • ENSG00000148341
  • ENST00000372559
  • ENSP00000361640
  • ENST00000372564
  • ENSP00000361645

Symbol
  • KIAA1848
  • RRIG1
  • PP6569
  • PP9455
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.85
kinase perturbation
0.76
transcription factor perturbation
0.74
transcription factor binding site profile
0.6
protein domain
0.58


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.41   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 121   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.41   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 121   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (44)
SH3KBP1
Tbio
Family:  Enzyme
Novelty:  0.01454593
Score:  0.94
Data Source:  STRINGDB
CBLB
Tbio
Family:  Enzyme
Novelty:  0.08068177
Score:  0.818
Data Source:  STRINGDB
CBL
Tbio
Family:  Enzyme
Novelty:  0.00114929
Score:  0.818
Data Source:  STRINGDB
CBLC
Tbio
Family:  Enzyme
Novelty:  0.14017765
Score:  0.814
Data Source:  STRINGDB
BIN1
Tbio
Novelty:  0.00312612
Score:  0.681
Data Source:  STRINGDB
PI4KB
Tchem
Family:  Kinase
Novelty:  0.00856875
Score:  0.677
Data Source:  STRINGDB
DECR2
Tbio
Family:  Enzyme
Novelty:  0.03928974
Score:  0.672
Data Source:  STRINGDB
UXT
Tbio
Novelty:  0.0272609
Score:  0.624
Data Source:  STRINGDB
SYNJ1
Tchem
Novelty:  0.01030746
Score:  0.624
Data Source:  STRINGDB
FGFR3
Tclin
Family:  Kinase
Novelty:  0.00071612
Score:  0.612
Data Source:  STRINGDB
Nearest Tclin Targets (6)
Explore Nearest Tclin Targets
1 – 5 of 6
FGFR2
Tclin
Family:  Kinase
KEGG Distance:  2
Common Pathways:  1
PDGFRA
Tclin
Family:  Kinase
KEGG Distance:  2
Common Pathways:  1
EGFR
Tclin
Family:  Kinase
KEGG Distance:  2
Common Pathways:  1
FGFR4
Tclin
Family:  Kinase
KEGG Distance:  2
Common Pathways:  1
FGFR3
Tclin
Family:  Kinase
KEGG Distance:  2
Common Pathways:  1
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood metabolite measurement
3
3
6
97.2
metabolite measurement
1
1
1
83.2
red blood cell distribution width
2
1
2
74.5
red blood cell density measurement
1
1
1
53.3
1
1
0
2.6
26.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood metabolite measurement
6
97.2
metabolite measurement
1
83.2
red blood cell distribution width
2
74.5
red blood cell density measurement
1
53.3
0
2.6
26.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SH3 domain containing GRB2 like, endophilin B2
107976792
Macaque
SH3 domain containing GRB2 like, endophilin B2
716994
Mouse
MGI:2385131
227700
Rat
RGD:1305886
311848
Dog
SH3 domain containing GRB2 like, endophilin B2
VGNC:46128
491306
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SH3 domain containing GRB2 like, endophilin B2
Macaque
SH3 domain containing GRB2 like, endophilin B2
Mouse
Rat
Dog
SH3 domain containing GRB2 like, endophilin B2
Publication Statistics
PubMed Score 5.41
PubMed score by year
PubTator Score 6.94
PubTator score by year
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Related Publications
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PMID
Year
Title