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Tchem
ACSS2
Acetyl-coenzyme A synthetase, cytoplasmic

Protein Summary
Description
Activates acetate so that it can be used for lipid synthesis or for energy generation. This gene encodes a cytosolic enzyme that catalyzes the activation of acetate for use in lipid synthesis and energy generation. The protein acts as a monomer and produces acetyl-CoA from acetate in a reaction that requires ATP. Expression of this gene is regulated by sterol regulatory element-binding proteins, transcription factors that activate genes required for the synthesis of cholesterol and unsaturated fatty acids. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000253382
  • ENSP00000253382
  • ENSG00000131069
  • ENST00000360596
  • ENSP00000353804

Symbol
  • ACAS2
  • ACS
  • ACSA
  • ACAS2
  • ACECS
  • dJ1161H23.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.94
molecular function
0.91
kinase perturbation
0.84
transcription factor binding site profile
0.77
small molecule perturbation
0.75


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 220.75   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 381   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 220.75   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 381   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 221
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (221)
CHEMBL4550594
Rendered image for CHEMBL4550594
CHEMBL4449652
Rendered image for CHEMBL4449652
CHEMBL4535842
Rendered image for CHEMBL4535842
CHEMBL4473187
Rendered image for CHEMBL4473187
CHEMBL4463979
Rendered image for CHEMBL4463979
CHEMBL4560160
Rendered image for CHEMBL4560160
CHEMBL4548954
Rendered image for CHEMBL4548954
CHEMBL4476365
Rendered image for CHEMBL4476365
CHEMBL4466204
Rendered image for CHEMBL4466204
CHEMBL4539904
Rendered image for CHEMBL4539904
Protein-Protein Interactions (164)
ACACA
Tchem
Family:  Enzyme
Novelty:  0.00248313
Score:  0.969
Data Source:  STRINGDB
SIRT3
Tchem
Family:  Epigenetic
Novelty:  0.00101187
Score:  0.963
Data Source:  Reactome,STRINGDB
ACACB
Tchem
Family:  Enzyme
Novelty:  0.00462116
Score:  0.959
Data Source:  STRINGDB
SIRT1
Tchem
Family:  Epigenetic
Novelty:  0.00022265
Score:  0.955
Data Source:  STRINGDB
IDH2
Tclin
Family:  Enzyme
Novelty:  0.00131782
Score:  0.948
Data Source:  STRINGDB
ALDH2
Tclin
Family:  Enzyme
Novelty:  0.00077122
Score:  0.941
Data Source:  STRINGDB
ACAT1
Tchem
Family:  Enzyme
Novelty:  0.00908928
Score:  0.939
Data Source:  STRINGDB
ALDH3A2
Tbio
Family:  Enzyme
Novelty:  0.0059198
Score:  0.939
Data Source:  STRINGDB
ALDH3B1
Tbio
Family:  Enzyme
Novelty:  0.03330389
Score:  0.938
Data Source:  STRINGDB
ACOT12
Tbio
Family:  Enzyme
Novelty:  0.04464523
Score:  0.938
Data Source:  STRINGDB
Pathways (44)
Biological oxidations (R-HSA-211859)

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Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Biological oxidations
Reactome
Ethanol oxidation
Reactome
Metabolism
Reactome
Mitochondrial biogenesis
Reactome
Organelle biogenesis and maintenance
Name
Explore in Pharos
Explore in Source
Biological oxidations
Ethanol oxidation
Metabolism
Mitochondrial biogenesis
Organelle biogenesis and maintenance
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (25)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
3
3
7
97.1
suntan
1
2
2
96
glomerular filtration rate
3
2
2
8.6
92.4
BMI-adjusted hip circumference
3
4
5
86.8
electrocardiography
1
1
41
75.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
7
97.1
suntan
2
96
glomerular filtration rate
2
8.6
92.4
BMI-adjusted hip circumference
5
86.8
electrocardiography
41
75.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
acyl-CoA synthetase short chain family member 2
VGNC:13827
458441
Macaque
acyl-CoA synthetase short chain family member 2
706703
Mouse
MGI:1890410
60525
Rat
RGD:1305489
311569
Dog
acyl-CoA synthetase short chain family member 2
VGNC:37537
477205
Species
Name
OMA
EggNOG
Inparanoid
Chimp
acyl-CoA synthetase short chain family member 2
Macaque
acyl-CoA synthetase short chain family member 2
Mouse
Rat
Dog
acyl-CoA synthetase short chain family member 2
Publication Statistics
PubMed Score 220.75
PubMed score by year
PubTator Score 77.86
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title