ACSS2
Acetyl-coenzyme A synthetase, cytoplasmic
Protein Summary
Activates acetate so that it can be used for lipid synthesis or for energy generation. This gene encodes a cytosolic enzyme that catalyzes the activation of acetate for use in lipid synthesis and energy generation. The protein acts as a monomer and produces acetyl-CoA from acetate in a reaction that requires ATP. Expression of this gene is regulated by sterol regulatory element-binding proteins, transcription factors that activate genes required for the synthesis of cholesterol and unsaturated fatty acids. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2009]
- ENST00000253382
- ENSP00000253382
- ENSG00000131069
- ENST00000360596
- ENSP00000353804
- ACAS2
- ACS
- ACSA
- ACAS2
- ACECS
- dJ1161H23.1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor perturbation | 0.94 | ||
molecular function | 0.91 | ||
kinase perturbation | 0.84 | ||
transcription factor binding site profile | 0.77 | ||
small molecule perturbation | 0.75 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 304.92 (req: < 5)
Gene RIFs: 30 (req: <= 3)
Antibodies: 381 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 304.92 (req: >= 5)
Gene RIFs: 30 (req: > 3)
Antibodies: 381 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 233
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0