ACSS2
Acetyl-coenzyme A synthetase, cytoplasmic
Protein Summary
Activates acetate so that it can be used for lipid synthesis or for energy generation. This gene encodes a cytosolic enzyme that catalyzes the activation of acetate for use in lipid synthesis and energy generation. The protein acts as a monomer and produces acetyl-CoA from acetate in a reaction that requires ATP. Expression of this gene is regulated by sterol regulatory element-binding proteins, transcription factors that activate genes required for the synthesis of cholesterol and unsaturated fatty acids. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2009]
- ENST00000253382
- ENSP00000253382
- ENSG00000131069
- ENST00000360596
- ENSP00000353804
- ACAS2
- ACS
- ACSA
- ACAS2
- ACECS
- dJ1161H23.1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor perturbation | 0.94 | ||
molecular function | 0.91 | ||
kinase perturbation | 0.84 | ||
transcription factor binding site profile | 0.77 | ||
small molecule perturbation | 0.75 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 220.75 (req: < 5)
Gene RIFs: 21 (req: <= 3)
Antibodies: 381 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 220.75 (req: >= 5)
Gene RIFs: 21 (req: > 3)
Antibodies: 381 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 221
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (221)
Protein-Protein Interactions (164)
Nearest Tclin Targets (2)
Upstream (1)
Downstream (1)
1 – 1 of 1
Pathways (44)
Reactome (7)
KEGG (6)
PathwayCommons (8)
WikiPathways (23)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Biological oxidations | ||||
Reactome | Ethanol oxidation | ||||
Reactome | Metabolism | ||||
Reactome | Mitochondrial biogenesis | ||||
Reactome | Organelle biogenesis and maintenance | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Biological oxidations | ||||
Ethanol oxidation | ||||
Metabolism | ||||
Mitochondrial biogenesis | ||||
Organelle biogenesis and maintenance | ||||
Viral Interactions (0)
Gene Ontology Terms (13)
Functions (3)
Components (5)
Processes (5)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred by Curator (IC) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (25)
Items per page:
1 – 5 of 25
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
appendicular lean mass | 3 | 3 | 7 | 97.1 | |||||
suntan | 1 | 2 | 2 | 96 | |||||
glomerular filtration rate | 3 | 2 | 2 | 8.6 | 92.4 | ||||
BMI-adjusted hip circumference | 3 | 4 | 5 | 86.8 | |||||
electrocardiography | 1 | 1 | 41 | 75.5 | |||||
Items per page:
1 – 5 of 25
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
appendicular lean mass | 7 | 97.1 | |||||
suntan | 2 | 96 | |||||
glomerular filtration rate | 2 | 8.6 | 92.4 | ||||
BMI-adjusted hip circumference | 5 | 86.8 | |||||
electrocardiography | 41 | 75.5 | |||||
Find similar targets by:
IDG Resources
Orthologs (14)
1 – 5 of 14
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | acyl-CoA synthetase short chain family member 2 | VGNC:13827 | 458441 | |||||
Macaque | acyl-CoA synthetase short chain family member 2 | 706703 | ||||||
Mouse | MGI:1890410 | 60525 | ||||||
Rat | RGD:1305489 | 311569 | ||||||
Dog | acyl-CoA synthetase short chain family member 2 | VGNC:37537 | 477205 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | acyl-CoA synthetase short chain family member 2 | |||||
Macaque | acyl-CoA synthetase short chain family member 2 | |||||
Mouse | ||||||
Rat | ||||||
Dog | acyl-CoA synthetase short chain family member 2 | |||||
Publication Statistics
PubMed Score 220.75
PubMed score by year
PubTator Score 77.86
PubTator score by year
Related Publications
Text Mined References (30)
GeneRif Annotations (21)
Items per page:
0 of 0
PMID | Year | Title |
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