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Tbio
ACSS2
Acetyl-coenzyme A synthetase, cytoplasmic

Protein Summary
Description
Activates acetate so that it can be used for lipid synthesis or for energy generation. This gene encodes a cytosolic enzyme that catalyzes the activation of acetate for use in lipid synthesis and energy generation. The protein acts as a monomer and produces acetyl-CoA from acetate in a reaction that requires ATP. Expression of this gene is regulated by sterol regulatory element-binding proteins, transcription factors that activate genes required for the synthesis of cholesterol and unsaturated fatty acids. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000253382
  • ENSP00000253382
  • ENSG00000131069
  • ENST00000360596
  • ENSP00000353804

Symbol
  • ACAS2
  • ACS
  • ACSA
  • ACAS2
  • ACECS
  • dJ1161H23.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.94
molecular function
0.91
kinase perturbation
0.84
transcription factor binding site profile
0.77
small molecule perturbation
0.75


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
View Data
 GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 214.39   (req: < 5)
View Publications
Gene RIFs: 21   (req: <= 3)
View Gene RIFs
Antibodies: 381   (req: <= 50)
View Antibodies
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 214.39   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 381   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
View GO Terms
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
Items per page:
1 – 1 of 1
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
EFO_0004980
2
1
2
94.9
Items per page:
1 – 1 of 1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
EFO_0004980
2
94.9
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
acyl-CoA synthetase short chain family member 2
VGNC:13827
458441
Macaque
acyl-CoA synthetase short chain family member 2
706703
Mouse
acyl-CoA synthetase short-chain family member 2
MGI:1890410
60525
Rat
acyl-CoA synthetase short-chain family member 2
RGD:1305489
311569
Dog
acyl-CoA synthetase short chain family member 2
VGNC:37537
477205
Species
Name
OMA
EggNOG
Inparanoid
Chimp
acyl-CoA synthetase short chain family member 2
Macaque
acyl-CoA synthetase short chain family member 2
Mouse
acyl-CoA synthetase short-chain family member 2
Rat
acyl-CoA synthetase short-chain family member 2
Dog
acyl-CoA synthetase short chain family member 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9NR19-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (44)
Biological oxidations (R-HSA-211859)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Biological oxidations
221 targets
R-HSA-211859
Reactome
Ethanol oxidation
12 targets
R-HSA-71384
Reactome
Metabolism
2112 targets
R-HSA-1430728
Reactome
Mitochondrial biogenesis
89 targets
R-HSA-1592230
Reactome
Organelle biogenesis and maintenance
276 targets
R-HSA-1852241
Name
Explore in Pharos
Explore in Source
Biological oxidations
221 targets
R-HSA-211859
Ethanol oxidation
12 targets
R-HSA-71384
Metabolism
2112 targets
R-HSA-1430728
Mitochondrial biogenesis
89 targets
R-HSA-1592230
Organelle biogenesis and maintenance
276 targets
R-HSA-1852241
Gene Ontology Terms (13)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
acetate-CoA ligase activity
Inferred from Direct Assay (IDA)
UniProtKB
AMP binding
Inferred by Curator (IC)
UniProtKB
ATP binding
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (164)
1 – 10 of 164
ACACA
Tchem
Family: Enzyme
Novelty: 0.00248313
Score: 0.969
Data Source: STRINGDB
SIRT3
Tchem
Family: Epigenetic
Novelty: 0.00101187
Score: 0.963
Data Source: Reactome,STRINGDB
ACACB
Tchem
Family: Enzyme
Novelty: 0.00462116
Score: 0.959
Data Source: STRINGDB
SIRT1
Tchem
Family: Epigenetic
Novelty: 0.00022265
Score: 0.955
Data Source: STRINGDB
IDH2
Tclin
Family: Enzyme
Novelty: 0.00131782
Score: 0.948
Data Source: STRINGDB
ALDH2
Tclin
Family: Enzyme
Novelty: 0.00077122
Score: 0.941
Data Source: STRINGDB
ACAT1
Tchem
Family: Enzyme
Novelty: 0.00908928
Score: 0.939
Data Source: STRINGDB
ALDH3A2
Tbio
Family: Enzyme
Novelty: 0.0059198
Score: 0.939
Data Source: STRINGDB
ALDH3B1
Tbio
Family: Enzyme
Novelty: 0.03330389
Score: 0.938
Data Source: STRINGDB
ACOT12
Tbio
Family: Enzyme
Novelty: 0.04464523
Score: 0.938
Data Source: STRINGDB
Publication Statistics
PubMed Score  214.39

PubMed score by year
PubTator Score  77.86

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer