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Tchem
DYRK4
Dual specificity tyrosine-phosphorylation-regulated kinase 4

Protein Summary
Description
Possible non-essential role in spermiogenesis. This gene encodes an enzyme that belongs to a conserved family of serine/threonine protein kinases. Members of this dual specificity kinase family are thought to function in the regulation of cell differentiation and proliferation, survival, and in development. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Aug 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000010132
  • ENSP00000010132
  • ENSG00000010219
  • ENST00000540757
  • ENSP00000441755
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.96
protein domain
0.73
cell line
0.68
tissue sample
0.66
PubMedID
0.6


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.93   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 256   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.93   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 256   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (6)
Dark Kinase Knowledgebase
Thumbnail image for Dark Kinase Knowledgebase
The Dark Kinase Knowledgebase is an an online compendium of knowledge and experimental results of understudied kinases.
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (29)
CALML5
Tbio
Novelty:  0.03240679
p_int:  0.80372336
p_ni:  0.19627664
Score:  0.332
Data Source:  BioPlex,STRINGDB
DCAF7
Tbio
Novelty:  0.02609518
Score:  0.864
Data Source:  STRINGDB
SLC35E3
Tdark
Family:  Transporter
Novelty:  1.35367021
Score:  0.739
Data Source:  STRINGDB
NRIP2
Tdark
Novelty:  0.5598619
Score:  0.732
Data Source:  STRINGDB
CAND1
Tbio
Novelty:  0.0196525
Score:  0.631
Data Source:  STRINGDB
CPSF6
Tbio
Novelty:  0.01263178
Score:  0.605
Data Source:  STRINGDB
KATNAL1
Tbio
Family:  Enzyme
Novelty:  0.11227609
Score:  0.603
Data Source:  STRINGDB
KATNA1
Tbio
Family:  Enzyme
Novelty:  0.05656063
Score:  0.603
Data Source:  STRINGDB
NUP107
Tbio
Novelty:  0.01994155
Score:  0.588
Data Source:  STRINGDB
SCML2
Tbio
Family:  Epigenetic
Novelty:  0.04486535
Score:  0.517
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (8)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
2
1
1
7.5
83
glomerular filtration rate
3
3
3
74.9
phosphorus measurement
1
1
1
56.2
calcium measurement
1
1
1
25.8
gut microbiome measurement
1
1
1
16.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
1
7.5
83
glomerular filtration rate
3
74.9
phosphorus measurement
1
56.2
calcium measurement
1
25.8
gut microbiome measurement
1
16.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
dual specificity tyrosine phosphorylation regulated kinase 4
VGNC:8403
466926
Macaque
dual specificity tyrosine phosphorylation regulated kinase 4
710999
Mouse
MGI:1330292
101320
Rat
RGD:1306800
312721
Dog
dual specificity tyrosine phosphorylation regulated kinase 4
477720
Species
Name
OMA
EggNOG
Inparanoid
Chimp
dual specificity tyrosine phosphorylation regulated kinase 4
Macaque
dual specificity tyrosine phosphorylation regulated kinase 4
Mouse
Rat
Dog
dual specificity tyrosine phosphorylation regulated kinase 4
Publication Statistics
PubMed Score 4.93
PubMed score by year
PubTator Score 2.06
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title