Tdark ZNF302 Zinc finger protein 302

Protein Summary

Description

May be involved in transcriptional regulation. This gene encodes a member of the zinc-finger protein family. The encoded protein contains seven C2H2-type zinc fingers and a KRAB domain, but its function has yet to be determined. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2014]

Uniprot Accession IDs

• Q9NR11
• Q658J3
• Q9BZD8
• Q9P0J4

Gene Name

• ZNF302

Ensembl ID

• ENST00000423823
• ENSP00000405219
• ENSG00000089335
• ENST00000457781
• ENSP00000391067
• ENST00000505242
• ENSP00000421028

Symbol

• ZNF135L
• ZNF140L
• ZNF327
• HSD16
• MST154
• ZNF327
• MSTP154
• ZNF135L
• ZNF140L

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.73
PubMedID	0.65
cell line	0.59
protein domain	0.58
tissue sample	0.56

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.79   (req: < 5)

Gene RIFs: 0   (req: <= 3)

Antibodies: 107   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.79   (req: >= 5)

Gene RIFs: 0   (req: > 3)

Antibodies: 107   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Pathways (4)

Reactome (3)

KEGG (1)

Gene expression (Transcription) (R-HSA-74160)

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Items per page:

5

1 – 3 of 3

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Gene expression (Transcription)	1452 targets	R-HSA-74160
Reactome	Generic Transcription Pathway	1195 targets	R-HSA-212436
Reactome	RNA Polymerase II Transcription	1314 targets	R-HSA-73857

Name	Explore in Pharos	Explore in Source
Gene expression (Transcription)	1452 targets	R-HSA-74160
Generic Transcription Pathway	1195 targets	R-HSA-212436
RNA Polymerase II Transcription	1314 targets	R-HSA-73857

Gene Ontology Terms (4)

Functions (3)

Components (1)

Items per page:

10

1 – 3 of 3

GO Term	Evidence	Assigned by
DNA-binding transcription factor activity, RNA polymerase II-specific	Inferred from Sequence Alignment (ISA)	NTNU_SB
DNA binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
metal ion binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Protein-Protein Interactions (10)

Explore Interacting Targets

1 – 10 of 10

• See Interactions on String-DB

VWCE

Tbio

Novelty: 0.10129635

p_int: 0.999983725

p_ni: 2.5e-8

p_wrong: 0.00001625

Data Source: BioPlex

TMEM25

Tdark

Novelty: 0.57954545

p_int: 0.986158615

p_ni: 0.013718839

p_wrong: 0.000122546

Data Source: BioPlex

RFPL4B

Tdark

p_int: 0.945127691

p_ni: 4.1e-8

p_wrong: 0.054872268

Score: 0.201

Data Source: BioPlex,STRINGDB

DMC1

Tbio

Novelty: 0.07202881

p_int: 0.864281735

p_ni: 0.135717576

p_wrong: 6.89e-7

Score: 0.327

Data Source: BioPlex,STRINGDB

TRIM28

Tbio

Family: Epigenetic

Novelty: 0.01042773

Score: 0.903

Data Source: STRINGDB

ANKRA2

Tbio

Novelty: 0.29511652

Score: 0.542

Data Source: STRINGDB

ZFYVE16

Tbio

Novelty: 0.155836

Score: 0.53

Data Source: STRINGDB

SCGB2B2

Tdark

Novelty: 1

Score: 0.44

Data Source: STRINGDB

UBA2

Tbio

Novelty: 0.02816874

Score: 0.401

Data Source: STRINGDB

LSM14A

Tbio

Novelty: 0.07175157

Score: 0.4

Data Source: STRINGDB

Publication Statistics

PubMed Score  0.79

PubMed score by year

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PubTator Score  0.92

PubTator score by year

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Amino Acid Sequence

Residue Counts

Sequence

MSQVTFSDVAIDFSHEEWACLDSAQRDLYKDVMVQNYENLVSVGLSVTKPYVIMLLEDGKEPWMMEKKLS

1-70

KAYPFPLSHSVPASVNFGFSALFEHCSEVTEIFELSELCVFWVLHFLSNSPNSTVEAFSRSKKKKKKKKK

70-140

RQCFAFLIYFRLGIKMGKQGIINKEGYLYEDSPQPVTMEKVVKQSYEFSNSNKNLEYTECDTFRSTFHSK

140-210

STLSEPQNNSAEGNSHKYDILKKNLSKKSVIKSERINGGKKLLNSNKSGAAFNQSKSLTLPQTCNREKIY

210-280

TCSECGKAFGKQSILSRHWRIHTGEKPYECRECGKTFSHGSSLTRHQISHSGEKPYKCIECGKAFSHGSS

280-350

LTNHQSTHTGEKPYECMNCGKSFSRVSLLIQHLRIHTQEKRYECRICGKAFIHSSSLIHHQKSHTGEKPY

350-420

ECRECGKAFCCSSHLTQHQRIHSMKKKYECNKCLKVFSSFSFLVQHQSIHTEEKPFEV

420-478

MSQVTFSDVAIDFSHEEWACLDSAQRDLYKDVMVQNYENLVSVGLSVTKPYVIMLLEDGKEPWMMEKKLSKAYPFPLSHSVPASVNFGFSALFEHCSEVTEIFELSELCVFWVLHFLSNSPNSTVEAFSRSKKKKKKKKKRQCFAFLIYFRLGIKMGKQGIINKEGYLYEDSPQPVTMEKVVKQSYEFSNSNKNLEYTECDTFRSTFHSKSTLSEPQNNSAEGNSHKYDILKKNLSKKSVIKSERINGGKKLLNSNKSGAAFNQSKSLTLPQTCNREKIYTCSECGKAFGKQSILSRHWRIHTGEKPYECRECGKTFSHGSSLTRHQISHSGEKPYKCIECGKAFSHGSSLTNHQSTHTGEKPYECMNCGKSFSRVSLLIQHLRIHTQEKRYECRICGKAFIHSSSLIHHQKSHTGEKPYECRECGKAFCCSSHLTQHQRIHSMKKKYECNKCLKVFSSFSFLVQHQSIHTEEKPFEV

Find similar targets by:

Uniprot Keyword

Alternative splicing
Complete proteome
DNA-binding
Isopeptide bond
Metal-binding
Nucleus
Reference proteome
Repeat
Transcription
Transcription regulation