Tchem PRMT8 Protein arginine N-methyltransferase 8

Protein Summary

Description

S-adenosyl-L-methionine-dependent and membrane-associated arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA) in proteins such as NIFK, myelin basic protein, histone H4, H2A and H2A/H2B dimer (PubMed:16051612, PubMed:17925405, PubMed:26876602, PubMed:26529540). Able to mono- and dimethylate EWS protein; however its precise role toward EWS remains unclear as it still interacts with fully methylated EWS (PubMed:18320585). Arginine methylation is a widespread posttranslational modification mediated by arginine methyltransferases, such as PRMT8. Arginine methylation is involved in a number of cellular processes, including DNA repair, RNA transcription, signal transduction, protein compartmentalization, and possibly protein translation (Lee et al., 2005 [PubMed 16051612]).[supplied by OMIM, Mar 2008]

Uniprot Accession IDs

• Q9NR22
• B2RDP0
• Q8TBJ8

Gene Name

• PRMT8

Ensembl ID

• ENST00000382622
• ENSP00000372067
• ENSG00000111218
• ENST00000452611
• ENSP00000414507

Symbol

• HRMT1L3
• HRMT1L4
• HRMT1L3
• HRMT1L4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
pathway	0.95
molecular function	0.73
cell line	0.61
PubMedID	0.61
transcription factor binding site profile	0.58

Protein Classes

DTO Classes

Protein / Epigenetic Regulator / Writer / Protein Methyltransferase / Protein Arginine Methyltransferase / Protein Arginine N-methyltransferase 8

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.47   (req: < 5)

Gene RIFs: 11   (req: <= 3)

Antibodies: 164   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.47   (req: >= 5)

Gene RIFs: 11   (req: > 3)

Antibodies: 164   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 25

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0