Tbio SAR1A GTP-binding protein SAR1a

Protein Summary

Description

Involved in transport from the endoplasmic reticulum to the Golgi apparatus (By similarity). Required to maintain SEC16A localization at discrete locations on the ER membrane perhaps by preventing its dissociation. SAR1A-GTP-dependent assembly of SEC16A on the ER membrane forms an organized scaffold defining endoplasmic reticulum exit sites (ERES).

Uniprot Accession IDs

• Q9NR31
• B4DQ19

Gene Name

• SAR1A

Ensembl ID

• ENST00000373238
• ENSP00000362335
• ENSG00000079332
• ENST00000373241
• ENSP00000362338
• ENST00000373242
• ENSP00000362339
• ENST00000431664
• ENSP00000399698

Symbol

• SAR1
• SARA
• SARA1
• SAR1
• Sara
• SARA1
• masra2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
kinase perturbation	1
transcription factor perturbation	0.96
interacting protein	0.94
virus perturbation	0.83

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.85   (req: < 5)

Gene RIFs: 22   (req: <= 3)

Antibodies: 183   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.85   (req: >= 5)

Gene RIFs: 22   (req: > 3)

Antibodies: 183   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0