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Tbio
MAN1C1
Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC

Protein Classes
Protein Summary
Description
Involved in the maturation of Asn-linked oligosaccharides. Trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce first Man(8)GlcNAc(2) then Man(6)GlcNAc and a small amount of Man(5)GlcNAc.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000374332
  • ENSP00000363452
  • ENSG00000117643

Symbol
  • MAN1A3
  • MAN1C
  • HMIC
  • MAN1C
  • MAN1A3
  • pp6318
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.79
transcription factor binding site profile
0.77
transcription factor
0.72
virus perturbation
0.72
cellular component
0.68


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.86   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 52   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.86   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 52   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
4
5
98
platelet count
2
2
2
88
apolipoprotein B measurement
1
2
2
73.1
hemoglobin measurement
2
2
2
66.6
red blood cell density measurement
1
1
1
64.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
5
98
platelet count
2
88
apolipoprotein B measurement
2
73.1
hemoglobin measurement
2
66.6
red blood cell density measurement
1
64.9
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mannosidase alpha class 1C member 1
VGNC:8071
736491
Macaque
mannosidase alpha class 1C member 1
719686
Mouse
MGI:2446214
230815
Rat
RGD:1309672
362625
Dog
mannosidase alpha class 1C member 1
VGNC:42944
478178
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mannosidase alpha class 1C member 1
Macaque
mannosidase alpha class 1C member 1
Mouse
Rat
Dog
mannosidase alpha class 1C member 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9NR34-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (15)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
Intra-Golgi and retrograde Golgi-to-ER traffic
Reactome
Intra-Golgi traffic
Reactome
Membrane Trafficking
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
Intra-Golgi and retrograde Golgi-to-ER traffic
Intra-Golgi traffic
Membrane Trafficking
Metabolism of proteins
Protein-Protein Interactions (45)
1 – 10 of 45
FAM241A
Tdark
Novelty:  1.04041354
p_int:  0.999999999
p_wrong:  1e-9
Data Source:  BioPlex
MAN2A2
Tbio
Family:  Enzyme
Novelty:  0.07098345
Score:  0.963
Data Source:  STRINGDB
MGAT1
Tchem
Family:  Enzyme
Novelty:  0.01024931
Score:  0.953
Data Source:  STRINGDB
MAN2A1
Tbio
Family:  Enzyme
Novelty:  0.03034058
Score:  0.944
Data Source:  STRINGDB
COG4
Tbio
Novelty:  0.03809668
Score:  0.933
Data Source:  STRINGDB
COG7
Tbio
Novelty:  0.07137701
Score:  0.91
Data Source:  STRINGDB
COG6
Tbio
Novelty:  0.02874093
Score:  0.908
Data Source:  STRINGDB
GANAB
Tchem
Family:  Enzyme
Novelty:  0.01211958
Score:  0.908
Data Source:  STRINGDB
COG5
Tbio
Novelty:  0.04017657
Score:  0.908
Data Source:  STRINGDB
COG1
Tbio
Novelty:  0.0124285
Score:  0.907
Data Source:  STRINGDB
Publication Statistics
PubMed Score  8.86

PubMed score by year
PubTator Score  148.62

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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